Results 91 to 100 of about 320,721 (362)
, 2016 (A) HLE B3 cells were treated with mTOR-siRNA, non-silencing siRNA or control and harvested after 24, 48 and 72 hours of transfection. The levels of mRNA were determined by quantitative real-time PCR.
Hongling Liu (687235) +5 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Role of Ran GTPase in regulating milk protein synthesis signaling pathways in bovine mammary epithelial cells [PDF]
Tikrit Journal for Agricultural SciencesRAN, A member of the small GTPase superfamily, is involved in various cellular signaling pathways. That regulates cell cycle progression and protein synthesis. This study aimed to investigate how Ran influences key signaling pathways associated with cell
Nagam Khudhair +2 more
doaj +1 more source
mTOR inhibitors: An overview [PDF]
Liver Transplantation, 2001 Inhibitors of the mammalian target of rapamycin are a new class of immunosuppressants. In contrast to other macrolides, such as tacrolimus and cyclosporine A, they do not inhibit calcineurin and thus signal I of T-cell activation.
P, Neuhaus, J, Klupp, J M, Langrehr
openaire +2 more sources
A conditional mouse model for the characterization of mTORC1 function in muscle and brain [PDF]
, 2010 The Ser/Thr kinase mammalian target of rapamycin (mTOR) regulates cell growth in response to extracellular stimulation with growth factors and to intracellular factors that sense the nutritional and the energy state of the cell.
Cloëtta, Dimitri Yves Reto
core +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
mTOR Pathway and mTOR Inhibitors in Cancer Therapy [PDF]
British Journal of Clinical Pharmacology, 2011 The latest in the series of monographs Cancer Drug Discovery and Development is mTOR Pathway and mTOR Inhibitors in Cancer Therapy. Rapamycin was first employed as an antifungal agent in humans and named for the Polynesians (Papa Nui) who inhabited Easter Island, where it was isolated from the bacteria Streptomyces hygroscopidcus.
openaire +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
G3: Genes, Genomes, Genetics, 2020 Several techniques have been developed to study specific gene function in loss-of-function situations. In Drosophila melanogaster, RNAi and the generation of mutant clones are widely used.
Pablo Sanchez Bosch +2 more
doaj +1 more source