Results 11 to 20 of about 495,928 (201)
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases [PDF]
Microbiology and Molecular Biology Reviews, 2011 SUMMARYThe mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs by relaying extracellular signals to intracellular responses. In mammals, there are more than a dozen MAPK enzymes that coordinately regulate cell proliferation, differentiation, motility, and survival.
Marie Cargnello, Philippe P Roux
semanticscholar +4 more sources
Frontiers in Neurology, 2013 The nature of "toxic" tau in Alzheimer's disease (AD) has been unclear. During pathogenesis, the importance of tau oligomerization vs. tau phosphorylation is controversial and the investigation of both remains critical toward defining the "toxicity" of tau.
Leugers, Chad J. +3 more
openaire +3 more sources
Journal of Pure and Applied Microbiology, 2021 Computational databases and tools in recent times have been proved to provide an essential aid for anticancer studies in the field of oncology. Molecular docking studies facilitate the structural diversity of plant-derived phytomolecules having ...
Amar Shankar +8 more
doaj +1 more source
ERK/MAPK signalling pathway and tumorigenesis
Experimental and Therapeutic Medicine, 2020 Mitogen-activated protein kinase (MAPK) cascades are key signalling pathways that regulate a wide variety of cellular processes, including proliferation, differentiation, apoptosis and stress responses.
Yan-Jun Guo +5 more
semanticscholar +1 more source
The Winner Takes It All: Auxin–The Main Player during Plant Embryogenesis
Cells, 2020 In plants, the first asymmetrical division of a zygote leads to the formation of two cells with different developmental fates. The establishment of various patterns relies on spatial and temporal gene expression, however the precise mechanism responsible
Konrad Winnicki
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MAPK15 controls mitochondrial fitness and contributes to prevent cellular senescence
Autophagy Reports, 2022 Aberrant production of reactive oxygen species (ROS) from dysfunctional mitochondria leads to oxidative stress and DNA damage, which induces the cellular senescence stress response pathway.
Lorenzo Franci +2 more
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Protein kinases as therapeutic targets to develop anticancer drugs with natural alkaloids
Frontiers in Bioscience-Landmark, 2021 Backgroud: Protein kinases play an important role in cell proliferation, differentiation, mobility and cell cycle arrest etc. These enzymes act as important targets in developing anticancer agents.
Hanlin Ye +10 more
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Reactive oxygen species mediate TNF-α-induced inflammatory response in bone marrow mesenchymal cells [PDF]
Iranian Journal of Basic Medical Sciences, 2019 Objective(s): It is generally believed that the inflammatory response in bone marrow mesenchymal stem cells (BMSCs) transplantation leads to poor survival and unsatisfactory effects, and is mainly mediated by cytokines, including interleukin-1β (IL-1β ...
Liuzhong Wu, Yaping Pan
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Langerhans Cell Histiocytosis in Adults: Treatment Opportunities of Today
Клиническая онкогематология, 2021 Langerhans cell histiocytosis (LCH) is an extremely rare disease associated with tissue infiltration by pathological cells which are phenotypically similar to normal Langerhans cells.
Vitalii Dmitrievich Latyshev +1 more
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Fruit Research, 2023 Melatonin (MT) plays an important role in plant growth and development, and response to biotic and abiotic stresses. Salt stress is one of the major abiotic stresses affecting plant growth and distribution.
Wenhui Zhu +8 more
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