Results 21 to 30 of about 4,152,860 (338)

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

Science Advances, 2020
X-ray crystal structures of SARS-CoV-2 Mpro with dual inhibitors provide a new direction for the designing of COVID-19 antivirals. The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro inhibitors have a γ-lactam glutamine
M. Sacco, Chunlong Ma, Panagiotis Lagarias, A. Gao, J. A. Townsend, Xiangzhi Meng, P. Dube, Xiujun Zhang, Yanmei Hu, Naoya Kitamura, B. Hurst, Bart Tarbet, M. Marty, A. Kolocouris, Y. Xiang, Yu Chen, Jun Wang   +16 more
semanticscholar   +1 more source

Rapid enzymatic test for phenotypic HIV protease drug resistance [PDF]

, 2003
A phenotypic resistance test based on recombinant expression of the active HIV protease in E. coli from patient blood samples was developed. The protease is purified in a rapid onestep procedure as active enzyme and tested for inhibition by five selected
Assfalg-Machleidt, Irmgard, Helm, K. von der, Hoffmann, D., Koszinowski, U., Machleidt, Werner, Nitschko, H.   +5 more
core   +1 more source

SjAPI, the first functionally characterized Ascaris-type protease inhibitor from animal venoms. [PDF]

PLoS ONE, 2013
Serine protease inhibitors act as modulators of serine proteases, playing important roles in protecting animal toxin peptides from degradation. However, all known serine protease inhibitors discovered thus far from animal venom belong to the Kunitz-type ...
Zongyun Chen, Bin Wang, Jun Hu, Weishan Yang, Zhijian Cao, Renxi Zhuo, Wenxin Li, Yingliang Wu   +7 more
doaj   +1 more source

Interspecific differences between D. pulex and D. magna in tolerance to cyanobacteria with protease inhibitors. [PDF]

PLoS ONE, 2013
It is known that cyanobacteria negatively affect herbivores due to their production of toxins such as protease inhibitors. In the present study we investigated potential interspecific differences between two major herbivores, Daphnia magna and Daphnia ...
Christian J Kuster, Eric Von Elert
doaj   +1 more source

The association between protease inhibitors and anal cancer outcomes in veterans living with HIV treated with definitive chemoradiation: a retrospective study

BMC Cancer, 2021
Background The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the management of HIV, may increase ...
Alison K. Yoder, David S. Lakomy, Yongquan Dong, Suchismita Raychaudhury, Kathryn Royse, Christine Hartman, Peter Richardson, Donna L. White, Jennifer R. Kramer, Lilie L. Lin, Elizabeth Chiao   +10 more
doaj   +1 more source

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Carrillo Gil, Laura, Diaz Rodriguez, Isabel, Herrero, Ignacio, Martinez Muñoz, Manuel, Sánchez-Monge Laguna de Rins, Rosa   +5 more
core   +2 more sources

Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma

Plants, 2021
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple protease-mediated processes. Thus, effort has been invested in the development of protease inhibitors to prevent metastasis.
Sonia Yoo Im, Camila Ramalho Bonturi, Adriana Miti Nakahata, Clóvis Ryuichi Nakaie, Arnildo Pott, Vali Joana Pott, Maria Luiza Vilela Oliva   +6 more
doaj   +1 more source

Structural similarities between SARS-CoV2 3CLpro and other viral proteases suggest potential lead molecules for developing broad spectrum antivirals

Frontiers in Chemistry, 2022
Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein from
Khushboo Bafna, Khushboo Bafna, Christopher L. Cioffi, Robert M. Krug, Gaetano T. Montelione, Gaetano T. Montelione   +5 more
doaj   +1 more source

The protease inhibitors

Primary Care Update for OB/GYNS, 2001
With the advent of newer antiretroviral agents for the treatment of patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), health care providers are faced with many options to optimize their patients' therapy.
College of Medicine, University of Florida, Gainesville, Florida, USA ( host institution ), Tapp Alter, Karen   +1 more
openaire   +3 more sources

Progress in Developing Inhibitors of SARS-CoV-2 3C-Like Protease

Microorganisms, 2020
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The viral outbreak started in late 2019 and rapidly became a serious health threat to the global population.
Qingxin Li, C. Kang
semanticscholar   +1 more source