Results 71 to 80 of about 287,979 (313)

Response of metastatic mouse invasive lobular carcinoma to mTOR inhibition is partly mediated by the adaptive immune system

OncoImmunology, 2020
Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy.
Sjoerd Klarenbeek, Chris W. Doornebal, Sjors M. Kas, Nicola Bonzanni, Jinhyuk Bhin, Tanya M. Braumuller, Ingrid van der Heijden, Mark Opdam, Philip C. Schouten, Kelly Kersten, Roebi de Bruijn, Daniel Zingg, Julia Yemelyanenko, Lodewyk F.A. Wessels, Karin E. de Visser, Jos Jonkers   +15 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

mTOR-iMCD-Blood_Article_Data_Repository [PDF]

, 2020
This permanent Zenodo entry corresponds to the original data used for the manuscript: "Increased mTOR activation in idiopathic multicentric Castleman disease" accepted for publication by Blood.
Daniel J. Arenas (2395705), David Fajgenbaum (6946268), Daniel J. Arenas, David Fajgenbaum   +3 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Interferon-alpha-induced mTOR activation is an anti-hepatitis C virus signal via the phosphatidylinositol 3-kinase-Akt-independent pathway. [PDF]

, 2009
OBJECT: The interferon-induced Jak-STAT signal alone is not sufficient to explain all the biological effects of IFN. The PI3-K pathways have emerged as a critical additional component of IFN-induced signaling.
Ikeda, Masanori, Eguchi, Katsumi, Yamasaki, Hironori, Nakao, Kazuhiko, Ichikawa, Tatsuki, Fujimito, Masumi, Takeshita, Shigeyuki, Miuma, Satoshi, Akiyama, Motohisa, Matsumoto, Azusa, Shibata, Hidetaka, Kato, Nobuyuki, Miyaaki, Hisamitsu, Hirano, Kumi, Ozawa, Eisuke   +14 more
core   +1 more source

Combined physical activity in the prevention of cardiovascular diseases: from physiological to molecular adaptation mechanisms

Клиническая практика
Physical activity is recognized as the most important non-medicinal tool for the prevention of cardiovascular diseases, however, the highest efficiency is demonstrated by the programs combining various types of physical load.
Abduragim R. Magomedov, Polina V. Rykova, Bogdan A. Anokhin, Arthur Kh. Melikian, Minas A. Agaronyan, Arina G. Sarkisyan, Ekaterina S. Shimko, Ayshat Yu. Yusupova, Elvina R. Irgalieva, Eset M. Bokova, Rashid S. Mokaev, Darya V. Leonova, Adil Sh. Kendzhametov   +12 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Differential expression of mTOR signalling components in drug resistance in ovarian cancer [PDF]

, 2010
This article has been made available through the Brunel Open Access Publishing Fund and is available from the specified link - Copyright @ 2010 The International Institute of Anticancer Research.Background/Aim: A limitation to successful cancer ...
Karteris, E, Foster, H, Goumenou, A, Pados, G, Harvey, AJ, Coley, HM   +5 more
core  

Polyphenol-rich extract from Wisteria floribunda (Willd.) DC. flowers promotes osteoblast differentiation and bone formation by modulating the mTOR pathway

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the osteogenic effects of polyphenol-rich extracts from Wisteria floribunda (Willd.) DC. (W. floribunda) flowers and elucidate the underlying mechanisms. Methods: Polyphenolic compounds of W.
Jayasingha Arachchige Chathuranga Chanaka Jayasingha, Kyoung Tae Lee, Cheng-Yun Jin, Yung Hyun Choi, Chang Soo Lee, Min-Jeong Jung, Gi-Young Kim   +6 more
doaj   +1 more source

The Difference in Expression of Autophagy-Related Proteins in Lesional and Perilesional Skin in Adult Patients with Active and Stable Generalized Vitiligo—A Cross-Sectional Pilot Study

Indian Journal of Dermatology, 2021
Background: Autophagy plays an important role in maintaining intracellular homeostasis and is essential for cell survival and cell death. Dysfunction of autophagy has been described in many autoimmune diseases but data on vitiligo are scarce.
Haiyan Yu, Xiaoxia Lin, Yaoyao Huang, Hao Cheng, Oliver Seifert   +4 more
doaj   +1 more source