Results 11 to 20 of about 401,475 (303)
Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy [PDF]
ACS Pharmacology & Translational Science, 2022 As an important regulator of cell metabolism, proliferation, and survival, mTOR (mammalian target of rapamycin) signaling provides both a potential target for cancer treatment and a research tool for investigation of cell metabolism. One inhibitor for both mTORC1 and mTORC2 pathways, OSI-027, exhibited robust anticancer efficacy but induced side ...
Tianyi Wang +8 more
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médecine/sciences, 2013 > Les troubles cognitifs occupent une place centrale dans la schizophrenie. Parfois severes, ils apparaissent precocement au cours de l’evolution de la pathologie et ont des consequences fonctionnelles importantes, notamment sur l’integration sociale et professionnelle des patients.
Philippe Marin +2 more
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Deconvoluting mTOR biology [PDF]
Cell Cycle, 2012 In metazoans, TOR is an essential protein that functions as a master regulator of cellular growth and proliferation. Over the past decade, there has been an explosion of information about this critical master kinase, ranging from the composition of the TOR protein complex to its ability to act as an integrator of numerous extracellular signals ...
Weber, Jason D, Gutmann, David H
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The effect of eight weeks of high-intensity interval training on p-mTOR, T-mTOR and fibrosis of cardiac tissue and insulin resistance in diabetic male Wistar rats [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2023 Background and Purpose: The mechanistic target of rapamycin (mTOR) protein complex increases in response to resistance training with a histological approach and decreases in aerobic training with a metabolic approach.
Saeed Dabagh Nikookheslat +3 more
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Thioredoxin-1 maintains mechanistic target of rapamycin (mTOR) function during oxidative stress in cardiomyocytes [PDF]
, 2017 Thioredoxin 1 (Trx1) is a 12-kDa oxidoreductase that catalyzes thiol-disulfide exchange reactions to reduce proteins with disulfide bonds. As such, Trx1 helps protect the heart against stresses, such as ischemia and pressure overload.
Bhat, Santosh +16 more
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Expanding mTOR signaling [PDF]
Cell Research, 2007 The mammalian target of rapamycin (mTOR) has drawn much attention recently because of its essential role in cell growth control and its involvement in human tumorigenesis. Great endeavors have been made to elucidate the functions and regulation of mTOR in the past decade.
Qian, Yang, Kun-Liang, Guan
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Unbiased translation proteomics upon cell stress
Molecular & Cellular Oncology, 2020 The mammalian target of rapamycin and the integrated stress response are central cellular hubs regulating translation upon stress. The precise proteins and pathway specificity of translation targets of these pathways remained largely unclear. We recently
Kevin Klann, Christian Münch
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بیان ژنهای PTEN، CDK4 و mTOR و میزان تزاید سلولی در ردهی سلولی سرطان پستان (T47D) تحت تأثیر تیمار با عصارهی هستهی انگور [PDF]
مجله دانشکده پزشکی اصفهان, 2021 مقدمه: سرطان پستان شایعترین بدخیمی در زنان میباشد. Phosphatase and tensin homolog (PTEN) ژن سرکوبکنندهی تومور است که در سرطان پستان دچار کاهش بیان میگردد.
عاطفه مجیری +3 more
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Glia, 2017 AbstractMyelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination.
Gianluca Figlia +2 more
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Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
Molecular & Cellular Oncology, 2020 We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET.
Alexia Hervieu, Stéphanie Kermorgant
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