Results 31 to 40 of about 4,152,860 (338)

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection [PDF]

, 2017
Urinary tract infections: targeting enzymes might help Identifying bacterial and host enzymes that support biofilm formation may help prevent urinary tract infections caused by catheters.
Caparon, Michael G, Cusumano, Zachary T, Flores-Mireles, Ana L, Hultgren, Scott J, Takagi, Enzo, Xu, Wei   +5 more
core   +3 more sources

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Retrovirology, 2011
Background Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles.
Konvalinka Jan, Maas Renée EM, Schipper Pauline J, Pokorná Jana, van Maarseveen Noortje M, Fun Axel, Nijhuis Monique   +6 more
doaj   +1 more source

High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - A prospective cohort study.

PLoS ONE, 2020
BACKGROUND:Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on second-line protease inhibitor therapy is critical as ...
Rahel E Bircher, Alex J Ntamatungiro, Tracy R Glass, Dorcas Mnzava, Amina Nyuri, Herry Mapesi, Daniel H Paris, Manuel Battegay, Thomas Klimkait, Maja Weisser, KIULARCO study group   +10 more
doaj   +1 more source

Viral Protease Inhibitors [PDF]

, 2009
This review provides an overview of the development of viral protease inhibitors as antiviral drugs. We concentrate on HIV-1 protease inhibitors, as these have made the most significant advances in the recent past. Thus, we discuss the biochemistry of HIV-1 protease, inhibitor development, clinical use of inhibitors, and evolution of resistance.
Anderson, Jeffrey, Schiffer, Celia, Lee, Sook-Kyung, Swanstrom, Ronald   +3 more
openaire   +2 more sources

Peptide-based protease inhibitors from plants.

Drug Discovery Today, 2019
Proteases have an important role in homeostasis, and dysregulation of protease function can lead to pathogenesis. Therefore, proteases are promising drug targets in cancer, inflammation, and neurodegenerative disease research.
Roland Hellinger, Christian W. Gruber
semanticscholar   +1 more source

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

Molecules, 2019
HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this drug resistance and inhibit viral maturation, targeting Gag alongside protease rather than ...
Chinh Tran-To Su, Darius Wen-Shuo Koh, Samuel Ken-En Gan   +2 more
doaj   +1 more source

Virtual screening and molecular dynamics simulation study of plant protease inhibitors against SARS-CoV-2 envelope protein

Informatics in Medicine Unlocked, 2022
Due to the outbreak of a new strain of pandemic coronavirus, there is a huge loss of economy and health. In 2021, some vaccines are recommended as emergency licensed vaccines to protect against the virus, and efforts are continuously ongoing to evaluate ...
Manisha Kirar, Hitesh Singh, Neelam Sehrawat   +2 more
doaj   +1 more source

Plant Serine Protease Inhibitors: Biotechnology Application in Agriculture and Molecular Farming

International Journal of Molecular Sciences, 2019
The serine protease inhibitors (SPIs) are widely distributed in living organisms like bacteria, fungi, plants, and humans. The main function of SPIs as protease enzymes is to regulate the proteolytic activity.
Marina Clemente, Mariana G. Corigliano, Sebastián Pariani, Edwin F. Sánchez-López, V. Sander, Victor A. Ramos-Duarte   +5 more
semanticscholar   +1 more source

Sechs historische Grabsteine, um 1700, vom Alten Friedhof in Gießen [PDF]

, 1994
In this work, we applied a coarse-grained molecular dynamics method for simulating inhibitors entering the binding cavity of human immunodeficiency virus type 1 protease (HIV-1 PR).
Huang, Yonggang, Hwang, K. C., Ji, Baohua, Li, Dechang, Liu, Ming S.   +4 more
core   +1 more source

Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System

Viruses, 2015
Retroviral protease inhibitors (PIs) are fundamental pillars in the treatment of HIV infection and acquired immunodeficiency syndrome (AIDS). Currently used PIs are designed against HIV-1, and their effect on HIV-2 is understudied.
Mohamed Mahdi, Zsófia Szojka, János András Mótyán, József Tőzsér   +3 more
doaj   +1 more source