Molecular mechanisms of pain regulation in patients with osteoarthritis
Научно-практическая ревматология, 2016 Objective: to study the mechanisms determining the level of pain on the basis of an analysis of the expression profiles of the genes involved in joint destruction, inflammation, and metabolic regulation in the blood of patients with osteoarthritis (OA ...
E. V. Chetina +10 more
doaj +1 more source
Oxydative stress in type 2 diabetic patients: involvement of HIF-1 alpha AND mTOR genes expression [PDF]
The Ukrainian Biochemical Journal, 2023 Biochemical and genetic mechanisms of oxidative stress (OS) developing in the blood of patients with type 2 Diabetes mellitus (T2DM) were studied. Twenty patients with T2DM and 10 healthy persons participated in this study.
Y. A. Saenko +5 more
doaj +1 more source
mTOR inhibitors response and mTOR pathway in pancreatic neuroendocrine tumors [PDF]
Endocrine-Related Cancer, 2016 Medical therapy of pancreatic neuroendocrine tumors (P-NET) may take advantage of Everolimus treatment. However, the extent of therapeutic response cannot be predicted. This study was aimed to identify the possible predictive markers of response to Everolimus in P-NET. We found that Everolimus reduced the cell viability and induced apoptosis in primary
FALLETTA, Simona +11 more
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Phosphatidic acid: a lipid regulator of the Hippo pathway
Molecular & Cellular Oncology, 2019 The Hippo pathway, a signaling pathway highly conserved across species, plays a crucial role in organ size control and cancer suppression. Our recent study shows that phosphatidic acid can regulate the Hippo pathway through a physical lipid-protein ...
Han Han +3 more
doaj +1 more source
Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]
, 2015 Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Sumbayev, Vadim V. +22 more
core +1 more source
Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]
, 2007 This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
core +1 more source
The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]
, 2007 Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Brand, Stephan +7 more
core +1 more source
mTOR signaling in tumorigenesis [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014 mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase involved in regulating major cellular functions including growth and proliferation. Deregulation of the mTOR signaling pathway is one of the most commonly observed pathological alterations in human cancers.
Kai, Xu, Pengda, Liu, Wenyi, Wei
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Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]
, 2005 Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core +1 more source
mTOR regulation of autophagy [PDF]
FEBS Letters, 2010 Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily‐conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status ...
Jung, Chang Hwa +4 more
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