Results 11 to 20 of about 1,152,447 (302)

Selective inhibition of carotenoid cleavage dioxygenases : phenotypic effects on shoot branching [PDF]

, 2009
Members of the carotenoid cleavage dioxygenase family catalyse the oxidative cleavage of carotenoids at various chain positions, leading to the formation of a wide range of apocarotenoid signalling molecules.
Auldridge, Zeevaart, Schwartz, von Lintig, Wyss, Kiefer, Hu, Dudareva, Bouvier, Juttner, Kloer, Marasco, Eisner, Fester, Matusova, Akiyama, Gomez-Roldan, Umehara, Ward, Sorefan, Booker, Schwartz, Alder, Booker, Bennett, Cunningham, Schwartz, Stockwell, Armstrong, Kaschani, Han, Kitahata, Suzuki, Han, Bergeron, Kawase, Schmidt, Cunningham, Wilson, Chatfield, Taylor, Borowski, Kontogiorgis, Simkin, Burbidge, Vogel, Paik, Scherzinger, Bouvier, Quinlan, Walter, Yeh, Alija   +52 more
core   +1 more source

The Fellowship of Privileged Scaffolds—One Structure to Inhibit Them All

Pharmaceuticals, 2021
Over the past few years, the application of privileged structure has emerged as a powerful approach to the discovery of new biologically active molecules.
Marcin Skoreński, Marcin Sieńczyk
doaj   +1 more source

The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum [PDF]

, 2004
The discovery of a potentially novel proline-specific peptidase from bovine serum is presented which is capable of cleaving the dipeptidyl peptidase IV (DPIV) substrate Gly-Pro-MCA.
Abbott, Birney, Cunningham, De Meester, De Meester, Duke-Cohan, Duke-Cohan, Duke-Cohan, Durinx, Gilmartin, Hegen, Hopsu-Havu, Huang, Iwaki-Egawa, Kin, Laemmli, Malik, Mentlein, Mentlein, Ohkubo, Ohnishi, Pineiro-Sanchez, Scanlan, Schon, Sedo, Sedo, Shibuya-Saruta, Smith, Stockel-Maschek, Underwood, Yaron, Yoshimoto   +31 more
core   +1 more source

Natural Products from Medicinal Plants with Anti-Human Coronavirus Activities

Molecules, 2021
Since the emergence of severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) first reported in Wuhan, China in December 2019, COVID-19 has spread to all the continents at an unprecedented pace.
Salar Hafez Ghoran, Mohamed El-Shazly, Nazim Sekeroglu, Anake Kijjoa   +3 more
doaj   +1 more source

Immobilized enzyme reactors in HPLC and its application in inhibitor screening: A review

Journal of Pharmaceutical Analysis, 2012
This paper sets out to summarize the literatures based on immobilized enzyme bio-chromatography and its application in inhibitors screening in the last decade.
Si-Meng Fang, Hai-Na Wang, Zhong-Xi Zhao, Wei-Hong Wang   +3 more
doaj   +1 more source

In Vitro Enzymatic Studies Reveal pH and Temperature Sensitive Properties of the CLIC Proteins

Biomolecules, 2023
Chloride intracellular ion channel (CLIC) proteins exist as both soluble and integral membrane proteins, with CLIC1 capable of shifting between two distinct structural conformations. New evidence has emerged indicating that members of the CLIC family act
Amani Alghalayini, Khondker Rufaka Hossain, Saba Moghaddasi, Daniel R. Turkewitz, Claudia D’Amario, Michael Wallach, Stella M. Valenzuela   +6 more
doaj   +1 more source

A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

EMBO Molecular Medicine, 2012
Translational read‐through‐inducing drugs (TRIDs) promote read‐through of nonsense mutations, placing them in the spotlight of current gene‐based therapeutic research.
Tobias Goldmann, Nora Overlack, Fabian Möller, Valery Belakhov, Michiel van Wyk, Timor Baasov, Uwe Wolfrum, Kerstin Nagel‐Wolfrum   +7 more
doaj   +1 more source

S-Ethyl-Isothiocitrullin-Based Dipeptides and 1,2,4-Oxadiazole Pseudo-Dipeptides: Solid Phase Synthesis and Evaluation as NO Synthase Inhibitors

Molecules, 2023
We previously reported dipeptidomimetic compounds as inhibitors of neuronal and/or inducible NO synthases (n/iNOS) with significant selectivity against endothelial NOS (eNOS).
Elodie Mauchauffée, Jérémy Leroy, Jihanne Chamcham, Abdelaziz Ejjoummany, Manon Maurel, Lionel Nauton, Booma Ramassamy, Karima Mezghenna, Jean-Luc Boucher, Anne-Dominique Lajoix, Jean-François Hernandez   +10 more
doaj   +1 more source

Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance

Medicines, 2017
Background: Pathogenic yeasts resistance to current drugs emphasizes the need for new, safe, and cost-effective drugs. Also, new inhibitors are needed to control the effects of enzymes that are implicated in metabolic dysfunctions such as cancer, obesity,
Marthe Aimée Tchuente Tchuenmogne, Thierry Ngouana Kammalac, Sebastian Gohlke, Rufin Marie Toghueo Kouipou, Abdulselam Aslan, Muslum Kuzu, Veysel Comakli, Ramazan Demirdag, Silvère Augustin Ngouela, Etienne Tsamo, Norbert Sewald, Bruno Ndjakou Lenta, Fabrice Fekam Boyom   +12 more
doaj   +1 more source

Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I ...
Farhat Ramzan, Syed Ayaz Nabi, Mehak Saba Lone, Alessandro Bonardi, Aabid Hamid, Sameena Bano, Kalicharan Sharma, Syed Shafi, Mohammed Samim, Kalim Javed, Claudiu T. Supuran   +10 more
doaj   +1 more source