Results 41 to 50 of about 390,020 (313)

Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model

Translational Neuroscience, 2021
Owing to neurite promoting, antioxidant and anti-inflammatory effects of Euxanthone (Eux), the investigation was aimed to probe the neuroprotective efficacy of Eux against traumatic spinal cord injury (t-SCI) in rats and whether Eux can improve ...
Yao Rubin, Ren Lirong, Wang Shiyong, Zhang Ming, Yang Kaishun   +4 more
doaj   +1 more source

SMER28 Attenuates PI3K/mTOR Signaling by Direct Inhibition of PI3K p110 Delta

Cells, 2022
SMER28 (Small molecule enhancer of Rapamycin 28) is an autophagy-inducing compound functioning by a hitherto unknown mechanism. Here, we confirm its autophagy-inducing effect by assessing classical autophagy-related parameters. Interestingly, we also discovered several additional effects of SMER28, including growth retardation and reduced G1 to S phase
Marco Kirchenwitz, Stephanie Stahnke, Silvia Prettin, Malgorzata Borowiak, Laura Menke, Christian Sieben, Carmen Birchmeier, Klemens Rottner, Theresia E. B. Stradal, Anika Steffen   +9 more
openaire   +3 more sources

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Oliver G Ottmann, Martin Ruthardt, Oliver G. Ottmann, Oliver G. Ottmann (485229), Falkenburg, J.H.F., Marcus Liebermann (485228), Bart A. Nijmeijer (485227), Pfeifer, Heike, Falkenburg, J. H. Frederik, J. H. Frederik Falkenburg, Ruthardt, Martin, Tamara Tesanovic, Tesanovic, Tamara, Bart A Nijmeijer, Heike Pfeifer, Ottmann, Oliver G., Susanne Badura (485223), Sylvia Wystub, Sylvia Wystub (485226), Liebermann, M., Marcus Liebermann, Bart A. Nijmeijer, Ottmann, O.G., Nijmeijer, Bart A., Badura, S., Susanne Badura, Wystub, Sylvia, Pfeifer, H., J H Frederik Falkenburg, Tamara Tesanovic (485224), Martin Ruthardt (66634), Wystub, S., Nijmeijer, B.A., Ruthardt, M., Tesanovic, T., Badura, Susanne, Heike Pfeifer (485225), J. H. Frederik Falkenburg (210432), Liebermann, Marcus   +38 more
core   +1 more source

PI3K-Akt signaling pathway (hsa04151) highlighted with variants of uncertain significance (VUS)-containing genes from the Hong Kong and Shanghai cohorts.

, 2022
(A) The overlapping VUS-containing genes in PI3K-Akt signaling pathway in two cohorts were summarized in the Venn diagram. (B) VUS-containing genes appeared in both cohorts, in only Hong Kong cohort and in only Shanghai cohort were highlighted in green ...
Yonghao Liang (3933299), Qin Cao (802896), Jeremy Yuen-Chun Teoh (10408316), Yu Wei (365236), Yao Zhu (441601), Qing Xiong (136442), Stephen Kwok-Wing Tsui (9358976), Yim-Ping Wong (13775411), Peter Ka-Fung Chiu (12514172), Ding-Wei Ye (104627), Lin Wang (11986), Chi-Fai Ng (3105801)   +11 more
core   +1 more source

Plinabulin exerts an anti-proliferative effect via the PI3K/AKT/mTOR signaling pathways in glioblastoma [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Plinabulin, a marine-derived anticancer drug targeting microtubules, exhibits anti-cancer effects on glioblastoma cells. However, its therapeutic potential, specifically for glioblastoma treatment, remains underexplored.
Rouxin Wang, Jing Cheng, Huanqi Zhang, Kaizhi Luo, Rui Wu, Yangling Li, Yuanheng Zhu, Chong Zhang   +7 more
doaj   +1 more source

Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway [PDF]

Cell Reports, 2018
Unequal transmission of nutritive signaling during cell division establishes fate disparity between sibling lymphocytes, but how asymmetric signaling becomes organized is not understood. We show that receptor-associated class I phosphatidylinositol 3-kinase (PI3K) signaling activity, indexed by phosphatidylinositol (3,4,5)-trisphosphate (PIP3) staining,
Chen, Yen-Hua, Kratchmarov, Radomir, Lin, Wen-Hsuan W., Rothman, Nyanza J., Yen, Bonnie, Adams, William C., Nish, Simone A., Rathmell, Jeffrey C., Reiner, Steven L.   +8 more
openaire   +4 more sources

PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells

, 2012
We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis ...
Dittmann, Kai, Ridzewski, Rosalie, Diana Marklein (105976), Albert Rosenberger (28881), Diana Marklein, Kai Dittmann (105997), Simone Fulda, Rosalie Ridzewski, Jürgen Wienands, Ulrike Graab, Wienands, Juergen, Simone Fulda (106002), Graab, Ulrike, Frauke Nitzki, Nitzki, Frauke, Rosenberger, Albert, Tiandong Yan, Kai Dittmann, Yan, Tiandong, Yan, T., Heidi Hahn (106003), Naumann, Ivonne, Heidi Hahn, Fulda, Simone, Ivonne Naumann, Wienands, Jürgen, Ivonne Naumann (105981), Leszek Wojnowski (106001), Wojnowski, Leszek, Marklein, Diana, Ulrike Graab (105978), Tiandong Yan (105985), Jürgen Wienands (105999), Hahn, Heidi, Albert Rosenberger, Frauke Nitzki (105993), Leszek Wojnowski, Rosalie Ridzewski (105989)   +37 more
core   +1 more source

Image_4_LncRNA NCAL1 potentiates natural killer cell cytotoxicity through the Gab2-PI3K-AKT pathway.tif

, 2022
Natural killer (NK) cells perform immune surveillance functions in tumors. The antitumor effects of NK cells are closely related to tumor occurrence and development.
Lei Zhou (19808), Min Li (12799), Yongchong Chen (10869756), Xiaoying Zhang (52883), Ji-fan Hu (13872578), Jiuwei Cui (558808), Xin Zhou (54275), Jianting Xu (4262554), Yufeng Wang (274657), Chao Niu (398203), Shan Zhu (211916), Zhaozhi Li (6206048)   +11 more
core   +1 more source

Vortioxetine exhibits anti-glioblastoma activity via the PI3K-Akt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Glioblastoma multiforme (GBM) presents a significant challenge in oncology due to its highly aggressive nature and inherent resistance to conventional therapeutic interventions.
Huan-Qi Zhang, Dao-Ming Zhang, Zhi-Zhen Huang, Jing Cheng, Chong Zhang, Neng-Ming Lin, Yang-Ling Li   +6 more
doaj   +1 more source

Hypoxia regulates human mast cell adhesion to fibronectin via the PI3K/AKT signaling pathway

Cell Adhesion & Migration, 2020
A decrease in oxygen concentration is a hallmark of inflammatory reactions resulting from infection or homeostasis disorders. Mast cells interact with extracellular matrix and other cells by adhesion receptors.
Joanna Pastwińska, Aurelia Walczak-Drzewiecka, Magdalena Łukasiak, Marcin Ratajewski, Jarosław Dastych   +4 more
doaj   +1 more source