Results 11 to 20 of about 2,078,222 (292)

Impact of angiotensin converting enzyme inhibition on post- coronary artery bypass interleukin 6 release [PDF]

, 2002
Background: Angiotensin 1 converting enzyme (ACE) inhibitors reduce morbidity and mortality after coronary artery bypass graft surgery (CABG). This benefit may result from an anti- inflammatory action.
Humphries, S.E., Rumley, A., Lowe, G.D., Montgomery, H.E., Sanders, J., Brull, D.J.   +5 more
core   +8 more sources

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors

Exploration of Targeted Anti-tumor Therapy, 2023
Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma.
Markus Schweipert, Anuja Amurthavasan, Franz-Josef Meyer-Almes   +2 more
doaj   +1 more source

Flavivirus enzymes and their inhibitors

, 2021
Flaviviruses such as dengue, Japanese encephalitis, West Nile, Yellow Fever and Zika virus, cause viral hemorrhagic fever and encephalitis in humans. However, antiviral therapeutics to treat or prevent flavivirus infections are not yet available. Thus, there is pressing need to develop therapeutics and vaccines that target flavivirus infections.
Ekaterina, Knyazhanskaya, Marc C, Morais, Kyung H, Choi   +2 more
openaire   +3 more sources

Phage display-derived inhibitor of the essential cell wall biosynthesis enzyme MurF [PDF]

, 2008
Background To develop antibacterial agents having novel modes of action against bacterial cell wall biosynthesis, we targeted the essential MurF enzyme of the antibiotic resistant pathogen Pseudomonas aeruginosa.
Sanschagrin, François, Tom Clarke, Catherine Paradis-Bleau, Blewett, Ann, Roger C Levesque, Clark, Tom, Paradis-Bleau , Catherine, Ann Blewett, Adrian Lloyd, Levesque, Roger C., Lloyd, Adrian, François Sanschagrin, Timothy DH Bugg, Bugg, Tim   +13 more
core   +1 more source

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages [PDF]

, 2012
Latent M. tuberculosis infection presents one of the major obstacles in the global eradication of tuberculosis (TB). Cholesterol plays a critical role in the persistence of M. tuberculosis within the macrophage during latent infection.
Russell, AJ, Edith Sim, Staunton, D, Angela J Russell, Staunton David, Russell Angela J., Areej Abuhammad (106459), Staunton, David, Westwood, IM, Stephen G Davies, Seden Peter T., Elizabeth Fullam (106463), Davies, Stephen G, Bhakta, Sanjib, Lowe, Edward D., Sim, Edith, David Staunton, Edward D. Lowe (106466), Akane Kawamura (50084), Seden, PT, Lowe, ED, Sim, E, Fullam Elizabeth, Fullam, Elizabeth, Garman, Elspeth F., Abuhammad Areej, Russell, Angela J, David L Wilson, Westwood Isaac M., Elspeth F Garman, Abuhammad, Areej, Davies, Stephen G., Davies, Stephen, Garman Elspeth F., Garman, Elspeth, Seden, Peter T, Kawamura, A, Sanjib Bhakta (106475), Elspeth F. Garman (106483), Fullam, E, Bhakta, S, Westwood, Isaac M, Garner, Alun Christopher, Russell, Angela J., Lowe Edward D., Garner, AC, Isaac M Westwood, Kawamura Akane, Bhakta Sanjib, Westwood, Isaac, Garner Alun Christopher, Akane Kawamura, Alun Christopher Garner (106477), Seden, Peter T., Alun Christopher Garner, Kawamura, Akane, Abuhammad, A, Elizabeth Fullam, Lowe, Edward D, Isaac M. Westwood (106473), David L. Wilson (74373), Angela J. Russell (106482), Wilson, DL, Davies, SG, Edward D Lowe, Wilson, David L., Peter T. Seden (106479), Wilson, David L, Sanjib Bhakta, Peter T Seden, Davies Stephen G., Garman, EF, Edith Sim (50087), Wilson David L., Stephen G. Davies (106481), Areej Abuhammad, David Staunton (106470), Garman, Elspeth F, Sim Edith   +78 more
core   +2 more sources

The angiotensin-converting enzyme (ACE) gene family of Anopheles gambiae [PDF]

, 2005
Background Members of the M2 family of peptidases, related to mammalian angiotensin converting enzyme (ACE), play important roles in regulating a number of physiological processes.
Lee, A.J., Smith Judith A, Lee, Alison J., Shirras Alan D, Shirras, A.D., Smith, Judith A., Isaac, R.E., Shirras, Alan D., Isaac R Elwyn, Burnham Susan, Smith, J.A., Burnham, Susan, Burnham, S., Lee Alison J, Isaac, R. Elwyn   +14 more
core   +6 more sources

Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 Inhibitors

Molecules, 2018
We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1.
Rosana Leiva, Andrew McBride, Margaret Binnie, Scott P. Webster, Santiago Vázquez   +4 more
doaj   +1 more source

Harnessing the Bioactive Potential of Limonium spathulatum (Desf.) Kuntze: Insights into Enzyme Inhibition and Phytochemical Profile

Plants, 2023
This study assessed the halophyte species Limonium spathulatum (Desf.) as a possible source of natural ingredients with the capacity to inhibit enzymes related to relevant human health disorders and food browning.
Seria Youssef, Luisa Custódio, Maria João Rodrigues, Catarina G. Pereira, Ricardo C. Calhelha, József Jekő, Zoltán Cziáky, Karim Ben Hamed   +7 more
doaj   +1 more source

The structure of testis angiotensin-converting enzyme (tACE-g13) in complex with the inhibitor RXPA380 [PDF]

, 2006
Includes bibliographical references.Angiotensin-converting enzyme (ACE), a zinc metalloprotease, is a key regulator of the mammalian renin-angiotensin system (RAS) Primarily, ACF is a dipeptidl peptidase which cleaves angiotensin I to produce angiotensin
Chitapi, Itai
core   +1 more source