Results 11 to 20 of about 388,210 (312)
, 2015 The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells.
Turner, Martin +2 more
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Frontiers in Oncology, 2012 The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3’-hydroxyl group of phosphatidylinositol and phosphoinositides.
Enriqueta Felip +3 more
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Novel PI3K and mTOR selective inhibitors to deconvolute PI3K signaling
, 2021 Phosphoinositide 3-kinase (PI3K) signaling has key roles in the regulation of cellular processes such as cell growth, proliferation, and metabolism. Constitutive activation of PI3K in tumors is frequent and drives cancer progression.
Keles, Erhan
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Cardiac PI3K p110α attenuation delays aging and extends lifespan
Cell Stress, 2022 Phosphoinositide 3-kinase (PI3K) is a key component of the insulin signaling pathway that controls cellular metabolism and growth. Loss-of-function mutations in PI3K signaling and other downstream effectors of the insulin signaling pathway extend the ...
Mahmoud Abdellatif +5 more
doaj +1 more source
Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy [PDF]
Journal of Integrative Neuroscience, 2021 Overactivation of the PI3-K/Akt/mTOR signaling pathway and inhibition of autophagy in the brain are involved in Alzheimer’s disease. The present paper’s goal was to explore the potential mechanisms of geniposide to protect against Alzheimer’s disease.
Dong-Xing Liu +5 more
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Archives of Medical Science, 2022 Introduction Systemic inflammatory and immunosuppressive incidents constitute a significant hallmark of the adverse effects of RBC transfusion on red blood cells. These adverse side effects are seemingly associated with old blood transfusions; therefore,
Jia-Ming Xu +7 more
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The PTEN–PI3K Axis in Cancer [PDF]
Biomolecules, 2019 The PI3K–AKT–mTOR signal transduction pathway regulates a variety of biological processes including cell growth, cell cycle progression and proliferation, cellular metabolism, and cytoskeleton reorganization. Fine-tuning of the phosphatidylinositol 3-kinase (PI3K) pathway signaling output is essential for the maintenance of tissue homeostasis and ...
Antonella Papa, Pier Paolo Pandolfi
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Effect of eight weeks of swimming training and CBD oil consumption on PI3K and ERK gene expression in the heart tissue of rats with myocardial infarction [PDF]
Journal of Shahrekord University of Medical Sciences, 2022 Background and aims: Cannabidiol (CBD) oil consumption can positively contribute to controlling the cardiovascular risk factors. Exercise can also be effective in rehabilitating myocardial infarction by strengthening muscle tissue. This study, therefore,
Mostafa Safian Boldaji +2 more
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Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits
Frontiers in Bioscience-Landmark, 2022 Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition,
Arthur J. Chu
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Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer [PDF]
, 2011 The phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases, which are implicated in signal transduction pathways and modulation of fundamental cellular activities such as cell growth, proliferation, differentiation, motility, survival and
Cmiljanović, Nataša
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