Results 1 to 10 of about 320,721 (362)
Expanding mTOR signaling [PDF]
Cell Research, 2007 The mammalian target of rapamycin (mTOR) has drawn much attention recently because of its essential role in cell growth control and its involvement in human tumorigenesis. Great endeavors have been made to elucidate the functions and regulation of mTOR in the past decade.
Kun-Liang Guan +2 more
exaly +3 more sources
1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Osteosarcoma is a major solid malignant tumor of bone, possessing significant burden on healthcare due to non-availability of specific anticancer agents.
Qing Su +3 more
doaj +1 more source
Protein intake and loss of proteostasis in the eldery [PDF]
The Ukrainian Biochemical Journal, 2021 Ageing is a process of declining bodily function and a major risk factor of chronic diseases. The declining bodily function in ageing can cause loss of proteostasis (protein homeostasis), which is a balance between protein synthesis, folding ...
A. N. Kirana +2 more
doaj +1 more source
Microgravity inhibits autophagy in human capillary endothelial cells in space flight
Autophagy Reports, 2022 Microgravity and space radiation (SR) are the two environmental factors that most affect human crews in space flight (SF). The endothelium is highly sensitive to gravitational unloading and several health problems reported by astronauts derive from ...
Ivana Barravecchia, Debora Angeloni
doaj +1 more source
Glia, 2017 AbstractMyelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination.
Gianluca Figlia +2 more
openaire +4 more sources
Autophagy Reports, 2022 Autophagy is a conserved intracellular degradation pathway that is essential for maintaining cellular homeostasis. Given its critical role in several disease conditions, recent studies are focussed on identifying drugs/small molecules with autophagy ...
Surendra Kumar Prajapat +4 more
doaj +1 more source
The Oncologist, 2010 AbstractInhibitors of mammalian target of rapamycin (mTOR) have been approved for the treatment of renal cell carcinoma and appear to have a role in the treatment of other malignancies. The primary objective of this drug review is to provide pharmacokinetic and dynamic properties of the commonly used drugs everolimus and temsirolimus.
Heinz-Josef, Klümpen +3 more
openaire +2 more sources
Neuron, 2014 The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular signaling hub that, like the nervous system itself, integrates internal and external cues to elicit critical outputs including growth control, protein synthesis, gene expression, and metabolic balance.
Lipton, Jonathan O., Sahin, Mustafa
openaire +2 more sources
Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy [PDF]
ACS Pharmacology & Translational Science, 2022 As an important regulator of cell metabolism, proliferation, and survival, mTOR (mammalian target of rapamycin) signaling provides both a potential target for cancer treatment and a research tool for investigation of cell metabolism. One inhibitor for both mTORC1 and mTORC2 pathways, OSI-027, exhibited robust anticancer efficacy but induced side ...
Tianyi Wang +8 more
openaire +2 more sources
Silencing of mTOR Facilitates the Cyclophosphamide-Mediated Cytotoxicity in Acute Lymphoblastic Leukemia [PDF]
ImmunoAnalysis, 2023 Background: Acute lymphoblastic leukemia (ALL) is a neoplastic disorder in which lymphoid progenitors of patients proliferate malignantly and accumulate in peripheral blood (PB), bone marrow (BM), and other sites.
Mohammad Sadeghi +6 more
doaj +1 more source