Results 61 to 70 of about 287,979 (313)

Placental DEPTOR as a stress sensor during pregnancy [PDF]

, 2011
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Karteris, E, Zachariades, E, Emmanouil Karteris, Goumenou, A, Yori Gidron, Gidron, Y, Anastasia Goumenou, Mparmpakas, D, Dionisis Mparmpakas, Elena Zachariades   +9 more
core   +1 more source

Combination of dual mTORC1/2 inhibition and immune-checkpoint blockade potentiates anti-tumour immunity

OncoImmunology, 2018
mTOR inhibition can promote or inhibit immune responses in a context dependent manner, but whether this will represent a net benefit or be contraindicated in the context of immunooncology therapies is less understood.
Sophie Langdon, Adina Hughes, Molly A. Taylor, Elizabeth A. Kuczynski, Deanna A. Mele, Oona Delpuech, Laura Jarvis, Anna Staniszewska, Sabina Cosulich, Larissa S. Carnevalli, Charles Sinclair   +10 more
doaj   +1 more source

Role of Ran GTPase in regulating milk protein synthesis signaling pathways in bovine mammary epithelial cells [PDF]

Tikrit Journal for Agricultural Sciences
RAN, A member of the small GTPase superfamily, is involved in various cellular signaling pathways. That regulates cell cycle progression and protein synthesis. This study aimed to investigate how Ran influences key signaling pathways associated with cell
Nagam Khudhair, THEFAF AHMED, Ahmed Ahmed   +2 more
doaj   +1 more source

Stimulation of mTORC2 by integrin αIIbβ3 is required for PI3Kβ-dependent activation of Akt but is dispensable for platelet spreading on fibrinogen

Platelets, 2020
Phosphatidylinositol 3 kinase (PI3K) is a major player in platelet activation and regulates thrombus formation and stabilization. The β isoform of PI3K is implicated in integrin αIIbβ3 outside-in signaling, is required for the phosphorylation of Akt, and
Mauro Torti, Daria Manganaro, Caterina Visconte, Marta Zarà, Jessica Canino, Mauro Vismara, Ilaria Canobbio, Gianni Francesco Guidetti   +7 more
doaj   +1 more source

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

Molecules, 2020
Alzheimer’s disease (AD) is one of the utmost chronic neurodegenerative disorders, which is characterized from a neuropathological point of view by the aggregates of amyloid beta (Aβ) peptides that are deposited as senile plaques and tau ...
Md. Sahab Uddin, Md. Tanvir Kabir, Kamal Niaz, Philippe Jeandet, Christophe Clément, Bijo Mathew, Abdur Rauf, Kannan R.R. Rengasamy, Eduardo Sobarzo-Sánchez, Ghulam Md Ashraf, Lotfi Aleya   +10 more
doaj   +1 more source

Cerebral ischemia reperfusion injury: from public health perspectives to mechanisms

Folia Neuropathologica, 2022
Cerebral ischemia/reperfusion injury has emerged as an intricate mechanism. However, identification of wide-ranging mechanisms which mechanistically regulate reperfusion injuries have significantly improved our understanding.
Gulnara Kapanova, Gulnara Tashenova, Aida Akhenbekova, Adem Tokpınar, Seher Yılmaz   +4 more
doaj   +1 more source

Dissecting the role of mTOR: Lessons from mTOR inhibitors

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010
Recent years have observed significant advances in our understanding of how the serine/threonine kinase target of rapamycin (TOR) controls key cellular processes such as cell survival, growth and proliferation. Consistent with its role in cell proliferation, the mTOR pathway is frequently hyperactivated in a number of human malignancies and is thus ...
Dowling, Ryan J.O., Topisirovic, Ivan, Fonseca, Bruno D., Sonenberg, Nahum   +3 more
openaire   +2 more sources

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Elucidating the role of DEPTOR in Alzheimer's disease [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E, Zachariades, E, Rogers-Broadway, K-R, Davies, J, Davies, Julie   +4 more
core   +1 more source

mTOR-Mediated Autophagy Regulates Fumonisin B₁‑Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro [PDF]

, 2022
Fumonisin B1 (FB1) is a fungal metabolite, which has an incremental detection rate in grains and feed worldwide. The nucleotide-binding oligomerization domain-like pyrin domain containing protein 3 (NLRP3) inflammasome is a critical element in ...
Shuiping Liu (72386), Lei Ge (520445), Xinru Mao (10969722), Lili Hou (30852), Kehe Huang (172082), Xingxiang Chen (172064), Heng Du (278498), Dongmei Yue (1989394)   +7 more
core   +1 more source