Results 121 to 130 of about 320,721 (362)

Investigation of the effects of different mTOR inhibitors on protein synthesis

, 2011
The mammalian target of rapamycin (mTOR), which controls diverse cellular processes, is regulated by the integration of many signals. Rapamycin strongly inhibits the proliferation of many cancer cell lines and there is a high level of interest in its ...
Huo, Yilin
core  

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Gene expression of MTOR, MURF-1 and MAFBX in wistar rats supplemented with whey proteins

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2023
To verify the effect of supplementation of different doses of Whey Proteins for 12 weeks on the gene expression of MTOR, MURF-1, MAFBX and on the alteration of the cellular diameter of the gastrocnemius muscle. Sample: 38 Wistar rats and supplemented for
Marcos Roberto Campos de Macêdo, Antonio Coppi Navarro, Raphael Furtado Marques, Melaine Mont´Alverne Lawall Silva, Flavia Castello Branco Vidal, Alanna Joselle Santiago Silva, Carlos Eduardo Neves Amorim, Francisco Navarro   +7 more
doaj  

Старение стволовых клеток человека в контексте mTOR сигналинга [PDF]

, 2017
Для предотвращения преждевременного старения стволовых клеток, вызванного окислительным стрессом, необходимо блокировать активность сигнальных путей, участвующих в реализации программы старения.
Griukova Anastasiia, Грюкова Анастасия Александровна   +1 more
core  

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Tobacco Mosaic Viral Nanoparticle Inhibited Osteoclastogenesis Through Inhibiting mTOR/AKT Signaling

International Journal of Nanomedicine, 2020
Zhongshu Shan,1,2,* Hongtao Bi,3,* Angxiu Suonan,2 Yong Gu,1 Huan Zhou,4 Kun Xi,1 Rui Xiong,5 Hua Chen,2 Liang Chen1 1Department of Orthopedic Surgery, The 1st Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China ...
Shan Z, Bi H, Suonan A, Gu Y, Zhou H, Xi K, Xiong R, Chen H, Chen L   +8 more
doaj  

mTOR signaling in disease

Current Opinion in Cell Biology, 2011
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in
Dazert, E., Hall, M. N.
openaire   +5 more sources

mTOR Pathway in Renal Cell Carcinoma

, 2016
The therapeutic approach of patients with metastatic renal cell carcinoma (mRCC) has been completely changed by the advent of agents targeting the vascular endothelial growth factor receptor and mammalian target of rapamycin (mTOR) pathway.
Santoni M., Massari F., Matteo Santoni, Francesco Massari   +3 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Photodynamic Therapy Enhanced the Antitumor Effects of Berberine on HeLa Cells

Open Chemistry, 2019
In this study we investigated the antineoplastic effects of Berberine (BBR)-mediated photodynamic therapy (PDT) on HeLa cells and its related mechanisms.
Liu Han-Qing, An Ya-Wen, Hu A-Zhen, Li Ming-Hua, Cui Guang-Hui   +4 more
doaj   +1 more source