Results 11 to 20 of about 1,229,602 (196)

Exploring the Potential of Bacillus Species Secondary Metabolites as SARS-CoV-2 Protease Inhibitors [PDF]

Journal of Pure and Applied Microbiology
Virus has the ability to cause health problems and even death in humans. Therefore, this review aims to assess the potential of metabolites derived from Bacillus species as viral protease inhibitors, specifically targeting Mpro/3CLpro and PLpro, in SARS ...
Yuniar Mulyani, Yeni Mulyani, Mochamad Untung K. Agung, Dian Yuni Pratiwi   +3 more
doaj   +2 more sources

HIV protease inhibitors: a review of molecular selectivity and toxicity

HIV/AIDS: Research and Palliative Care, 2015
Zhengtong Lv,* Yuan Chu,* Yong Wang Department of Immunology, School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha, Hunan, People's Republic of China *Both authors contributed equally to this work ...
Lv Z, Chu Y, Wang Y
doaj   +1 more source

Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB [PDF]

, 2013
Cysteine proteases of the papain superfamily are present in nearly all eukaryotes. They play pivotal roles in the biology of parasites and inhibition of cysteine proteases is emerging as an important strategy to combat parasitic diseases such as sleeping
Mottram, Jeremy C, Coombs, Graham H, Schröder, Jörg, Marhöfer, Richard J, Noack, Sandra, Selzer, Paul M   +5 more
core   +4 more sources

Protease inhibitors

, 2008
Protease inhibitors prevent maturation of viral proteins inside HIV particlesComponente Curricular::Educação Superior::Ciências da ...
STRANIX BRENT RICHARD, LAVALLEE JEAN-FRANCOIS, LEBERRE NICOLAS, PERRON VALERIE, HERBART DOMINIK, MILOT GUY, PANCHAL CHANDRA J   +6 more
openaire   +5 more sources

Potential COVID-19 Protease Inhibitors: Repurposing FDAapproved Drugs [PDF]

, 2020
Using as a template the crystal structure of COVID-19 protease, we developed a pharmacophore of functional centers of the protease inhibitor-binding pocket. Then we conducted data mining of the conformational database of FDA-approved drugs.
Valentina, Kouznetsova, Igor F., Tsigelny, David, Huang   +2 more
core   +1 more source

Lipopeptides as dimerization inhibitors of HIV-1 protease [PDF]

, 1999
In AIDS therapy, attempts have been made to inhibit the virus-encoded enzymes, e.g, HIV-1 protease, using active site-directed inhibitors. This approach is questionable, however, due to virus mutations and the high toxicity of the drugs, An alternative ...
Schramm, W., Schramm, H. J., Büttner, J., de Rosny, E., Dick, A., Reboud-Ravaux, M.   +5 more
core   +1 more source

Protease mediated maturation of HIV: Inhibitors of protease and the maturation process [PDF]

, 2012
Protease-mediated maturation of HIV-1 virus particles is essential for virus infectivity. Maturation occurs concomitant with immature virus particle release and is mediated by the viral protease (PR), which sequentially cleaves the Gag and Gag-Pol ...
Catherine S. Adamson, Adamson, Catherine S, Adamson, Catherine S; id_orcid   +2 more
core   +1 more source

HIV-1 protease inhibitor mutations affect the development of HIV-1 resistance to the maturation inhibitor bevirimat

Retrovirology, 2011
Background Maturation inhibitors are an experimental class of antiretrovirals that inhibit Human Immunodeficiency Virus (HIV) particle maturation, the structural rearrangement required to form infectious virus particles.
Konvalinka Jan, Maas Renée EM, Schipper Pauline J, Pokorná Jana, van Maarseveen Noortje M, Fun Axel, Nijhuis Monique   +6 more
doaj   +1 more source

High failure rates of protease inhibitor-based antiretroviral treatment in rural Tanzania - A prospective cohort study.

PLoS ONE, 2020
BACKGROUND:Poor adherence to antiretroviral drugs and viral resistance are the main drivers of treatment failure in HIV-infected patients. In sub-Saharan Africa, avoidance of treatment failure on second-line protease inhibitor therapy is critical as ...
Rahel E Bircher, Alex J Ntamatungiro, Tracy R Glass, Dorcas Mnzava, Amina Nyuri, Herry Mapesi, Daniel H Paris, Manuel Battegay, Thomas Klimkait, Maja Weisser, KIULARCO study group   +10 more
doaj   +1 more source

Differences in the Inhibitory Specificity Distinguish the Efficacy of Plant Protease Inhibitors on Mouse Fibrosarcoma

Plants, 2021
Metastasis, the primary cause of death from malignant tumors, is facilitated by multiple protease-mediated processes. Thus, effort has been invested in the development of protease inhibitors to prevent metastasis.
Sonia Yoo Im, Camila Ramalho Bonturi, Adriana Miti Nakahata, Clóvis Ryuichi Nakaie, Arnildo Pott, Vali Joana Pott, Maria Luiza Vilela Oliva   +6 more
doaj   +1 more source