Results 21 to 30 of about 415,144 (305)
PI3K inhibition enhances doxorubicin-induced apoptosis in sarcoma cells [PDF]
, 2012 We searched for a drug capable of sensitization of sarcoma cells to doxorubicin (DOX). We report that the dual PI3K/mTOR inhibitor PI103 enhances the efficacy of DOX in several sarcoma cell lines and interacts with DOX in the induction of apoptosis ...
Dittmann, Kai +37 more
core +1 more source
β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): β-LAPachone (B-LAP) is a natural product with established anti-inflammatory properties. In this study, we investigated the protective potential of B-LAP against diabetic nephropathy in streptozotocin (STZ) induced diabetic mice.Materials ...
Davoud Sanajou +2 more
doaj +1 more source
Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer [PDF]
, 2011 The phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases, which are implicated in signal transduction pathways and modulation of fundamental cellular activities such as cell growth, proliferation, differentiation, motility, survival and
Cmiljanović, Nataša
core +1 more source
The role of P13K p1168 in the regulation of gene expression in murine macrophages. [PDF]
, 2012 PhDPI3K are a family of lipid kinase enzymes that are involved in a broad spectrum of cellular, physiological and pathological processes. Notably, PI3K dysfunction is associated with cancer, inflammation and metabolism. The PI3K family consists of three
Burns, Emily
core +4 more sources
Autophagy Reports, 2022 The elimination of organelles to create the lens organelle-free zone (OFZ) is a macroautophagy/autophagy-dependent mechanism that occurs without causing cell death.
A. Sue Menko
doaj +1 more source
The PTEN–PI3K Axis in Cancer [PDF]
Biomolecules, 2019 The PI3K–AKT–mTOR signal transduction pathway regulates a variety of biological processes including cell growth, cell cycle progression and proliferation, cellular metabolism, and cytoskeleton reorganization. Fine-tuning of the phosphatidylinositol 3-kinase (PI3K) pathway signaling output is essential for the maintenance of tissue homeostasis and ...
Papa A., Pandolfi P. P.
openaire +3 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target.
Xinyuan Xu +6 more
doaj +1 more source
RNA virus modulation of IFN, PI3K and apoptosis [PDF]
, 2009 Interferon (IFN) and phosphatidylinositol 3-kinase (PI3K) are apoptosis regulators that are targeted by viruses to promote survival of infected cells.
Killip, Marian J.
core +2 more sources
Drug Design, Development and Therapy, 2022 Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S. Drug Des Devel Ther. 2019;13:3171–3180. The authors have advised due to an error that occurred inadvertently at the time of figure assembly, Figure 5J is incorrect.
Zheng X +5 more
doaj
Endocrine Regulations, 2019 Objective. Ghrelin, a 28 amino acid peptide, has diverse physiological roles. Phosphatidylino-sitol-bisphosphate 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) are involved in some of the recognized actions of ghrelin. It has been shown that
Taherkhani Shokoufeh +4 more
doaj +1 more source