Results 11 to 20 of about 306,339 (298)
Differential expression of mTOR signalling components in drug resistance in ovarian cancer [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 The International Institute of Anticancer Research.Background/Aim: A limitation to successful cancer ...
Karteris, E +5 more
core +6 more sources
Elucidating the role of DEPTOR in Alzheimer's disease [PDF]
, 2014 This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E +3 more
core +7 more sources
Glia, 2017 AbstractMyelinating cells surround axons to accelerate the propagation of action potentials, to support axonal health, and to refine neural circuits. Myelination is metabolically demanding and, consistent with this notion, mTORC1—a signaling hub coordinating cell metabolism—has been implicated as a key signal for myelination.
Gianluca Figlia +2 more
openaire +4 more sources
The Oncologist, 2010 AbstractInhibitors of mammalian target of rapamycin (mTOR) have been approved for the treatment of renal cell carcinoma and appear to have a role in the treatment of other malignancies. The primary objective of this drug review is to provide pharmacokinetic and dynamic properties of the commonly used drugs everolimus and temsirolimus.
Heinz-Josef, Klümpen +3 more
openaire +2 more sources
Neuron, 2014 The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular signaling hub that, like the nervous system itself, integrates internal and external cues to elicit critical outputs including growth control, protein synthesis, gene expression, and metabolic balance.
Lipton, Jonathan O., Sahin, Mustafa
openaire +2 more sources
Optochemical Control of mTOR Signaling and mTOR-Dependent Autophagy [PDF]
ACS Pharmacology & Translational Science, 2022 As an important regulator of cell metabolism, proliferation, and survival, mTOR (mammalian target of rapamycin) signaling provides both a potential target for cancer treatment and a research tool for investigation of cell metabolism. One inhibitor for both mTORC1 and mTORC2 pathways, OSI-027, exhibited robust anticancer efficacy but induced side ...
Tianyi Wang +8 more
openaire +2 more sources
médecine/sciences, 2013 > Les troubles cognitifs occupent une place centrale dans la schizophrenie. Parfois severes, ils apparaissent precocement au cours de l’evolution de la pathologie et ont des consequences fonctionnelles importantes, notamment sur l’integration sociale et professionnelle des patients.
Philippe Marin +2 more
openaire +1 more source
Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]
, 2012 Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian +1 more
core +1 more source
Regulation of the mTOR/S6K pathway by cellular energy [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling pathway integrates positive and negative signals that control cellular growth, metabolism and survival. mTOR exists in two different complexes, mTOR Complex1 and mTOR Complex2.
Kalender, Adem
core +1 more source
Quantitative phosphoproteomics reveal that mTOR regulates cell growth and proliferation by phosphorylating a functionally diverse set of substrates [PDF]
, 2012 The atypical Ser/Thr kinase target of rapamycin (TOR) is a central controller of cell growth and proliferation. TOR forms two distinct multiprotein complexes, TORC1 and TORC2, which are structurally and functionally conserved from yeast to humans.
Robitaille, Aaron M.
core +1 more source