Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors
VirusesCervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo +2 more
doaj +1 more source
PLoS ONE, 2016 First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck +14 more
doaj +1 more source
SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model
Science, 2021 Targeting the SARS-CoV-2 main protease Vaccines are an important tool in the fight against COVID-19, but developing antiviral drugs is also a high priority, especially with the rise of variants that may partially evade vaccines.
J. Qiao +42 more
semanticscholar +1 more source
Detecção de inibidores de proteases em sementes de Punica granatum
Química NovaThe use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares +6 more
doaj +1 more source
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
Science, 2020 Promising antiviral protease inhibitors With no vaccine or proven effective drug against the virus that causes coronavirus disease 2019 (COVID-19), scientists are racing to find clinical antiviral treatments.
Wenhao Dai +26 more
semanticscholar +1 more source
Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease. [PDF]
, 2018 Viruses are underrepresented as targets in pharmacological screening efforts, given the difficulties of devising suitable cell-based and biochemical assays.
Duggan, Brendan M +8 more
core +3 more sources
A modular system to evaluate the efficacy of protease inhibitors against HIV-2.
PLoS ONE, 2014 The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi +3 more
doaj +1 more source
Synthesis and enzymatic inhibition effects of thiazolidinedione 3C-like protease inhibitors
Journal of Chemical Research, 2023 The 3C-like protease (also known as M pro ) plays a key role in SARS-CoV-2 replication and has similar substrates across mutant coronaviruses, making it an ideal drug target.
Xin Ye +7 more
doaj +1 more source
Metabolic and cardiac adaptation to chronic pharmacologic blockade of facilitative glucose transport in murine dilated cardiomyopathy and myocardial ischemia [PDF]
, 2018 GLUT transgenic and knockout mice have provided valuable insight into the role of facilitative glucose transporters (GLUTs) in cardiovascular and metabolic disease, but compensatory physiological changes can hinder interpretation of these models.
Heitmeier, Monique R. +6 more
core +2 more sources
Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design
Biomedicines, 2021 Zika virus (ZIKV)—a member of the Flaviviridae family—is an important human pathogen. Its genome encodes a polyprotein that can be further processed into structural and non-structural proteins.
Qingxin Li, Congbao Kang
doaj +1 more source