Results 131 to 140 of about 320,721 (362)
Distinct and common functions of mTORC1 and mTORC2 in Purkinje cells [PDF]
, 2015 In mammalian cells, the serine/threonine protein kinase mTOR (mammalian target of rapamycin) is present in two complexes, called mTORC1 and mTORC2. While several of the components are common to both complexes, raptor and rictor are only associated with ...
Angliker, Nico
core +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source
Molecular neurobiology of mTOR
Neuroscience, 2017 Mammalian/mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that controls several important aspects of mammalian cell function. mTOR activity is modulated by various intra- and extracellular factors; in turn, mTOR changes rates of translation, transcription, protein degradation, cell signaling, metabolism, and cytoskeleton dynamics ...
Switon, Katarzyna +4 more
openaire +2 more sources
NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks
Advanced Science, EarlyView.This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang +10 more
wiley +1 more source
C-C motif chemokine receptor 1 (CCR1) is a target of the EGF-AKT-mTOR-STAT3 signaling axis in breast cancer cells [PDF]
, 2017 Soon Young Shin +7 more
openalex +1 more source
Targeting glutaminase and mTOR
Oncotarget, 2015 Comprehensive genomic and proteomic analyses demonstrate that there is nearly universal activation of the PI3K pathway in glioblastoma (GBM) patients [1]. Persistent PI3K signaling promotes GBM formation and tumor progression in genetic mouse models, establishing PI3K and its effecter mTOR as compelling molecular targets.
Kazuhiro, Tanaka +2 more
openaire +2 more sources
Proposed models of the miR-451-AMPK-mTOR-cell cycle signaling pathway.
, 2018 (A) Proposed role of miR-451 in the regulation of LKB1/AMPK-mTOR signaling in response to high and low glucose levels. miR-451 levels determine glioma cell migration or proliferation in response to glucose (triangle on the left) via the AMPK-mTOR network
Hyeongi Kim (687050) +7 more
core +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Review for "CHML is an NRF2 target gene that regulates mTOR function"
, 2021 openalex +1 more source