Results 11 to 20 of about 428,204 (309)

PI3K signalling [PDF]

, 2015
The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells.
Okkenhaug, Klaus, Turner, Martin, Gold, Michael R.   +2 more
openaire   +4 more sources

Targeting PI3K in neuroblastoma

Journal of Cancer Research and Clinical Oncology, 2010
This work employs pharmacological targeting of phosphoinositide 3-kinases (PI3K) in selected neuroblastoma (NB) tumors with the inhibitor AS605240, which has been shown to express low toxicity and relative specificity for the PI3K species γ.The expression pattern of PI3K isoforms in 7 NB cell lines and 14 tumor patient samples was determined by Western
Spitzenberg, Volker, König, Christian, Ulm, Susanne, Marone, Romina, Röpke, Luise, Müller, Jörg P., Grün, Michael, Bauer, Reinhard, Rubio, Ignacio, Wymann, Matthias Paul, Voigt, Astrid, Wetzker, Reinhard   +11 more
openaire   +4 more sources

The Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma [PDF]

Biologics: Targets & Therapy
Bangguo Song,1 Jihong Hu,2,3 Shupeng Chen,4 Yang Zhang5,6 1School of Clinical Chinese Medicine, Gansu University of Traditional Chinese Medicine, Gansu, People’s Republic of China; 2Teaching Experimental Training Center, Gansu University of Traditional ...
Song B, Hu J, Chen S, Zhang Y
doaj   +1 more source

PI3K Pathway in NSCLC [PDF]

Frontiers in Oncology, 2012
The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3'-hydroxyl group of phosphatidylinositol and phosphoinositides. PI3K regulate signaling pathways for neoplasia, including cell proliferation, adhesion, survival, and motility.
Martinez-Martí, Alex, Felip, Enriqueta
openaire   +3 more sources

Evidence for a PI3-kinase independent pathway in the regulation of Rap1b activation downstream of the P2Y12 receptor in platelets

Platelets, 2022
Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively.
Carol Dangelmaier, Satya P Kunapuli
doaj   +1 more source

Cardiac PI3K p110α attenuation delays aging and extends lifespan

Cell Stress, 2022
Phosphoinositide 3-kinase (PI3K) is a key component of the insulin signaling pathway that controls cellular metabolism and growth. Loss-of-function mutations in PI3K signaling and other downstream effectors of the insulin signaling pathway extend the ...
Mahmoud Abdellatif, Tobias Eisenberg, Alexander Martin Heberle, Kathrin Thedieck, Guido Kroemer, Simon Sedej   +5 more
doaj   +1 more source

Influenza A viruses and PI3K signalling [PDF]

, 2008
The influenza A virus non-structural (NS1) protein is multifunctional, and during virus-infection NS1 interacts with several factors in order to manipulate host-cell processes.
Hale, Benjamin G.
core   +2 more sources

Fresh autologous blood transfusion reverses erythrocytes damage by reducing oxidative stress via promoting mitochondrial metabolism and M2 macrophages polarization

Archives of Medical Science, 2022
Introduction Systemic inflammatory and immunosuppressive incidents constitute a significant hallmark of the adverse effects of RBC transfusion on red blood cells. These adverse side effects are seemingly associated with old blood transfusions; therefore,
Jia-Ming Xu, Lai-Wei You, Xiao-Fang Zhou, Yu Bai, Yong Cheng, Ying-Hui Cui, Xiao-Fei Chen, Jian-Rong Guo   +7 more
doaj   +1 more source

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia [PDF]

, 2013
Purpose: Aberrant PI3K/AKT/mTOR signaling has been linked to oncogenesis and therapy resistance in various malignancies including leukemias. In Philadelphia chromosome (Ph) positive leukemias, activation of PI3K by dysregulated BCR-ABL tyrosine kinase ...
Oliver G Ottmann, Martin Ruthardt, Oliver G. Ottmann, Oliver G. Ottmann (485229), Falkenburg, J.H.F., Marcus Liebermann (485228), Bart A. Nijmeijer (485227), Pfeifer, Heike, Falkenburg, J. H. Frederik, J. H. Frederik Falkenburg, Ruthardt, Martin, Tamara Tesanovic, Tesanovic, Tamara, Bart A Nijmeijer, Heike Pfeifer, Ottmann, Oliver G., Susanne Badura (485223), Sylvia Wystub, Sylvia Wystub (485226), Liebermann, M., Marcus Liebermann, Bart A. Nijmeijer, Ottmann, O.G., Nijmeijer, Bart A., Badura, S., Susanne Badura, Wystub, Sylvia, Pfeifer, H., J H Frederik Falkenburg, Tamara Tesanovic (485224), Martin Ruthardt (66634), Wystub, S., Nijmeijer, B.A., Ruthardt, M., Tesanovic, T., Badura, Susanne, Heike Pfeifer (485225), J. H. Frederik Falkenburg (210432), Liebermann, Marcus, Badura Susanne, Ottmann Oliver G., Pfeifer Heike, Liebermann Marcus, Wystub Sylvia, Tesanovic Tamara, Ruthardt Martin, Nijmeijer Bart A., Falkenburg J. H. Frederik   +47 more
core   +1 more source

The protective effect of Apelin-13 against cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences, 2023
Objective(s): To determine the protective effect of Apelin-13 on cardiac hypertrophy through activating the PI3K-AKT-mTOR signaling pathway.Materials and Methods: The phenylephrine-induced cardiomyocyte hypertrophy model was established in H9C2 cells in ...
Yu Peng, Ruan Jingming, Chen Shaowen, Huang Feng, Zhu Pengli   +4 more
doaj   +1 more source