Results 51 to 60 of about 495,928 (201)

Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway

Journal of Pain Research, 2021
Guangyao Ye,1,* Chunyan Lin,1,* Yu Zhang,1 Zihan Ma,2 Yuebo Chen,1 Lingsi Kong,1 Liyong Yuan,1 Tao Ma3 1Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, 315040, People’s Republic of China; 2School of Medicine, Ningbo University, Ningbo ...
Ye G, Lin C, Zhang Y, Ma Z, Chen Y, Kong L, Yuan L, Ma T   +7 more
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MAPK-ERK Pathway

International Journal of Molecular Sciences, 2023
The name extracellular signal-regulated kinase (ERK) was first used for a cell cycle regulating Ser/Thr protein kinase cloned in mammalian cells [...]
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Salidroside inhibits MAPK, NF-κB, and STAT3 pathways in psoriasis-associated oxidative stress via SIRT1 activation

Redox Report, 2019
Objectives: To unveil the role of SIRT1 in limiting oxidative stress in psoriasis and to further discuss the therapeutic prospects of salidroside in psoriasis.
Fengli Xu, Jixiang Xu, Xia Xiong, Yongqiong Deng   +3 more
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Oroxin B Attenuates Ovariectomy-Induced Bone Loss by Suppressing Osteoclast Formation and Activity

Drug Design, Development and Therapy, 2021
Jun-ming Huang, Chen-zhong Wang, Shun-yi Lu, Zhe Wang, Zuo-qin Yan Department of Orthopaedics, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of ChinaCorrespondence: Zuo-qin Yan 180 Feng Lin Road, Xuhui District, Shanghai ...
Huang JM, Wang CZ, Lu SY, Wang Z, Yan ZQ
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Molecular Mechanisms of Mechanical Stress Response during Chondrogenesis

Journal of Biomechanical Science and Engineering, 2009
Muscloskeletal tissues, bone, cartilage, muscles and tendons regulate and support the body's actions and are differentiated from mesenchymal stem cells.
Ichiro TAKAHASHI, Taisuke MASUDA, Kumiko KOHSAKA, Fumie TERAO, Takahisa ANADA, Yasuyuki SASANO, Teruko TAKANO-YAMAMOTO, Osamu SUZUKI   +7 more
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Comprehensive Transcriptome and Metabolome Analysis of Hemp (Cannabis Sativa L.) in Soil Under NaCl Stress

Journal of Natural Fibers, 2023
Planting economic crops in soil with salt imbalances can improve land use efficiency. Hemp, which can be planted in low-salinity soil, is a crop with a very high economic value. To reveal the salt tolerance mechanism of hemp, the leaves of Longma #3 and #
Ming Zhang, Liguo Zhang, Guijiang Wang, Xutang Huang, Zhenhua Guo   +4 more
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p38 MAPK in MDS

Aging, 2015
Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic malignancies occurring mainly in the elderly and characterized by the defective production of mature blood cells. MDS subtypes can be classified as "low-risk" and "high-risk" syndromes on the basis of their risk of progression to acute leukemia.
Gañán-Gómez, I. (Irene), Bohannan, Z.S. (Zachary S.), Garcia-Manero, G. (Guillermo)   +2 more
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Effects and Potential Mechanism of Zhuyu Pill Against Atherosclerosis: Network Pharmacology and Experimental Validation

Drug Design, Development and Therapy, 2023
Yingying Pan,1,* Xianrong Feng,2,* Wei Song,1,* Xin Zhou,1 Zhen Zhou,3 Gaoyang Chen,1 Tao Shen,1 Xiaobo Zhang1 1School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Hospital of ...
Pan Y, Feng X, Song W, Zhou X, Zhou Z, Chen G, Shen T, Zhang X   +7 more
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Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

Cancer Biology & Therapy, 2022
In this study, we report a differential response of mitogen-activated protein kinase–kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients’ tumor-derived cell cultures.
Myles Vigoda, Chase Mathieson, Nathaniel Evans, Carolyn Hale, Jennifer Jennings, Olivia Lucero, Sophia Jeng, Daniel Bottomly, Daniel Clayburgh, Peter Andersen, Ryan Li, Daniel Petrisor, Jeffrey W. Tyner, Shannon McWeeney, Molly Kulesz-Martin   +14 more
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JNK-Dependent cJun Phosphorylation Mitigates TGFβ- and EGF-Induced Pre-Malignant Breast Cancer Cell Invasion by Suppressing AP-1-Mediated Transcriptional Responses

Cells, 2019
Transforming growth factor-β (TGFβ) has both tumor-suppressive and tumor-promoting effects in breast cancer. These functions are partly mediated through Smads, intracellular transcriptional effectors of TGFβ.
Anders Sundqvist, Oleksandr Voytyuk, Mohamed Hamdi, Herman E. Popeijus, Corina Bijlsma- van der Burgt, Josephine Janssen, John W.M. Martens, Aristidis Moustakas, Carl-Henrik Heldin, Peter ten Dijke, Hans van Dam   +10 more
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