Results 31 to 40 of about 1,229,602 (196)
Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors
VirusesThe human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke +2 more
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Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors
VirusesCervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo +2 more
doaj +1 more source
PLoS ONE, 2016 First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck +14 more
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A modular system to evaluate the efficacy of protease inhibitors against HIV-2.
PLoS ONE, 2014 The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi +3 more
doaj +1 more source
Detecção de inibidores de proteases em sementes de Punica granatum
Química NovaThe use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares +6 more
doaj +1 more source
Synthesis and enzymatic inhibition effects of thiazolidinedione 3C-like protease inhibitors
Journal of Chemical Research, 2023 The 3C-like protease (also known as M pro ) plays a key role in SARS-CoV-2 replication and has similar substrates across mutant coronaviruses, making it an ideal drug target.
Xin Ye +7 more
doaj +1 more source
Inhibitor‐assisted refolding of protease: A protease inhibitor as an intramolecular chaperone [PDF]
FEBS Letters, 2005 Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and ...
Kojima, Shuichi +2 more
openaire +2 more sources
Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař +5 more
doaj +1 more source
Advancement in the Development of Therapeutics Against Zika Virus Infection
Frontiers in Cellular and Infection Microbiology, 2022 Zika virus (ZIKV), a re-emerging arbovirus, causes teratogenic effects on the fetus and normal nerve functions, resulting in harmful autoimmune responses, which call for the development of therapeutics against ZIKV infection. In this review, we introduce
Kangchen Li +3 more
doaj +1 more source
Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito +6 more
core +1 more source