Results 11 to 20 of about 19,152,238 (244)

Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies [PDF]

Haematologica, 2014
The phosphoinositide 3-kinase pathway represents an important anticancer target because it has been implicated in cancer cell growth, survival, and motility. Recent studies show that PI3K may also play a role in the development of resistance to currently
Elias Jabbour, Oliver G. Ottmann, Michael Deininger, Andreas Hochhaus   +3 more
doaj   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation. [PDF]

Mol Oncol
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Xenou L, Tzenaki N, Tsapara A, Tzardi M, Papakonstanti EA.   +4 more
europepmc   +2 more sources

Proteomic investigation of the class IA phosphoinositide 3-kinase signalling pathway [PDF]

, 2012
PhDClass IA phosphoinositide 3-kinases (PI3Ks) are a family of enzymes with key roles in the regulation of signalling pathways, many of which are mediated through Akt.
Beltran, Luisa
core   +4 more sources

Immunodeficiency due to a novel variant in PIK3CD: a case report

Pediatric Rheumatology Online Journal, 2023
Background Primary immunodeficiencies are immunological disorders caused by gene mutations involved in immune system development and activation. Recently, activated phosphoinositide 3-kinase delta syndrome (APDS) due to mutations in the phosphoinositide ...
Niloofar Shashaani, Zahra Chavoshzadeh, Leila Ghasemi, Shabnam Hajiani Ghotbabadi, Sara Shiari, Samin Sharafian, Reza Shiari   +6 more
doaj   +1 more source

Overview of Research into mTOR Inhibitors

Molecules, 2022
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that belongs to the phosphoinositide 3-kinase (PI3K)-related kinase (PIKK) family.
Beibei Mao, Qi Zhang, Li Ma, Dong-Sheng Zhao, Pan Zhao, Peizheng Yan   +5 more
doaj   +1 more source

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]

, 2014
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Ward, Richard, Davies, Paul; id_orcid, Bago, Ruzica, Shpiro, Natalia, Cross, Darren, Sommer, Eeva, Malik, Nazma, Ganley, Ian G.; id_orcid, Munson, Michael J., Alessi, Dario R.; id_orcid, Prescott, Alan R.; id_orcid   +10 more
core   +1 more source

Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer [PDF]

, 2011
The phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases, which are implicated in signal transduction pathways and modulation of fundamental cellular activities such as cell growth, proliferation, differentiation, motility, survival and
Cmiljanović, Nataša
core   +1 more source

CDK4/6 Inhibitors-based Combinational Therapy for Human Cancers

Zhongliu Fangzhi Yanjiu, 2019
Cyclin-dependent kinases (CDKs) inhibitors have been approved in the combination with hormone-based therapy for advanced breast cancer. In addition to endocrine therapy, the combinations of CDK4/6 inhibitors with epidermal growth factor receptor (EGFR ...
ZHANG Baihong, YUE Hongyun
doaj   +1 more source

The Wnt/β-catenin and PI3K/Akt signaling pathways promote EMT in gastric cancer by epigenetic regulation via H3 lysine 27 acetylation

Tumor Biology, 2017
In this study, we investigated the underlying mechanism of the phosphoinositide 3-kinase/Akt– and Wnt/β-catenin-mediated promotion of epithelial-to-mesenchymal transition by epigenetic regulation of histone acetylation in gastric cancer.
Yue Song, Zhao-xia Li, Xi Liu, Rui Wang, Li-wei Li, Qingyu Zhang   +5 more
doaj   +1 more source

A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation [PDF]

, 2009
Background: The fibroblast growth factors (FGFs) are key regulators of embryonic development, tissue homeostasis and tumour angiogenesis. Binding of FGFs to their receptor(s) results in activation of several intracellular signalling cascades including ...
Maffucci, Tania, Dominguez, V., Tania Maffucci, Gianluca Sala, Raimondi C, Dominguez V, Dominguez Veronica, Abu-Hayyeh S, Zachary I, Falasca Marco, Raimondi Claudio, Sala, Gianluca, Claudio Raimondi, Maffucci Tania, Abu-Hayyeh, Shadi, Falasca, Marco, Zachary, Ian, Raimondi, C, Sala, G, Abu-Hayyeh, S, Veronica Dominguez, Zachary, I., Falasca M, Maffucci T, Maffucci, T, Ian Zachary, Dominguez, Veronica, Sala G, Falasca, M, Sala Gianluca, Shadi Abu-Hayyeh, Marco Falasca, Maffucci, T., Sala, G., Abu-Hayyeh Shadi, Raimondi, C., Dominguez, V, Zachary, I, Raimondi, Claudio, Zachary Ian, Abu-Hayyeh, S.   +40 more
core   +1 more source