Results 121 to 130 of about 287,979 (313)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Старение стволовых клеток человека в контексте mTOR сигналинга [PDF]

, 2017
Для предотвращения преждевременного старения стволовых клеток, вызванного окислительным стрессом, необходимо блокировать активность сигнальных путей, участвующих в реализации программы старения.
Griukova Anastasiia, Грюкова Анастасия Александровна   +1 more
core  

Tobacco Mosaic Viral Nanoparticle Inhibited Osteoclastogenesis Through Inhibiting mTOR/AKT Signaling

International Journal of Nanomedicine, 2020
Zhongshu Shan,1,2,* Hongtao Bi,3,* Angxiu Suonan,2 Yong Gu,1 Huan Zhou,4 Kun Xi,1 Rui Xiong,5 Hua Chen,2 Liang Chen1 1Department of Orthopedic Surgery, The 1st Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China ...
Shan Z, Bi H, Suonan A, Gu Y, Zhou H, Xi K, Xiong R, Chen H, Chen L   +8 more
doaj  

mTOR signaling in disease

Current Opinion in Cell Biology, 2011
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in
Dazert, E., Hall, M. N.
openaire   +5 more sources

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

AMPK-mTOR-P70S6K signaling cascades are involved in the regulation of CB2R on autophagy both in intro and in vivo. [PDF]

, 2016
Peritoneal macrophages from WT and CB2R KO mice were isolated and primed with LPS (10 ng/ml) for 1 h, and then were stimulated with 3% DSS. Colon tissues were isolated from mice at day 8 after DSS-induced colitis.
Zhe-Qi Xu (3110766), Xiong-Wen Chen (3110760), Chong Liu (450204), Bin-Ze Han (3110757), Wei Wei (21173), Ping Ke (3110763), Ding-Feng Su (685862), Bo-Zong Shao (3110769)   +7 more
core   +1 more source

Tuberous sclerosis complex: a case report [PDF]

Romanian Journal of Pediatrics
Background. Tuberous sclerosis complex (TSC) is a rare genetic disorder diagnosed in 6000-10000 children annually, marked by hamartomas in various organs due to hyperactivity of the mTOR pathway. Case report.
Hanna Sebesi, Réka Borka-Balás, Micheu Cristian Ion   +2 more
doaj   +1 more source

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

Distinct and common functions of mTORC1 and mTORC2 in Purkinje cells [PDF]

, 2015
In mammalian cells, the serine/threonine protein kinase mTOR (mammalian target of rapamycin) is present in two complexes, called mTORC1 and mTORC2. While several of the components are common to both complexes, raptor and rictor are only associated with ...
Angliker, Nico
core   +1 more source

Gene expression of MTOR, MURF-1 and MAFBX in wistar rats supplemented with whey proteins

Revista Brasileira de Obesidade, Nutrição e Emagrecimento, 2023
To verify the effect of supplementation of different doses of Whey Proteins for 12 weeks on the gene expression of MTOR, MURF-1, MAFBX and on the alteration of the cellular diameter of the gastrocnemius muscle. Sample: 38 Wistar rats and supplemented for
Marcos Roberto Campos de Macêdo, Antonio Coppi Navarro, Raphael Furtado Marques, Melaine Mont´Alverne Lawall Silva, Flavia Castello Branco Vidal, Alanna Joselle Santiago Silva, Carlos Eduardo Neves Amorim, Francisco Navarro   +7 more
doaj