Results 31 to 40 of about 1,166,800 (296)

Inhibitory Effect of Protease Inhibitors on Larval Midgut Protease Activities and the Performance of Plutella xylostella (Lepidoptera: Plutellidae)

Frontiers in Physiology, 2019
Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao, Aiping Zhao, Yin Li, Yin Li, Chunmeng Leng, Chunmeng Leng, Ping Wang, Yiping Li, Yiping Li   +8 more
doaj   +1 more source

Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors

Viruses
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke, Moritz Petersen, Daniel Sauter   +2 more
doaj   +1 more source

The role of the HIV-1 protease substrate in therapy resistance [PDF]

, 2015
In Switzerland and Germany up to a half of the first-line regimens include protease inhibitors (PIs) [1, 2]. Although in the Swiss HIV Cohort Study (SHCS) most patients under antiretroviral therapy (ART) have suppressed viral loads [3], every third ...
Kletenkov, Konstantin
core   +1 more source

Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors

Viruses
Cervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo, Salerwe Mosebi, Zukile Mbita   +2 more
doaj   +1 more source

A modular system to evaluate the efficacy of protease inhibitors against HIV-2.

PLoS ONE, 2014
The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi, Krisztina Matúz, Ferenc Tóth, József Tőzsér   +3 more
doaj   +1 more source

Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection [PDF]

, 2004
The initial virus strains from as many as 12% of individuals with primary human immunodeficiency virus (HIV) infection have a 50% inhibitory concentration less than or equal to0.4-fold that of HIV type 1(NL4-3) (HIV-1(NL4-3)) to ritonavir ...
Joseph B. Margolick, Routy, JP, Susan J. Little, Frost, SDW, Leigh Brown, AJ, Connick, E, Little, SJ, Markowitz, M, Elizabeth Connick, Douglas D. Richman, Collier, AC, Richman, DD, Hellmann, NS, Brian Conway, Daar, ES, Good, B, Jacques Corbeil, Eric S. Daar, Margolick, JB, Simon D. W. Frost, Corbeil, J, Jean-Pierre Routy, Nicholas S. Hellmann, Benjamin Good, Viviana Simon, Simon, V, Ann C. Collier, Martin Markowitz, Conway, B, Andrew J. Leigh Brown   +29 more
core   +1 more source

Detecção de inibidores de proteases em sementes de Punica granatum

Química Nova
The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares, Antero Ricardo Santos Neto, Isac Henrique Cordeiro, Sandra Bertelli Ribeiro de Castro, Rodrigo Moreira Verly, Caio Cesar de Souza Alves, Alessandra de Paula Carli   +6 more
doaj   +1 more source

Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes.

PLoS ONE, 2016
First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck, Angela Horvath, Monika Tawdrous, Bianca Schmerböck, Gabriele Zettel, Andreas Posch, Andrea Streit, Petra Jurse, Sandra Lemesch, Martin Horn, Gerit Wuensch, Philipp Stiegler, Rudolf E Stauber, Bettina Leber, Vanessa Stadlbauer   +14 more
doaj   +1 more source

Synthesis and enzymatic inhibition effects of thiazolidinedione 3C-like protease inhibitors

Journal of Chemical Research, 2023
The 3C-like protease (also known as M pro ) plays a key role in SARS-CoV-2 replication and has similar substrates across mutant coronaviruses, making it an ideal drug target.
Xin Ye, Yuhua Li, Lina Guo, Yiling Yao, Rouyu Zhu, Shuang Wei, Hua Diao, Zhiyu Shao   +7 more
doaj   +1 more source

Inhibitor‐assisted refolding of protease: A protease inhibitor as an intramolecular chaperone [PDF]

FEBS Letters, 2005
Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and ...
Kojima, Shuichi, Iwahara, Akane, Yanai, Hideyuki   +2 more
openaire   +2 more sources