Results 21 to 30 of about 442,447 (259)
Frontiers in Physiology, 2019 Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao +8 more
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Restriction of Viral Glycoprotein Maturation by Cellular Protease Inhibitors
VirusesThe human genome is estimated to encode more than 500 proteases performing a wide range of important physiological functions. They digest proteins in our food, determine the activity of hormones, induce cell death and regulate blood clotting, for example.
Rishikesh Lotke +2 more
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Susceptibility of HPV-18 Cancer Cells to HIV Protease Inhibitors
VirusesCervical cancer cases continue to rise despite all the advanced screening and preventative measures put in place, which include human papillomavirus (HPV) vaccination.
Lilian Makgoo +2 more
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A modular system to evaluate the efficacy of protease inhibitors against HIV-2.
PLoS ONE, 2014 The human immunodeficiency virus (HIV) protease is a homodimeric aspartyl protease that is crucial for the viral life-cycle, cleaving proviral polyproteins, hence creating mature protein components that are required for the formation of an infectious ...
Mohamed Mahdi +3 more
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Detecção de inibidores de proteases em sementes de Punica granatum
Química NovaThe use of plants as a way to prevent and treat disease comes from ancient times. With the increasing return on consumption of plants for medicinal purposes, the plant-based medicines have gained greater appreciation.
Lara Franca Colares +6 more
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PLoS ONE, 2016 First-generation HCV protease inhibitors represent a milestone in antiviral therapy for chronic hepatitis C infection (CHC), but substantially increased rates of viral clearance are offset by increased rates of infection and infection-associated deaths ...
Walter Spindelboeck +14 more
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Synthesis and enzymatic inhibition effects of thiazolidinedione 3C-like protease inhibitors
Journal of Chemical Research, 2023 The 3C-like protease (also known as M pro ) plays a key role in SARS-CoV-2 replication and has similar substrates across mutant coronaviruses, making it an ideal drug target.
Xin Ye +7 more
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Inhibitor‐assisted refolding of protease: A protease inhibitor as an intramolecular chaperone [PDF]
FEBS Letters, 2005 Pleurotus ostrearus proteinase A inhibitor 1 (POIA1), which was discovered as a protease inhibitor, is unique in that it shows sequence homology to the propeptide of subtilisin, which functions as an intramolecular of a cognate protease. In this study, we demonstrate that POIA1 can function as an intramolecular chaperone of subtilisin by in vitro and ...
Kojima, Shuichi +2 more
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Frontiers in Cellular and Infection Microbiology, 2017 The publication of the first tick sialome (salivary gland transcriptome) heralded a new era of research of tick protease inhibitors, which represent important constituents of the proteins secreted via tick saliva into the host.
Jindřich Chmelař +5 more
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Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design
Biomedicines, 2021 Zika virus (ZIKV)—a member of the Flaviviridae family—is an important human pathogen. Its genome encodes a polyprotein that can be further processed into structural and non-structural proteins.
Qingxin Li, Congbao Kang
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