Results 11 to 20 of about 320,721 (362)
The protective effect of Apelin-13 against cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway.Materials and Methods: The phenylephrine-induced cardiomyocyte hypertrophy model was established in H9C2 cells in ...
Yu Peng +4 more
doaj +1 more source
JCRPE, 2021 Congenital hyperinsulinism (CHI) is the most common cause of severe, persistent hypoglycemia in neonates and infants. If the patient does not respond to medical treatment the currently available treatment is subtotal pancreatectomy, but some patients ...
Qiong Chen +7 more
doaj +1 more source
β-LAPachone is renoprotective in streptozotocin-induced diabetic mice via regulating the PI3K/Akt/mTOR signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): β-LAPachone (B-LAP) is a natural product with established anti-inflammatory properties. In this study, we investigated the protective potential of B-LAP against diabetic nephropathy in streptozotocin (STZ) induced diabetic mice.Materials ...
Davoud Sanajou +2 more
doaj +1 more source
mTOR Signaling in Metabolism and Cancer [PDF]
, 2020 The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and ...
core +1 more source
médecine/sciences, 2013 > Les troubles cognitifs occupent une place centrale dans la schizophrenie. Parfois severes, ils apparaissent precocement au cours de l’evolution de la pathologie et ont des consequences fonctionnelles importantes, notamment sur l’integration sociale et professionnelle des patients.
Philippe Marin +2 more
openaire +1 more source
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]
, 2012 Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian +1 more
core +1 more source
Unbiased translation proteomics upon cell stress
Molecular & Cellular Oncology, 2020 The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently
Kevin Klann, Christian Münch
doaj +1 more source
Regulation of the mTOR/S6K pathway by cellular energy [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling pathway integrates positive and negative signals that control cellular growth, metabolism and survival. mTOR exists in two different complexes, mTOR Complex1 and mTOR Complex2.
Kalender, Adem
core +1 more source
Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
Molecular & Cellular Oncology, 2020 We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET.
Alexia Hervieu, Stéphanie Kermorgant
doaj +1 more source
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]
, 2009 Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Richard-Bulteau, Hélène +58 more
core +1 more source