Results 101 to 110 of about 320,721 (362)

Placental DEPTOR as a stress sensor during pregnancy

, 2011
The author(s) has paid for this article to be freely available under the terms of the Creative Commons Attribution Non-Commercial Licence (http://creativecommons.org/licenses/by-nc/2.5/) which permits unrestricted non-commercial use, distribution and ...
Karteris, E, Zachariades, E, Emmanouil Karteris, Goumenou, A, Yori Gidron, Gidron, Y, Anastasia Goumenou, Mparmpakas, D, Dionisis Mparmpakas, Elena Zachariades   +9 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

New insights into the "in vivo" and "in vitro" functions of mammalian TOR complex 2 [PDF]

, 2010
Target of rapamycin (TOR) is the main controller of cell growth and metabolism in response to nutrients, growth factors and the cellular energy status. TOR is a serine/threonine kinase conserved from yeast to mammals and is found in two functionally and
Cybulski, Nadine
core   +1 more source

mTOR-Mediated Autophagy Regulates Fumonisin B₁‑Induced Intestinal Inflammation via Pyroptosis In Vivo and In Vitro

, 2022
Fumonisin B1 (FB1) is a fungal metabolite, which has an incremental detection rate in grains and feed worldwide. The nucleotide-binding oligomerization domain-like pyrin domain containing protein 3 (NLRP3) inflammasome is a critical element in ...
Shuiping Liu (72386), Lei Ge (520445), Xinru Mao (10969722), Lili Hou (30852), Kehe Huang (172082), Xingxiang Chen (172064), Heng Du (278498), Dongmei Yue (1989394)   +7 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Supplementary Figure 7 from Akt Inhibitors MK-2206 and Nelfinavir Overcome mTOR Inhibitor Resistance in Diffuse Large B-cell Lymphoma [PDF]

, 2023
Adam M. Petrich, Violetta V. Leshchenko, Pei-Yu Kuo, Bing Xia, Venu K. Thirukonda, Netha Ulahannan, Shanisha Gordon, Melissa Fazzari, B. Hilda Ye, Joseph A. Sparano, Samir Parekh   +10 more
openalex   +1 more source

mTOR-iMCD-Blood_Article_Data_Repository

, 2020
This permanent Zenodo entry corresponds to the original data used for the manuscript: "Increased mTOR activation in idiopathic multicentric Castleman disease" accepted for publication by Blood.
Daniel J. Arenas (2395705), David Fajgenbaum (6946268), Daniel J. Arenas, David Fajgenbaum   +3 more
core   +1 more source

Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells [PDF]

, 2009
Background Treatment options for metastatic renal cell carcinoma (RCC) are limited due to resistance to chemo- and radiotherapy. The development of small-molecule multikinase inhibitors have now opened novel treatment options.
Natsheh, Iyad Y. M., Eva Juengel, Mickuckyte, Ausra, Hudak, Lukasz, Jones, Jon, Roman A Blaheta, Lukasz Hudak, Jüngel, Eva, Dietger Jonas, Blaheta, Roman A., Johanna Engler, Iyad Natsheh, Ausra Mickuckyte, Jonas, Dietger, Jon Jones, Engler, Johanna   +15 more
core   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Supplementary Data from The Efficacy of the Novel Dual PI3-Kinase/mTOR Inhibitor NVP-BEZ235 Compared with Rapamycin in Renal Cell Carcinoma [PDF]

, 2023
Daniel C. Cho, Matthew B. Cohen, David J. Panka, Michael J. Collins, Musie Ghebremichael, Michael B. Atkins, Sabina Signoretti, James W. Mier   +7 more
openalex   +1 more source