Results 21 to 30 of about 1,229,602 (196)

Phenotypic hypersusceptibility to multiple protease inhibitors and low replicative capacity in patients who are chronically infected with human immunodeficiency virus type 1 [PDF]

, 2005
Increased susceptibility to the protease inhibitors saquinavir and amprenavir has been observed in human immunodeficiency virus type 1 (HIV-1) with specific mutations in protease (V82T and N88S).
Wrin, T, Ruiz, L, Petropoulos, CJ, Clotet, B, Frost, SDW, Martinez-Picado, J, Leigh Brown, AJ, Parkin, NT   +7 more
core   +1 more source

Reviewing HIV-1 Gag Mutations in Protease Inhibitors Resistance: Insights for Possible Novel Gag Inhibitor Designs

Molecules, 2019
HIV protease inhibitors against the viral protease are often hampered by drug resistance mutations in protease and in the viral substrate Gag. To overcome this drug resistance and inhibit viral maturation, targeting Gag alongside protease rather than ...
Chinh Tran-To Su, Darius Wen-Shuo Koh, Samuel Ken-En Gan   +2 more
doaj   +1 more source

Virtual screening and molecular dynamics simulation study of plant protease inhibitors against SARS-CoV-2 envelope protein

Informatics in Medicine Unlocked, 2022
Due to the outbreak of a new strain of pandemic coronavirus, there is a huge loss of economy and health. In 2021, some vaccines are recommended as emergency licensed vaccines to protect against the virus, and efforts are continuously ongoing to evaluate ...
Manisha Kirar, Hitesh Singh, Neelam Sehrawat   +2 more
doaj   +1 more source

The protease inhibitors

Primary Care Update for OB/GYNS, 2001
With the advent of newer antiretroviral agents for the treatment of patients with human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS), health care providers are faced with many options to optimize their patients' therapy.
College of Medicine, University of Florida, Gainesville, Florida, USA ( host institution ), Tapp Alter, Karen   +1 more
openaire   +3 more sources

Differential in vitro and in vivo effect of barley cysteine and serine protease inhibitors on phytopathogenic microorganisms [PDF]

, 2011
Protease inhibitors from plants have been involved in defence mechanisms against pests and pathogens. Phytocystatins and trypsin/α-amylase inhibitors are two of the best characterized protease inhibitor families in plants.
Cambra Marin, Ines, Sánchez-Monge Laguna de Rins, Rosa, Diaz Rodriguez, Isabel, Herrero, Ignacio, Carrillo Gil, Laura, Martinez Muñoz, Manuel   +5 more
core   +1 more source

Inhibition Profiling of Retroviral Protease Inhibitors Using an HIV-2 Modular System

Viruses, 2015
Retroviral protease inhibitors (PIs) are fundamental pillars in the treatment of HIV infection and acquired immunodeficiency syndrome (AIDS). Currently used PIs are designed against HIV-1, and their effect on HIV-2 is understudied.
Mohamed Mahdi, Zsófia Szojka, János András Mótyán, József Tőzsér   +3 more
doaj   +1 more source

Class of antiretroviral drugs and the risk of myocardial infarction [PDF]

, 2007
BACKGROUND:We have previously demonstrated an association between combination antiretroviral therapy and the risk of myocardial infarction. It is not clear whether this association differs according to the class of antiretroviral drugs.
El-Sadr, W, De Wit, S, Phillips, Andrew, Friis-Moller, Nina, Weber, R, Reiss, Peter, Lundgren, JD, O. Kirk, W. M. El Sadr, Monforte, AD, R. Thiébaut, El-Sadr, Wafaa, R. Weber, Friis-Moller, N, N. Friis Møller, Law, MG, Lundgren, Jens D., Kirk, O, Thiebaut, Rodolphe, Fontas, E, Friis-Møller, Nina, De Wit, Stephane, Sabin, Caroline, P. Reiss, S. De Wit, A. N. Phillips, Sabin, CA, d'Arminio Monforte, Antonella, Law, Matthew G., Reiss, P, E. Fontas, Sabin, Caroline A., Lundgren, Jens D, DAD Study Grp, Monforte, Antonella d'Arminio, Phillips, Andrew N., J. D. Lundgren, Phillips, A, Fontas, Eric, M. G. Law, Weber, Rainer, C. A. Sabin, Kirk, Ole, A. d’Arminio Monforte, Law, Matthew, Lundgren, Jens Dilling, Fontas, E., Weber, R., Thiebault, R, Phillips, A., Monforte, A.D., Sabin, C.A., Wit, S. De, Law, M.G., Sadr, W. El, Reiss, P., D'Arminio Monforte, A   +56 more
core   +1 more source

Preliminary investigations on the serine and aspartic protease inhibitors from Nothopegia beddomei

Ceylon Journal of Science, 2019
Aqueous stem bark extract of Nothopegia beddomei was assayed for serine and aspartic protease inhibitors by using trypsin and pepsin as the target enzymes, respectively. Crude bark extract was dialyzed and subjected to inhibition assays.
M.G.K.P. Dayarathne, Sanath Rajapakse
doaj   +1 more source

Norovirus Protease Structure and Antivirals Development

Viruses, 2021
Human norovirus (HuNoV) infection is a global health and economic burden. Currently, there are no licensed HuNoV vaccines or antiviral drugs available.
Boyang Zhao, Liya Hu, Yongcheng Song, Ketki Patil, Sasirekha Ramani, Robert L. Atmar, Mary K. Estes, B. V. Venkataram Prasad   +7 more
doaj   +1 more source

Inhibitory Effect of Protease Inhibitors on Larval Midgut Protease Activities and the Performance of Plutella xylostella (Lepidoptera: Plutellidae)

Frontiers in Physiology, 2019
Plutella xylostella L. (diamondback moth) is a pest of cruciferous plants. To understand the relationship among protease inhibitors, protease activities and the growth and development of this insect, the activities of midgut proteases of P.
Aiping Zhao, Aiping Zhao, Yin Li, Yin Li, Chunmeng Leng, Chunmeng Leng, Ping Wang, Yiping Li, Yiping Li   +8 more
doaj   +1 more source