Results 31 to 40 of about 495,928 (201)
MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types
Frontiers in Bioscience-Landmark, 2022 The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer.
Khoa Nguyen +11 more
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Chromatin-tethered MAPKs [PDF]
Current Opinion in Cell Biology, 2013 Mitogen-activated protein kinases (MAPKs) are a family of protein kinases that are essential nodes in many cellular regulatory circuits including those that take place on DNA. Most members of the four MAPK subgroups that exist in canonical three kinase cascades-extracellular signal-regulated kinases 1 and 2 (ERK1/2), ERK5, c-Jun N-terminal kinases ...
Aileen M, Klein +2 more
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International Journal of Molecular Sciences, 2022 Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is limited due to the metastasis of cells to distant locations of the body through the blood and lymphatic drainage. Most of the anticancer therapeutic options focus mainly on the inhibition of tumor cell growth or the induction of cell death, and do not consider ...
Mateusz Kciuk +4 more
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PSMA redirects MAPK to PI3K-AKT signaling to promote prostate cancer progression
Molecular & Cellular Oncology, 2017 Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-
Leslie Ann Caromile, Linda H. Shapiro
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Involvement of p38 MAPK in Synaptic Function and Dysfunction
International Journal of Molecular Sciences, 2020 Many studies have revealed a central role of p38 MAPK in neuronal plasticity and the regulation of long-term changes in synaptic efficacy, such as long-term potentiation (LTP) and long-term depression (LTD).
Chiara Falcicchia +4 more
semanticscholar +1 more source
Pharmaceutical Biology, 2017 Context: Punica granatum L (Punicaceae) flower is an important diabetes treatment in oriental herbal medicine. Objective: This study investigates the inflammation effects of pomegranate flower (PFE) ethanol extract in LPS-induced RAW264.7 cells ...
Jianjun Xu +2 more
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Cell Stress, 2020 The widespread application of immune-checkpoint blockade (ICB) has resulted in unprecedented response rates in patients with immunogenic cancers, such as melanoma and lung cancer.
Daniel Baumann, Rienk Offringa
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Alhiwar: Jurnal Ilmu dan Teknik DakwahChildren with special needs also have the right to develop mental and spiritual aspects so that they develop optimally according to their circumstances.
Rahmiyati Rahmiyati, Hapiz Al Ansyari
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Translational Neuroscience, 2022 Mitogen-activated protein kinase (MAPK) pathway is a major mechanism of acute brain damage in ischemic stroke. Pre-ischemic exercise is an effective method to reduce ischemic injury.
Gao Zhen-Kun +5 more
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Clinical and Experimental Hypertension, 2021 Objective: Hypertension is associated with a low-grade systemic inflammation in cardiovascular system. Macrophage infiltration may initiate an inflammatory process that contributes to vascular and ventricular remodeling in hypertensive human and mice ...
Yuantong Tian +5 more
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