Results 131 to 140 of about 287,979 (313)

Molecular neurobiology of mTOR

Neuroscience, 2017
Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that controls several important aspects of mammalian cell function. mTOR activity is modulated by various intra- and extracellular factors; in turn, mTOR changes rates of translation, transcription, protein degradation, cell signaling, metabolism, and cytoskeleton dynamics ...
Switon, Katarzyna, Kotulska, Katarzyna, Janusz-Kaminska, Aleksandra, Zmorzynska, Justyna, Jaworski, Jacek   +4 more
openaire   +2 more sources

An Ion‐Based Strategy Toward Synergistic Surface Functionalization Combining the Osteogenic Properties and NIR‐Mediated Antibacterial Activity of PEEK

Advanced Materials, EarlyView.
A multifunctional bioactive PEEK‐based implant (Mn@p/MBG‐SPEEK) is engineered to combat implant‐associated infections while promoting osteogenesis. The hybrid surface activates PI3K/Akt/mTOR and AP‐1 signaling pathways for osteogenic differentiation, while Mn coordination induces electronic coupling that narrows the HOMO‐LUMO energy gap and enhances ...
Zhiyan Xu, Ondřej Adam, Marek Doubrava, Ana M. Beltrán, Ivo Dlouhý, Xin Liu, Baiyan Sui, Aldo R. Boccaccini   +7 more
wiley   +1 more source

MTOR-Driven Metabolic Reprogramming Regulates Legionella pneumophila Intracellular Niche Homeostasis. [PDF]

, 2016
Vacuolar bacterial pathogens are sheltered within unique membrane-bound organelles that expand over time to support bacterial replication. These compartments sequester bacterial molecules away from host cytosolic immunosurveillance pathways that induce ...
Stanimir S Ivanov, Stanimir S. Ivanov (3394922), Ana-Maria Dragoi, Craig R Roy, Camille F Abshire, Camille F. Abshire (141267), Craig R. Roy (103064), Ana-Maria Dragoi (662825)   +7 more
core   +1 more source

Targeting glutaminase and mTOR

Oncotarget, 2015
Comprehensive genomic and proteomic analyses demonstrate that there is nearly universal activation of the PI3K pathway in glioblastoma (GBM) patients [1]. Persistent PI3K signaling promotes GBM formation and tumor progression in genetic mouse models, establishing PI3K and its effecter mTOR as compelling molecular targets.
Kazuhiro, Tanaka, Takashi, Sasayama, Eiji, Kohmura   +2 more
openaire   +2 more sources

Reprogramming the Immunosuppressive Microenvironment in Triple‐Negative Breast Cancer via FAP‐Targeted Nanoprobes for Multimodal Imaging and Photothermal Therapy

Advanced Materials, EarlyView.
Targeting cancer‐associated fibroblasts (CAFs) with fibroblast activation protein (FAP)‐directed nanoprobes for multimodal imaging and photothermal remodeling of the immunosuppressive microenvironment to enhance immunotherapy in triple‐negative breast cancer (TNBC).
Ling Zhan, Yanhong Chen, Jingjing Hu, Chunting Wang, Huanhuan Liu, Defan Yao, Dengbin Wang   +6 more
wiley   +1 more source

Zastosowanie inhibitorów mTOR w wybranych schorzeniach dermatologicznych [PDF]

, 2011
Sirolimus, inaczej rapamycyna, i ewerolimus to nowe leki należące dotzw. inhibitorów mTOR, które znalazły zastosowanie głównie w transplantologiijako leki immunosupresyjne.
Alicja Dębska-Ślizień, Beata Imko-Walczuk, Bolesław Rutkowski, Karolina Osiecka, Sławomir Lizakowski   +4 more
core  

PPAR gamma/mTOR signalling: striking the right balance in cartilage homeostasis [PDF]

, 2015
This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work ...
Sherwood, Joanna; id_orcid, Dell'Accio, F, Sherwood, J, Dell'Accio, Francesco   +3 more
core   +1 more source

Photodynamic Therapy Enhanced the Antitumor Effects of Berberine on HeLa Cells

Open Chemistry, 2019
In this study we investigated the antineoplastic effects of Berberine (BBR)-mediated photodynamic therapy (PDT) on HeLa cells and its related mechanisms.
Liu Han-Qing, An Ya-Wen, Hu A-Zhen, Li Ming-Hua, Cui Guang-Hui   +4 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Identificação de biomarcadores terapêuticos em melanoma [PDF]

, 2011
Mestrado em Biomedicina MolecularO melanoma deriva da transformação maligna de melanócitos e é frequentemente encontrado na pele e na região ocular. A identificação de marcadores moleculares que inequivocamente indiquem a agressividade do tumor ou que
Tavares, Sandra Raquel de Oliveira
core   +1 more source