Results 21 to 30 of about 320,721 (362)
Quantitative phosphoproteomics reveal that mTOR regulates cell growth and proliferation by phosphorylating a functionally diverse set of substrates [PDF]
, 2012 The atypical Ser/Thr kinase target of rapamycin (TOR) is a central controller of cell growth and proliferation. TOR forms two distinct multiprotein complexes, TORC1 and TORC2, which are structurally and functionally conserved from yeast to humans.
Robitaille, Aaron M.
core +1 more source
Function of mTOR complex 1 and 2 in skeletal muscle [PDF]
, 2009 Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core +1 more source
Resveratrol-induced brown fat-like phenotype in 3T3-L1 adipocytes partly via mTOR pathway
Food & Nutrition Research, 2020 Background: Browning of white adipose tissues (WAT) is recognized as a novel way to combat obesity and its related comorbidities. Thus, a lot of dietary agents contributing to browning of WAT have been identified.
Zihui Liu +7 more
doaj +1 more source
Cellular Respiration in Thymic Fragments from Mice
Frontiers in Bioscience-Landmark, 2022 Background: This report aims to detail the use of the phosphorescence oxygen analyzer for in vitro investigation of thymic responses to pharmaceutical agents, in particular immunosuppressants and immunomodulators.
Mariam Alshamsi +3 more
doaj +1 more source
mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer [PDF]
ISRN Otolaryngology, 2012 Head and neck cancer is the sixth most common type of Cancer worldwide. Since conventional treatment regimens are nonselective and are associated with systemic toxicities, intense investigations focus on molecular targeted therapy with high selectivity and low adverse effects.
Wei Gao +4 more
openaire +2 more sources
The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence
Frontiers in Bioscience-Landmark, 2023 Aging and related diseases significantly affect the health and happiness index around the world. Cellular senescence is the basis of physiological aging and is closely related to various senile diseases.
Yukun Han +6 more
doaj +1 more source
Tuberous Sclerosis: A Rare Cause Section of Seizure in an Older Adult [PDF]
Journal of Clinical and Diagnostic Research, 2020 Tuberous sclerosis is a rare autosomal dominant genetic disorder caused by mutation of TCS1 or TCS2 gene. The birth incidence is estimated to be 1 in 6000.
Shubhransu Patro +3 more
doaj +1 more source
A novel Bcr-Abl–mTOR–eIF4A axis regulates IRES-mediated translation of LEF-1 [PDF]
Open Biology, 2014 Internal ribosome entry sites (IRESs) in cellular mRNAs direct expression of growth-promoting factors through an alternative translation mechanism that has yet to be fully defined.
Becky Pinjou Tsai +10 more
doaj +1 more source
Microbial Cell, 2019 Iron is an essential nutrient for immune cells and microbes, therefore the control of its homeostasis plays a decisive role for infections. Moreover, iron affects metabolic pathways by modulating the translational expression of the key tricarboxylic acid
Julia Telser +6 more
doaj +1 more source
Molecular & Cellular Oncology, 2019 Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle ...
Luca Drusian, Alessandra Boletta
doaj +1 more source