Results 111 to 120 of about 306,339 (298)

IBS004735 activates Akt-mTOR-S6K axis.

, 2020
(A) C2C12 cells were cultured in differentiation medium with DMSO or 10 μM IBS004735 for the indicated periods of time. The cell lysates were immunoblotted with the indicated antibodies.
Naoki Yamamoto (200072), Manami Kodaka (8690217), Takuya Oyaizu (8690235), Kentaro Nakagawa (8690229), Yutaka Hata (405741), Hiroshi Nishina (334827), Junichi Maruyama (6065771), Kyoko Arimoto-Matsuzaki (761824), Zeyu Yang (8690226), Fengju Mao (8690220), Chihiro Akazawa (751401), Kana Ishii (8690232), Shigeru Ito (343220), Xiaoyin Xu (773234), Hiroyuki Kagechika (838715), Nozomi Tsuemoto (8690238), Masami Kitamura (8690223), Mari Ishigami-Yuasa (838714)   +17 more
core   +1 more source

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Tuberous sclerosis complex: a case report [PDF]

Romanian Journal of Pediatrics
Background. Tuberous sclerosis complex (TSC) is a rare genetic disorder diagnosed in 6000-10000 children annually, marked by hamartomas in various organs due to hyperactivity of the mTOR pathway. Case report.
Hanna Sebesi, Réka Borka-Balás, Micheu Cristian Ion   +2 more
doaj   +1 more source

Elastomeric 3D‐Printed Microenvironments Enable Nanonewton Force Measurements in Healthy and Diseased Human Pluripotent Stem Cell‐Derived Neuroepithelial Cells

Advanced Materials, EarlyView.
We present elastomeric three‐dimensional (3D) microstructures fabricated via two‐photon polymerization (2PP) and post‐processed through wet etching, for quantifying nanonewton (nN)‐scale forces applied by healthy and diseased neural cells. The mechanically characterized free‐standing beam architectures enable measurement of traction forces of ...
Pieter F. J. van Altena, Lucia Castillo Ransanz, Ruben H. Guis, Giulia Bergamaschi, Nanne J. Paauw, Urs Staufer, Vivi M. Heine, Angelo Accardo   +7 more
wiley   +1 more source

Gene expression of MTOR, MURF-1 and MAFBX in wistar rats supplemented with whey proteins

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2023
To verify the effect of supplementation of different doses of Whey Proteins for 12 weeks on the gene expression of MTOR, MURF-1, MAFBX and on the alteration of the cellular diameter of the gastrocnemius muscle. Sample: 38 Wistar rats and supplemented for
Marcos Roberto Campos de Macêdo, Antonio Coppi Navarro, Raphael Furtado Marques, Melaine Mont´Alverne Lawall Silva, Flavia Castello Branco Vidal, Alanna Joselle Santiago Silva, Carlos Eduardo Neves Amorim, Francisco Navarro   +7 more
doaj  

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

A conditional mouse model for the characterization of mTORC1 function in muscle and brain [PDF]

, 2010
The Ser/Thr kinase mammalian target of rapamycin (mTOR) regulates cell growth in response to extracellular stimulation with growth factors and to intracellular factors that sense the nutritional and the energy state of the cell.
Cloëtta, Dimitri Yves Reto
core   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Influence of oxidative stress on the activity of mTOR kinase in CD4+T lymphocytes in autoimmune thyroiditis

Медицинская иммунология
Currentstudies of autoimmunityprocesses areaddressing specific processes involving mitochondria, i.e., altered intracellular signaling including the generation of ROS and release of proteins from mitochondria to the cytoplasm, thus activating apoptosis ...
A. V. Burtseva, A. N. Tikhonova, Z. A. Afanasyeva, Z. I. Abramova   +3 more
doaj   +1 more source