Results 11 to 20 of about 4,152,860 (338)

Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay

Communications Biology, 2022
SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug development. In this study, we present an antiviral screening strategy involving a novel in-cell protease assay, antiviral and biochemical activity assessments, as well as ...
Anoop Narayanan, M. Narwal, Sydney A. Majowicz, C. Varricchio, Shay A Toner, C. Ballatore, A. Brancale, K. Murakami, J. Jose   +8 more
semanticscholar   +1 more source

Comparative study of the unbinding process of some HTLV-1 protease inhibitors using unbiased molecular dynamics simulations.

PLoS ONE, 2022
The HTLV-1 protease is one of the major antiviral targets to overwhelm this virus. Several research groups have developed protease inhibitors, but none has been successful.
Fereshteh Noroozi Tiyoula, Hassan Aryapour, Mostafa Javaheri Moghadam   +2 more
doaj   +1 more source

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

Science, 2020
Targeting a key enzyme in SARS-CoV-2 Scientists across the world are working to understand severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19). Zhang et al.
Linlin Zhang, Daizong Lin, Xinyuanyuan Sun, U. Curth, C. Drosten, Lucie Sauerhering, S. Becker, K. Rox, R. Hilgenfeld   +8 more
semanticscholar   +1 more source

HIV Protease: Historical Perspective and Current Research

Viruses, 2021
The retroviral protease of human immunodeficiency virus (HIV) is an excellent target for antiviral inhibitors for treating HIV/AIDS. Despite the efficacy of therapy, current efforts to control the disease are undermined by the growing threat posed by ...
Irene T. Weber, Yuan-Fang Wang, Robert W. Harrison   +2 more
doaj   +1 more source

Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors

ACS Pharmacology & Translational Science, 2020
Among the drug targets being investigated for SARS-CoV-2, the viral main protease (Mpro) is one of the most extensively studied. Mpro is a cysteine protease that hydrolyzes the viral polyprotein at more than 11 sites.
Chunlong Ma, Yanmei Hu, J. A. Townsend, Panagiotis Lagarias, M. Marty, A. Kolocouris, Jun Wang   +6 more
semanticscholar   +1 more source

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Cell Research, 2020
A new coronavirus SARS-CoV-2, also called novel coronavirus 2019 (2019-nCoV), started to circulate among humans around December 2019, and it is now widespread as a global pandemic.
Chunlong Ma, M. Sacco, B. Hurst, J. A. Townsend, Yanmei Hu, Tommy Szeto, Xiujun Zhang, Bart Tarbet, M. Marty, Yu Chen, Jun Wang   +10 more
semanticscholar   +1 more source

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Nature Communications, 2020
The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to expand. Papain-like protease (PLpro) is one of two SARS-CoV-2 proteases potentially targetable with antivirals.
J. Osipiuk, S. Azizi, Steve Dvorkin, M. Endres, R. Jedrzejczak, Krysten A. Jones, Soowon Kang, R. Kathayat, Youngchang Kim, V. Lisnyak, S. Maki, V. Nicolaescu, Cooper A. Taylor, C. Tesar, Yu-an Zhang, Zhiyao Zhou, G. Randall, K. Michalska, S. Snyder, B. Dickinson, A. Joachimiak   +20 more
semanticscholar   +1 more source

Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms

Frontiers in Microbiology, 2020
Biofilms formed by the fungal pathogen Candida albicans are resistant to many of the antifungal agents commonly used in the clinic. Previous reports suggest that protease inhibitors, specifically inhibitors of aspartyl proteases, could be effective ...
Matthew B. Lohse, Matthew B. Lohse, Megha Gulati, Charles S. Craik, Alexander D. Johnson, Clarissa J. Nobile   +5 more
doaj   +1 more source

Binding site analysis of potential protease inhibitors of COVID-19 using AutoDock

VirusDisease, 2020
Recent outbreak of COVID-19 caused by SARS-CoV-2 in December 2019 raised global health concerns. Re-purposing the available protease inhibitor drugs for immediate use in treatment in SARS-CoV-2 infections could improve the currently available clinical ...
D. Mothay, K. V. Ramesh
semanticscholar   +1 more source

Putative Inhibitors of SARS-CoV-2 Main Protease from A Library of Marine Natural Products: A Virtual Screening and Molecular Modeling Study

Marine Drugs, 2020
The current emergency due to the worldwide spread of the COVID-19 caused by the new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a great concern for global public health.
Davide Gentile, Vincenzo Patamia, A. Scala, M. Sciortino, A. Piperno, A. Rescifina   +5 more
semanticscholar   +1 more source