Results 1 to 10 of about 495,928 (201)
Targeting the MAPK Pathway in KRAS-Driven Tumors
Cancer Cell, 2020 KRAS mutations occur in a quarter of all of human cancers, yet no selective drug has been approved to treat these tumors. Despite the recent development of drugs that block KRASG12C, the majority of KRAS oncoproteins remain undruggable.
Mariano Barbacid, Matthias Drosten
exaly +2 more sources
Understanding MAPK Signaling Pathways in Apoptosis
International Journal of Molecular Sciences, 2020 MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological processes through multiple cellular mechanisms. In most of these processes, such as apoptosis, MAPKs have a dual role since they can act as activators or ...
JOSÉ Lopez
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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
International Journal of Molecular Sciences, 2020 Mitogen-activated protein kinase (MAPK) pathways represent ubiquitous signal transduction pathways that regulate all aspects of life and are frequently altered in disease.
Walter Kolch +2 more
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A Comprehensive Review on MAPK: A Promising Therapeutic Target in Cancer
Cancers, 2019 The mitogen-activated protein kinase (MAPK) pathway is an important bridge in the switch from extracellular signals to intracellular responses. Alterations of signaling cascades are found in various diseases, including cancer, as a result of genetic and ...
Ioana Berindan Neagoe +2 more
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MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma
Cancers, 2021 Simple Summary The mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling pathway is frequently activated in liver cancer, which is one of the most lethal cancers in humans.
Hyuk Moon +2 more
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RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
Cancer Cell, 2017 SUMMARY Constitutive activation of Gαq signaling by mutations in GNAQ or GNA11 occurs in over 80% of uveal melanomas (UMs) and activates MAPK. Protein kinase C (PKC) has been implicated as a link, but the mechanistic details remained unclear.
Sophie Thornton +2 more
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MAPK signal pathways in the regulation of cell proliferation in mammalian cells
Cell Research, 2002 Wei Zhang, Hui Liu
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Bone & Joint Research, 2023 Aims: Osteoarthritis (OA) is a prevalent joint disorder with inflammatory response and cartilage deterioration as its main features. Dihydrocaffeic acid (DHCA), a bioactive component extracted from natural plant (gynura bicolor), has demonstrated anti ...
Rui Lu +7 more
doaj +1 more source
Insidious Onset of Pulmonary Langerhans Cell Histiocytosis During Oncological Follow-Up
Journal of the Belgian Society of Radiology, 2022 Teaching Point: Pulmonary Langerhans cell histiocytosis (PLCH) has to be included in the differential diagnosis of cystic pulmonary lesions on chest computed tomography (CT).
Nico Hustings +2 more
doaj +1 more source
Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies
Signal Transduction and Targeted Therapy, 2023 Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis, chemoresistance, and the mechanistic backgrounds of
M. Bahar, Hyun Joon Kim, D. Kim
semanticscholar +1 more source