4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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mTOR, Cancer and Transplantation [PDF]
American Journal of Transplantation, 2008 One of the most clinically important molecular signalling networks to emerge over the past decade is the mammalian target of rapamycin (mTOR) pathway. mTOR, the protein kinase at the core of this intricate and continually evolving pathway, controls cellular growth and behavior, impacting vital processes from immune reactivity to cancer progression.
Edward K, Geissler +2 more
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Hypoxia-induced signaling in angiogenesis : role of mTOR, HIF and Angiotensin II [PDF]
, 2007 This thesis includes the work of four different projects I have been following during my time as a PhD student; (1) the characterization of mTOR-associated signaling and endothelial cell proliferation in response to hypoxia, and (2) identification of ...
Petrimpol, Marco Renato
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Expression of mTOR and downstream signalling components in the JEG-3 and BeWo human placental choriocarcinoma cell lines [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund.Emerging data suggest that nutritional status and body weight are related to reproductive function, and nutrient imbalances during pregnancy lead to changes in the ...
Karteris, E +6 more
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Caffeine affects the biological responses of human hematopoietic cells of myeloid lineage via downregulation of the mTOR pathway and xanthine oxidase activity [PDF]
, 2015 Correction of human myeloid cell function is crucial for the prevention of inflammatory and allergic reactions as well as leukaemia progression. Caffeine, a naturally occurring food component, is known to display anti-inflammatory effects which have ...
Sumbayev, Vadim V. +22 more
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Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Cells, 2019 Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang +4 more
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The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]
, 2007 Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Brand, Stephan +8 more
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mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node
Orphanet Journal of Rare DiseasesMechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates key cellular processes including cell growth, autophagy and metabolism.
Laura Mantoan Ritter +42 more
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Pharmaceutical Biology, 2019 Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro.
Keun-Hyeun Lee +6 more
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Control of muscle protein synthesis in response to exercise and amino acids
Journal of Physical Fitness and Sports Medicine, 2012 There is a general consensus that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. The intracellular signaling pathways through the mammalian target of rapamycin (mTOR),
Naoya Nakai +2 more
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