Results 1 to 10 of about 532,120 (306)

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Badura, Susanne, Falkenburg, J. H. Frederik, Liebermann, Marcus, Nijmeijer, Bart A., Ottmann, Oliver Gerhard, Pfeifer, Heike, Ruthardt, Martin, Tesanovic, Tamara, Wystub, Sylvia   +8 more
core   +20 more sources

Estradiol inhibits phosphorylation of JAK/STAT, PI3K/AKT and expression of IL-17A in mouse mononuclear cells treated with IL-36β

Pifu-xingbing zhenliaoxue zazhi, 2023
Objective To investigate the effects of β-estradiol (E2) on the phosphorylation of JAK/STAT, PI3K/AKT signaling pathways and the expression of IL-17A in mouse spleen mononuclear cells treated with IL-36β. Methods The spleens were isolated from female SPF
Shuang LIU, Shanshan YANG, Chunchan ZHENG, Sujun LUO, Na WEI, Sirui LI, Jianqiang SHI, Rongyi CHEN   +7 more
doaj   +1 more source

Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity

eLife, 2022
Background: Notch signaling dictates cell fate decisions in mammalian cells including megakaryocytes. Existence of functional Notch signaling in enucleate platelets remains elusive.
Susheel N Chaurasia, Mohammad Ekhlak, Geeta Kushwaha, Vipin Singh, Ram L Mallick, Debabrata Dash   +5 more
doaj   +1 more source

Characterization of Cutaneous Adverse Events Associated With PI3K Inhibitors in 11 Patients [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
Introduction: Phosphoinositide 3-kinase (PI3K) inhibitors are a new class of cancer therapeutics that inhibits one or more enzymes in the PI3K/AKT/mTOR tumor growth pathway.
Padmavathi V. Karri, Benjamin D. Freemyer, Omar Pacha, Anisha B. Patel   +3 more
doaj   +1 more source

Berberine Supplement and Resistance Training May Ameliorate Diazinon Induced Neural Toxicity in Rat Hippocampus Via the Activation of the TrkB and ERK Signaling Pathway

International Clinical Neuroscience Journal, 2020
Background: Diazinon is an organophosphate pesticide that is broadly applied to control insects which causes oxidative damages in hippocampus tissue.
Elham Shakouri, Mohammad Ali Azarbayjani, Seyed Behnamedin Jameie, Maghsoud Peeri, Mona Farhadi   +4 more
doaj   +1 more source

Cortactin Could Regulate Proliferation and Apoptosis of Esophageal Squamous Carcinoma Cells Through PI3K-AKT Pathway

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the effects and potential regulatory mechanisms of Cortactin (CTTN) on the proliferation and apoptosis of esophageal squamous cell carcinoma (ESCC).
ZHANG Jiuna, ZHAI Shan, LI Xiaotian
doaj   +1 more source

PI3K and Notch signaling pathway play a synergistic regulatory role in the proliferation and activation of CD4+T cells in peripheral blood of patients with psoriasis vulgaris

Pifu-xingbing zhenliaoxue zazhi, 2022
Objective To study effects of phosphoinositide 3 kinase (PI3K) and Notch signaling pathway on the proliferation and activation of CD4+ T cells in peripheral blood of patients with psoriasis vulgaris.
Jia LIU, Ming WEI
doaj   +1 more source

PI3K Pathway in NSCLC [PDF]

Frontiers in Oncology, 2012
The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3'-hydroxyl group of phosphatidylinositol and phosphoinositides. PI3K regulate signaling pathways for neoplasia, including cell proliferation, adhesion, survival, and motility.
Martinez-Martí, Alex, Felip, Enriqueta
openaire   +3 more sources

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Gut Microbes, 2021
The mammalian target of rapamycin (mTOR) and the phosphatidylinositol-3-kinase (PI3K)/protein kinase B or Akt (PKB/Akt) signaling pathways are considered as two but somewhat interconnected significant immune pathways which play complex roles in a variety
Amir Hossein Mohseni, Vincenzo Casolaro, Luis G. Bermúdez-Humarán, Hossein Keyvani, Sedigheh Taghinezhad-S   +4 more
doaj   +1 more source

Mechanistic analysis of endothelial lipase G promotion of the occurrence and development of cervical carcinoma by activating the phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B/mechanistic target of rapamycin kinase signalling pathway

Journal of Obstetrics and Gynaecology, 2023
Lipase G, endothelial type (LIPG) is expressed abundantly in tissues with a high metabolic rate and vascularisation. Research on LIPG has focussed on metabolic syndromes.
Jing Huang, Renci Liu, Yiwen Zhang, Xiujie Sheng   +3 more
doaj   +1 more source