Results 41 to 50 of about 287,979 (313)
mTOR signaling in tumorigenesis [PDF]
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014 mTOR (the mechanistic target of rapamycin) is an atypical serine/threonine kinase involved in regulating major cellular functions including growth and proliferation. Deregulation of the mTOR signaling pathway is one of the most commonly observed pathological alterations in human cancers.
Kai, Xu, Pengda, Liu, Wenyi, Wei
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Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]
, 2005 Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
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IBS004735 activates Akt-mTOR-S6K axis. [PDF]
, 2020 (A) C2C12 cells were cultured in differentiation medium with DMSO or 10 μM IBS004735 for the indicated periods of time. The cell lysates were immunoblotted with the indicated antibodies.
Naoki Yamamoto (200072) +17 more
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4 open, 2019 The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
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mTOR regulation of autophagy [PDF]
FEBS Letters, 2010 Nutrient starvation induces autophagy in eukaryotic cells through inhibition of TOR (target of rapamycin), an evolutionarily‐conserved protein kinase. TOR, as a central regulator of cell growth, plays a key role at the interface of the pathways that coordinately regulate the balance between cell growth and autophagy in response to nutritional status ...
Jung, Chang Hwa +4 more
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The role of mTOR complex 1 in skeletal muscle [PDF]
, 2012 An important factor in energy and nutrient pathways is the mammalian target of rapamycin complex 1 (mTORC1). The multiprotein complex, with the central component mTOR, regulates cell growth and survival.
Romanino, Klaas Emilio Antonius Anna
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Updates of mTOR Inhibitors [PDF]
Anti-Cancer Agents in Medicinal Chemistry, 2010 Mammalian target of rapamycin (mTOR) is a central controller of cell growth, proliferation, metabolism and angiogenesis. mTOR signaling is often dysregulated in various human diseases and thus attracts great interest in developing drugs that target mTOR.
Hongyu, Zhou, Yan, Luo, Shile, Huang
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MTOR-siRNA eliminated the protein interaction of Rictor and mTOR protein and inhibited the phosphorylation of AKT. [PDF]
, 2016 (A) HLE B3 cells were treated with mTOR-siRNA, non-silencing siRNA or control and harvested after 24, 48 and 72 hours of transfection. The levels of mRNA were determined by quantitative real-time PCR.
Hongling Liu (687235) +5 more
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mTOR, Cancer and Transplantation [PDF]
American Journal of Transplantation, 2008 One of the most clinically important molecular signalling networks to emerge over the past decade is the mammalian target of rapamycin (mTOR) pathway. mTOR, the protein kinase at the core of this intricate and continually evolving pathway, controls cellular growth and behavior, impacting vital processes from immune reactivity to cancer progression.
Edward K, Geissler +2 more
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GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]
, 2015 The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Stretton, Clare +6 more
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