Results 61 to 70 of about 495,928 (201)

Roles of Cyclic AMP Response Element Binding Activation in the ERK1/2 and p38 MAPK Signalling Pathway in Central Nervous System, Cardiovascular System, Osteoclast Differentiation and Mucin and Cytokine Production

International Journal of Molecular Sciences, 2019
There are many downstream targets of mitogen-activated protein kinase (MAPK) signalling that are involved in neuronal development, cellular differentiation, cell migration, cancer, cardiovascular dysfunction and inflammation via their functions in ...
Yasuhiko Koga, H. Tsurumaki, Haruka Aoki‐Saito, Makiko Sato, Masakiyo Yatomi, K. Takehara, T. Hisada   +6 more
semanticscholar   +1 more source

Punicalagin Attenuates LPS-Induced Inflammation and ROS Production in Microglia by Inhibiting the MAPK/NF-κB Signaling Pathway and NLRP3 Inflammasome Activation

Journal of Inflammation Research, 2022
Jung Lo,1,2 Ching-Chih Liu,3,4 Yueh-Shan Li,3 Po-Yen Lee,3,5 Po-Len Liu,6 Pei-Chang Wu,1,2 Tzu-Chieh Lin,7 Chi-Shuo Chen,8 Chien-Chih Chiu,9 Yu-Hung Lai,3,5,10 Yo-Chen Chang,3,5,10 Hsin-En Wu,3 Yuan-Ru Chen,3 Yu-Kai Huang,3,11 Shu-Pin Huang,1,12– 14 Shu ...
Lo J, Liu CC, Li YS, Lee PY, Liu PL, Wu PC, Lin TC, Chen CS, Chiu CC, Lai YH, Chang YC, Wu HE, Chen YR, Huang YK, Huang SP, Wang SC, Li CY   +16 more
doaj  

Recent Advances in the Inhibition of p38 MAPK as a Potential Strategy for the Treatment of Alzheimer’s Disease

Molecules, 2017
P38 mitogen-activated protein kinase (MAPK) is a crucial target for chronic inflammatory diseases. Alzheimer’s disease (AD) is characterized by the presence of amyloid plaques and neurofibrillary tangles in the brain, as well as neurodegeneration, and ...
Jong Kil Lee, Nam‐Jung Kim
semanticscholar   +1 more source

The effect of 8 weeks of interval training combined with the consumption of cineole, linalool, and bourbonene on MAPK/Arc gene expression and learning in rats with Alzheimer’s disease [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: This research aimed to investigate the effect of 8 weeks of interval training and the use of cineole, linalool, and bourbonene on MAPK/Arc gene expression and learning in Alzheimer’s disease (AD) rats.
Elham Majidi, Khosro Jalali Dehkordi, Farzaneh Taghian, Seyed Ali Hosseini   +3 more
doaj   +1 more source

A sestrin-dependent Erk/Jnk/p38 MAPK activation complex inhibits immunity during ageing

Nature Immunology, 2017
Mitogen-activated protein kinases (MAPKs) including Erk, Jnk and p38 regulate diverse cellular functions and are thought to be controlled by independent upstream activation cascades. Here we show that the sestrins bind to and coordinate simultaneous Erk,
A. Lanna, D. Gomes, B. Muller-Durovic, T. McDonnell, D. Escors, D. Gilroy, J. H. Lee, M. Karin, A. Akbar   +8 more
semanticscholar   +1 more source

A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types

npj Precision Oncology, 2018
KRAS- and BRAF-mutant tumors are often dependent on MAPK signaling for proliferation and survival and thus sensitive to MAPK pathway inhibitors. However, clinical studies have shown that MEK inhibitors are not uniformly effective in these cancers ...
Marie-Claire Wagle, Daniel C. Kirouac, Christiaan Klijn, Bonnie Liu, Shilpi Mahajan, M. Junttila, John G. Moffat, M. Merchant, L. Huw, M. Wongchenko, K. Okrah, S. Srinivasan, Z. Mounir, T. Sumiyoshi, Peter M. Haverty, R. Yauch, Yibing Yan, O. Kabbarah, G. Hampton, L. Amler, S. Ramanujan, M. Lackner, Shih-Min A. Huang   +22 more
semanticscholar   +1 more source

Negative feedback regulation of the ERK1/2 MAPK pathway

Cellular and Molecular Life Sciences, 2016
The extracellular signal-regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) signalling pathway regulates many cellular functions, including proliferation, differentiation, and transformation.
D. Lake, Sonia A. L. Corrêa, Jürgen Müller   +2 more
semanticscholar   +1 more source

Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis

International Journal of Molecular Sciences, 2018
Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing prevalence in western societies. Statins are widely applied in atherosclerosis therapy, whereas no pharmacological interventions are available for the treatment of ...
A. Reustle, M. Torzewski
semanticscholar   +1 more source

Inhibition of c-Jun N-terminal kinase (JNK) suppresses porcine oocyte ageing in vitro

Czech Journal of Animal Science, 2013
Oocyte ageing is a complex of processes that occur when matured in vitro oocytes are, after reaching the metaphase II stage, exposed to further in vitro culture.
M. Sedmíková, J. Petr, A. Dörflerová, J. Nevoral, B. Novotná, T. Krejčová, E. Chmelíková, L. Tůmová   +7 more
doaj   +1 more source

Role of MAPK/MNK1 signaling in virus replication

Virus Research, 2018
Highlights • Viruses are known to exploit cellular signaling pathways.• MAPK is a major cell signaling pathway activated by diverse group of viruses.• MNK1 regulates both cap-dependent and IRES-mediated mRNA translation.• This review discuss the role of ...
Ram Kumar, Nitin Khandelwal, Riyesh Thachamvally, B. N. Tripathi, S. Barua, S. K. Kashyap, S. Maherchandani, Naveen Kumar   +7 more
semanticscholar   +1 more source