Results 81 to 90 of about 1,229,602 (196)

Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening

Nature Communications
Variants of SARS-CoV-2 have continued to emerge across the world and cause hundreds of deaths each week. Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics with pan ...
Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell   +14 more
doaj   +1 more source

Rational design of serine protease inhibitors [PDF]

, 2011
Proteases regulate a spectrum of diverse physiological processes, and dysregulation of proteolytic activity drives a plethora of pathological conditions.
Swedberg, Joakim Erik
core  

Effect of protease inhibitors on VpSP37.

, 2015
Effect of protease inhibitors on VpSP37.
Monica Salamone (768136), Aldo Nicosia (633613), Angela Cuttitta (633616), Paola Quatrini (768138), Salvatore Mazzola (426101), Carmelo Bennici (768137), Valentina Catania (768139), Giulio Ghersi (768140)   +7 more
core   +1 more source

Protease inhibitors

, 2016
Protease inhibitors prevent maturation of viral proteins inside HIV particlesComponente Curricular::Educação Superior::Ciências da ...
Howard Hughes Medical Institute (HHMI)
core   +1 more source

Tick cysteine protease inhibitors suppress immune responses in mannan-induced psoriasis-like inflammation

Frontiers in Immunology
Protease inhibitors regulate various biological processes and prevent host tissue/organ damage. Specific inhibition/regulation of proteases is clinically valuable for treating several diseases.
Huimei Wu, Huimei Wu, Mohamed Amine Jmel, Jinwei Chai, Maolin Tian, Xueqing Xu, Xueqing Xu, Yuan Hui, Kutty Selva Nandakumar, Kutty Selva Nandakumar, Michail Kotsyfakis, Michail Kotsyfakis   +11 more
doaj   +1 more source

Diffusion of protease inhibitors in the muscle cell

, 2003
Proteases often exist in fish muscle, arising from parasites, gut leaching, or merely normal physiology. Their activity may cause undesired softening of the meat during storage or slow cooking.
Carvajal-Rondanelli, Patricio Armando
core  

Protease inhibitors. 2. Bacterial proteases and their inhibitors [PDF]

Biochemical Journal, 1949
E S, Duthie, L, Lorenz
openaire   +2 more sources

Pathophysiological significance and therapeutic applications of snake venom protease inhibitors

, 2017
Protease inhibitors are important constituents of snake venom and play important roles in the pathophysiology of snakebite. Recently, research on snake venom protease inhibitors has provided valuable information to decipher the molecular details of ...
Mukherjee, Ashis K., Rupamoni Thakur, Thakur, Rupamoni, Ashis K. Mukherjee   +3 more
core   +1 more source

Residual protease activities of recombinant pernisine in the presence of the protease inhibitors.

, 2015
ND, no data.Residual protease activities of recombinant pernisine in the presence of the protease inhibitors.
Dušan Turk (719808), Marko Šnajder (155035), Marko Mihelič (719807), Nataša Poklar Ulrih (155068)   +3 more
core   +1 more source

Optimized pipeline and designer cells for synthetic-biology-based high-throughput screening of viral protease inhibitors

Cell Reports: Methods
Summary: A reliable, efficient, high-throughput pipeline to evaluate viral protease inhibitors would enhance antiviral drug discovery. Methods such as crystallography and phenotypic screening are often constrained by complex assay conditions, limited ...
Shlomi Edri, Shayma El-Atawneh, Tehila Ernst, Maayan Elnekave, Chaja Katzman, Tali Lanton, Ido Aldar, Omri Wolk, Noa Stern, Amiram Goldblum, Lior Nissim   +10 more
doaj   +1 more source