Results 11 to 20 of about 336,763 (266)
EVALUATION OF PTEN AND PI3K/AKT EXPRESSIONS IN STANOZOLOL-TREATED RAT KIDNEYS
İstanbul Tıp Fakültesi Dergisi, 2022 Objective: Stanozolol is an anabolic androgenic steroid (AAS) that is widely used by teenagers and athletes in bodybuilding, sports, and athletics. The potential effects of stanozolol in kidney functions have not been defined.
Tuğba Kotil +2 more
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Platelets, 2022 Platelet activation by adenosine diphosphate (ADP) is mediated through two G-protein-coupled receptors, P2Y1 and P2Y12, which signal through Gq and Gi, respectively.
Carol Dangelmaier, Satya P Kunapuli
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Cardiac PI3K p110α attenuation delays aging and extends lifespan
Cell Stress, 2022 Phosphoinositide 3-kinase (PI3K) is a key component of the insulin signaling pathway that controls cellular metabolism and growth. Loss-of-function mutations in PI3K signaling and other downstream effectors of the insulin signaling pathway extend the ...
Mahmoud Abdellatif +5 more
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Geniposide protection against Aβ1-42 toxicity correlates with mTOR inhibition and enhancement of autophagy [PDF]
Journal of Integrative Neuroscience, 2021 Overactivation of the PI3-K/Akt/mTOR signaling pathway and inhibition of autophagy in the brain are involved in Alzheimer’s disease. The present paper’s goal was to explore the potential mechanisms of geniposide to protect against Alzheimer’s disease.
Dong-Xing Liu +5 more
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Archives of Medical Science, 2022 Introduction Systemic inflammatory and immunosuppressive incidents constitute a significant hallmark of the adverse effects of RBC transfusion on red blood cells. These adverse side effects are seemingly associated with old blood transfusions; therefore,
Jia-Ming Xu +7 more
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Effect of eight weeks of swimming training and CBD oil consumption on PI3K and ERK gene expression in the heart tissue of rats with myocardial infarction [PDF]
Journal of Shahrekord University of Medical Sciences, 2022 Background and aims: Cannabidiol (CBD) oil consumption can positively contribute to controlling the cardiovascular risk factors. Exercise can also be effective in rehabilitating myocardial infarction by strengthening muscle tissue. This study, therefore,
Mostafa Safian Boldaji +2 more
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Quarter-Century Explorations of Bioactive Polyphenols: Diverse Health Benefits
Frontiers in Bioscience-Landmark, 2022 Polyphenols, members of phytochemical superfamily rich in vegetables and fruits, include flavonoids, non-flavonoids, and phenolic acids. Their biological effects includes classical antioxidation (e.g., radical-scavenging, metal chelating, NOX inhibition,
Arthur J. Chu
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The PTEN–PI3K Axis in Cancer [PDF]
Biomolecules, 2019 The PI3K–AKT–mTOR signal transduction pathway regulates a variety of biological processes including cell growth, cell cycle progression and proliferation, cellular metabolism, and cytoskeleton reorganization. Fine-tuning of the phosphatidylinositol 3-kinase (PI3K) pathway signaling output is essential for the maintenance of tissue homeostasis and ...
Antonella Papa, Pier Paolo Pandolfi
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target.
Xinyuan Xu +6 more
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Drug Design, Development and Therapy, 2022 Zheng X, Yang S, Zhang R, Wang S, Li G, Zhou S. Drug Des Devel Ther. 2019;13:3171–3180. The authors have advised due to an error that occurred inadvertently at the time of figure assembly, Figure 5J is incorrect.
Zheng X +5 more
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