Results 51 to 60 of about 287,979 (313)
Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction
Cells, 2019 Dietary restriction (DR), which is defined as a reduction of particular or total nutrient intake without causing malnutrition, has been proved to be a robust way to extend both lifespan and health-span in various species from yeast to mammal.
Yizhou Jiang +4 more
doaj +1 more source
mTOR, autophagy, and reprogramming
Frontiers in Cell and Developmental Biology, 2014 Nuclear reprogramming to achieve induced-pluripotency by the Yamanaka factors (Takahashi and Yamanaka, 2006) is largely viewed as a consequence of a cascade of expression profile changes, along with alterations in epigenetic markings, which are primarily nuclear events.
openaire +4 more sources
mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node
Orphanet Journal of Rare DiseasesMechanistic target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates key cellular processes including cell growth, autophagy and metabolism.
Laura Mantoan Ritter +42 more
doaj +1 more source
Pharmaceutical Biology, 2019 Context: Eclipta prostrata L. (Asteraceae) (EP) has been widely used for the treatment of skin disease in Asian traditional medicine. Objective: This study investigates the potency of EP in promoting hair growth in vivo and in vitro.
Keun-Hyeun Lee +6 more
doaj +1 more source
Control of muscle protein synthesis in response to exercise and amino acids
Journal of Physical Fitness and Sports Medicine, 2012 There is a general consensus that resistance exercise and nutrition (especially amino acids) are the most effective interventions for maintaining skeletal muscle mass. The intracellular signaling pathways through the mammalian target of rapamycin (mTOR),
Naoya Nakai +2 more
doaj +1 more source
Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits
Frontiers in Bioscience-Landmark, 2022 Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition,
Arthur J. Chu
doaj +1 more source
Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas
Pediatric Blood &Cancer, EarlyView.ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall +2 more
wiley +1 more source
mTOR complex 2 - akt signaling is physically and functionally at mam [PDF]
, 2012 The target of rapamycin (TOR) is a conserved protein kinase and a central controller of growth. TOR can be part of two structurally and functionally distinct complexes, termed TOR complex 1 and TOR complex 2.
Betz, Charles
core +1 more source
Roles of mTOR and p-mTOR in Gastrointestinal Stromal Tumors
Asian Pacific Journal of Cancer Prevention, 2013 This study aimed to examine the relationship between expression of mammal target of rapamycin (mTOR) and phosphorylation of mTOR (p-mTOR) protein in the PI3K/Akt/mTOR signaling pathways in gastrointestinal stromal tumors and relatiuonships with clinical factors.Immunohistochemistry was used to detect the expression of the associated proteins mTOR, p ...
Jun-Chuan, Li +6 more
openaire +3 more sources
The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo +5 more
wiley +1 more source