Results 81 to 90 of about 1,166,800 (296)

HIV protease inhibitors differentially inhibit adhesion of Candida albicans to acrylic surfaces

, 2010
Highly active antiretroviral therapy (HAART), using HIV protease inhibitors, is commonly used in the management of HIV infection. HIV protease inhibitors also have a direct effect on a key virulence factor of Candida albicans, its secreted aspartyl ...
Tsang, CSP, Hong, I
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Inhibitors of Helicobacter pylori protease HtrA found by "virtual ligand" screening combat bacterial invasion of epithelia [PDF]

, 2011
Background: The human pathogen Helicobacter pylori (H. pylori) is a main cause for gastric inflammation and cancer. Increasing bacterial resistance against antibiotics demands for innovative strategies for therapeutic intervention.
Löwer, Martin, Schneider, Gisbert, Petra Schneider, Hoy Benjamin, Löwer Martin, Martin Löwer, Tim Geppert, Geppert, Tim, Silja Wessler, Wessler Silja, Schneider, Petra, Geppert Tim, Gisbert Schneider, Benjamin Hoy, Hoy, Benjamin, Weßler, Silja, Schneider Petra, Schneider, Gisbert (Prof. Dr.), Schneider Gisbert   +18 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Early structural and functional changes of the vasculature in HIV-infected children: Impact of disease and antiretroviral therapy [PDF]

, 2005
Background - Premature cardiovascular disease is increasingly recognized in HIV-infected patients, but the mechanisms involved are unclear. The purpose of this study was to determine the impact of HIV infection and antiretroviral therapy (ART) on markers
Clapson, Margaret, Halcox, Julian P., Donald, Ann E., Green, H, Halcox, JP, Deanfield, John E., Muriel Caslake, Charakida, M, Klein, Nigel J., Clapson, M, Caslake, M, Gibb, Diana M., Dunn, DT, Storry, C, Margaret Clapson, David T. Dunn, Clare Storry, Donald, AE, In Hiv-infected Children, Storry, Clare, Hannah Green, Green, Hannah, Diana M. Gibb, Nigel J. Klein, Gibb, DM, Klein, NJ, Deanfield, JE, Charakida, Marietta, Julian P. Halcox, Marietta Charakida, Caslake, Muriel, Ann E. Donald, Dunn, David T., John E. Deanfield   +33 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Probing the Pharmacological Binding Properties, and Reactivity of Selective Phytochemicals as Potential HIV-1 protease Inhibitors

Universitas Scientiarum, 2019
The HIV-1 protease plays an essential role in the replication cycle of HIV-1; therefore there is a direct need to develop novel inhibitors of the HIV-1 protease, which can cease the viral replication.
Ammara Akhtar, Waqar Hussain, Nouman Rasool3
doaj   +1 more source

Bioassays to monitor taspase1 function for the identification of pharmacogenetic inhibitors [PDF]

, 2011
Background: Threonine Aspartase 1 (Taspase1) mediates cleavage of the mixed lineage leukemia (MLL) protein and leukemia provoking MLL-fusions. In contrast to other proteases, the understanding of Taspase1's (patho)biological relevance and function is ...
Verena Fetz, Rabenstein Jens, Friedl Sandra, Eckhard Thines, Samaneh Sabiani, Kindler Thomas, Rabenstein, Jens, Bier, Carolin, Shirley K Knauer, Thomas Kindler, Kunst Lena, Stauber, Roland, Friedl, Sandra, Schneider, Gisbert, Knauer, Shirley K., Kunst, Lena, Carolin Bier, Knauer Shirley K., Fetz, Verena, Sabiani, Samaneh, Schröder Elisabeth, Proschak Eugen, Eugen Proschak, Roland H Stauber, Sandra Friedl, Thines, Eckhard, Gisbert Schneider, Lena Kunst, Sabiani Samaneh, Thines Eckhard, Roland H. Stauber, Marschalek Rolf, Proschak, Ewgenij, Schröder, Elisabeth, Bier Carolin, Kindler, Thomas, Proschak, Eugen, Stauber, Roland H., Hofmann Bettina, Elisabeth Schröder, Marschalek, Rolf (Prof. Dr.), Fetz Verena, Rolf Marschalek, Knauer, Shirley, Bettina Hofmann, Jens Rabenstein, Marschalek, Rolf, Hofmann, Bettina, Stauber Roland H., Schneider, Gisbert (Prof. Dr.), Schneider Gisbert, Shirley K. Knauer   +51 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cysteine proteinase inhibitors: purification and gene isolation [PDF]

, 1989
Genetic engineering has produced a transgenic insect- resistant plant which produces a serine protease inhibitor (Hilder et al., 1987). More insects can be targetted if a plant can be made to produce thiol protease inhibitors.
Fones, Angela Mei Ling
core