Results 61 to 70 of about 1,229,602 (196)

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

Universitas Scientiarum, 2019
The HIV-1 protease plays an essential role in the replication cycle of HIV-1; therefore there is a direct need to develop novel inhibitors of the HIV-1 protease, which can cease the viral replication.
Ammara Akhtar, Waqar Hussain, Nouman Rasool3
doaj   +1 more source

Molecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus [PDF]

, 2008
Background The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutations that confer varying degrees of
Stefan Zeuzem, Albrecht, M., Hartmann, Christoph, Mayr, G., Andreas Schlicker, Welsch, C., Sarrazin, C., Susser, Simone, Sarrazin, Christoph, Lengauer, T., Albrecht, Mario, Christoph Welsch, Thomas Lengauer, Christoph Sarrazin, Antes, I., Mayr, Gabriele, Iris Antes, Simone Susser, Gabriele Mayr, Lengauer, Thomas, Susser, S., Zeuzem, S., Hartmann, C., Christoph Hartmann, Mario Albrecht, Schlicker, A., Francisco S Domingues, Domingues, Francisco S., Domingues, F., Welsch, Christoph, Schlicker, Andreas, Antes, Iris, Zeuzem, Stefan, Welsch, C.;Domingues, F. S.;Susser, S.;Antes, I.;Hartmann, C.;Mayr, G.;Schlicker, A.;Sarrazin, C.;Albrecht, M.;Zeuzem, S.;Lengauer, T.   +33 more
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List of protease inhibitors with transcriptomics and protein expression.

, 2022
List of protease inhibitors with transcriptomics and protein expression.
Antonia Vlahou (114470), Joachim Jankowski (114466), Justyna Siwy (103595), Eleni Petra (129612)   +3 more
core   +1 more source

The effects of protease inhibitors on basal and insulin-stimulated lipid metabolism, insulin binding, and signaling

Journal of Lipid Research, 2003
The objective of our research was to investigate the effects of the protease inhibitors ritonavir, saquinavir, and indinavir on triglyceride synthesis, lipolysis, insulin binding, and signaling in differentiating 3T3 L1 pre-adipocytes.
Catarina Cammalleri, Ralph J. Germinario
doaj   +1 more source

Classification of protease inhibitors used.

, 2013
Classification of protease inhibitors used.
Sachiko Takehara (434911), Katarzyna Anna Podyma-Inoue (434912), Masaki Yanagishita (180077), Yoko Kawaguchi (434913)   +3 more
core   +1 more source

Cystatin activity–based protease profiling to select protease inhibitors useful in plant protection

, 2020
Protease inhibitors of the cystatin protein superfamily show potential in plant protection for the control of herbivorous pests. Here, we describe a cystatin activity–based profiling procedure for the selection of potent cystatin candidates, using single
Sainsbury, Frank, Michaud, Dominique, Marie-Claire Goulet, Frank Sainsbury, Michaud, D, Goulet, Marie-Claire, Dominique Michaud, Goulet, MC, Sainsbury, F   +8 more
core   +1 more source

Developing HIV-1 Protease Inhibitors through Stereospecific Reactions in Protein Crystals

Molecules, 2016
Protease inhibitors are key components in the chemotherapy of HIV infection. However, the appearance of viral mutants routinely compromises their clinical efficacy, creating a constant need for new and more potent inhibitors.
Folasade M. Olajuyigbe, Nicola Demitri, Rita De Zorzi, Silvano Geremia   +3 more
doaj   +1 more source

Structural basis for the regulation of cysteine-protease activity by a new class of protease inhibitors in Plasmodium

, 2011
Plasmodium cysteine proteases are essential for host-cell invasion and egress, hemoglobin degradation, and intracellular development of the parasite. The temporal, site-specific regulation of cysteine-protease activity is a prerequisite for survival and ...
Volker T. Heussler, Anna Heitmann, Honglin Li, Heitmann, A., Witt, T., Heussler, V.T., Jiang, H., Tina Witt, Heussler, Volker, Rolf Hilgenfeld, Shen, X., Hilgenfeld, R., Xu Shen, Annika Rennenberg, Guido Hansen, Hualiang Jiang, Li, H., Hansen, G., Rennenberg, A.   +18 more
core   +1 more source

The L76V mutation in HIV-1 protease is potentially associated with hypersusceptibility to protease inhibitors Atazanavir and Saquinavir: is there a clinical advantage? [PDF]

, 2011
Background: Although being considered as a rarely observed HIV-1 protease mutation in clinical isolates, the L76V-prevalence increased 1998-2008 in some European countries most likely due to the approval of Lopinavir, Amprenavir and Darunavir which can ...
Braun, Patrick, Ehret Robert, Naeth, Gudrun, Frank Wiesmann, Tappe André, Tappe, André, Rolf Kaiser, Martin Stürmer, Hauke Walter, Jan Vachta, Walter, Hauke, André Tappe, Ehret, Robert, Stürmer Martin, Thomas Berg, Kaiser Rolf, Robert Ehret, Berg Thomas, Naeth Gudrun, Knechten Heribert, Gudrun Naeth, Patrick Braun, Knechten, Heribert, Stürmer, Martin, Wiesmann, Frank, Vachta, Jan, Heribert Knechten, Kaiser, Rolf, Berg, Thomas, Walter Hauke, Martin Däumer, Braun Patrick, Däumer Martin, Wiesmann Frank, Vachta Jan, Däumer, Martin   +35 more
core   +1 more source

Peptide inhibitors of hepatitis C virus NS3 protease

, 2003
Hepatitis C virus (HCV) is a highly prevalent virus and one of the major agents of chronic hepatitis. Since HCV NS3 protease is essential for the processing of HCV polyprotein, this protease is a target of choice to control HCV replication.
García-Delgado, M. (Marina), Vizmanos-Pérez, J.L. (José Luis), Lasarte, J.J. (Juan José), Borras-Cuesta, F. (Francisco), Gonzalez-Navarro, C.J. (Carlos Javier), Portal, S. (Sergio)   +5 more
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