Results 41 to 50 of about 320,721 (362)

The role of mTOR complex 1 in skeletal muscle [PDF]

, 2012
An important factor in energy and nutrient pathways is the mammalian target of rapamycin complex 1 (mTORC1). The multiprotein complex, with the central component mTOR, regulates cell growth and survival.
Romanino, Klaas Emilio Antonius Anna
core   +1 more source

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits

Frontiers in Bioscience-Landmark, 2022
Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition,
Arthur J. Chu
doaj   +1 more source

Updates of mTOR Inhibitors [PDF]

Anti-Cancer Agents in Medicinal Chemistry, 2010
Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. mTOR signaling is often dysregulated in various human diseases and thus attracts great interest in developing drugs that target mTOR.
Hongyu, Zhou, Yan, Luo, Shile, Huang
openaire   +2 more sources

mTOR, Cancer and Transplantation [PDF]

American Journal of Transplantation, 2008
One of the most clinically important molecular signalling networks to emerge over the past decade is the mammalian target of rapamycin (mTOR) pathway. mTOR, the protein kinase at the core of this intricate and continually evolving pathway, controls cellular growth and behavior, impacting vital processes from immune reactivity to cancer progression.
Edward K, Geissler, Hans J, Schlitt, George, Thomas   +2 more
openaire   +2 more sources

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Stretton, Clare, Taylor, Peter M., Hundal, Harinder, Prescott, Alan; id_orcid, Hoffmann, Thorsten M., Ganley, Ian G.; id_orcid, Munson, Michael J.   +6 more
core   +1 more source

Cerebral ischemia reperfusion injury: from public health perspectives to mechanisms

Folia Neuropathologica, 2022
Cerebral ischemia/reperfusion injury has emerged as an intricate mechanism. However, identification of wide-ranging mechanisms which mechanistically regulate reperfusion injuries have significantly improved our understanding.
Gulnara Kapanova, Gulnara Tashenova, Aida Akhenbekova, Adem Tokpınar, Seher Yılmaz   +4 more
doaj   +1 more source

mTOR, autophagy, and reprogramming

Frontiers in Cell and Developmental Biology, 2014
Nuclear reprogramming to achieve induced-pluripotency by the Yamanaka factors (Takahashi and Yamanaka, 2006) is largely viewed as a consequence of a cascade of expression profile changes, along with alterations in epigenetic markings, which are primarily nuclear events.
openaire   +4 more sources

mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node

Orphanet Journal of Rare Diseases
Mechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates key cellular processes including cell growth, autophagy and metabolism.
Laura Mantoan Ritter, Nicholas M. P. Annear, Emma L. Baple, Leila Y. Ben-Chaabane, Istvan Bodi, Lauren Brosson, Jill E. Cadwgan, Bryn Coslett, Andrew H. Crosby, D. Mark Davies, Nicola Daykin, Stefanie Dedeurwaerdere, Christina Dühring Fenger, Elaine A. Dunlop, Frances V. Elmslie, Marie Girodengo, Sophie Hambleton, Anna C. Jansen, Simon R. Johnson, Kelly C. Kearley, John C. Kingswood, Liisi Laaniste, Katherine Lachlan, Andrew Latchford, Ralitsa R. Madsen, Sahar Mansour, Simeon R. Mihaylov, Louwai Muhammed, Claire Oliver, Tom Pepper, Lettie E. Rawlins, Ina Schim van der Loeff, Ata Siddiqui, Pooja Takhar, Katrina Tatton-Brown, Andrew R. Tee, Priyanka Tibarewal, Charlotte Tye, Sila K. Ultanir, Bart Vanhaesebroeck, Benjamin Zare, Deb K. Pal, Joseph M. Bateman   +42 more
doaj   +1 more source

Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction

Cells, 2019
Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang, Fengxia Yan, Zhongping Feng, Philip Lazarovici, Wenhua Zheng   +4 more
doaj   +1 more source