Results 21 to 30 of about 440,726 (262)

Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei

Ceylon Journal of Science, 2019
Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
doaj   +1 more source

Norovirus Protease Structure and Antivirals Development

Viruses, 2021
Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available.
Boyang Zhao, Liya Hu, Yongcheng Song, Ketki Patil, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, B. V. Venkataram Prasad   +7 more
doaj   +1 more source

Inhibitory Effect of Protease Inhibitors on Larval Midgut Protease Activities and the Performance of Plutella xylostella (Lepidoptera: Plutellidae)

Frontiers in Physiology, 2019
Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao, Aiping Zhao, Yin Li, Yin Li, Chunmeng Leng, Chunmeng Leng, Ping Wang, Yiping Li, Yiping Li   +8 more
doaj   +1 more source

Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors

Viruses
The human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke, Moritz Petersen, Daniel Sauter   +2 more
doaj   +1 more source

Detecção de inibidores de proteases em sementes de Punica granatum

Química Nova
The use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares, Antero Ricardo Santos Neto, Isac Henrique Cordeiro, Sandra Bertelli Ribeiro de Castro, Rodrigo Moreira Verly, Caio Cesar de Souza Alves, Alessandra de Paula Carli   +6 more
doaj   +1 more source

Triple Therapy with First Generation Protease Inhibitors for Hepatitis C Markedly Impairs Function of Neutrophil Granulocytes.

PLoS ONE, 2016
First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck, Angela Horvath, Monika Tawdrous, Bianca Schmerböck, Gabriele Zettel, Andreas Posch, Andrea Streit, Petra Jurse, Sandra Lemesch, Martin Horn, Gerit Wuensch, Philipp Stiegler, Rudolf E Stauber, Bettina Leber, Vanessa Stadlbauer   +14 more
doaj   +1 more source

Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors

Viruses
Cervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo, Salerwe Mosebi, Zukile Mbita   +2 more
doaj   +1 more source

A modular system to evaluate the efficacy of protease inhibitors against HIV-2.

PLoS ONE, 2014
The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi, Krisztina Matúz, Ferenc Tóth, József Tőzsér   +3 more
doaj   +1 more source

Protease Inhibitors in Tick Saliva: The Role of Serpins and Cystatins in Tick-host-Pathogen Interaction

Frontiers in Cellular and Infection Microbiology, 2017
The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař, Jan Kotál, Jan Kotál, Helena Langhansová, Helena Langhansová, Michail Kotsyfakis   +5 more
doaj   +1 more source

Synthesis and enzymatic inhibition effects of thiazolidinedione 3C-like protease inhibitors

Journal of Chemical Research, 2023
The 3C-like protease (also known as M pro ) plays a key role in SARS-CoV-2 replication and has similar substrates across mutant coronaviruses, making it an ideal drug target.
Xin Ye, Yuhua Li, Lina Guo, Yiling Yao, Rouyu Zhu, Shuang Wei, Hua Diao, Zhiyu Shao   +7 more
doaj   +1 more source