Results 81 to 90 of about 495,928 (201)

Atypical MAPKs in cancer

The FEBS Journal
Impaired kinase signalling leads to various diseases, including cancer. At the same time, kinases make up the majority of the druggable genome and targeting kinase activity has proven to be a successful first‐line therapy for many cancers. Among the best‐studied kinases are the mitogen‐activated protein kinases (MAPKs), which regulate cell ...
Katrin Dahm, Parthiban Vijayarangakannan, Hans‐Peter Wollscheid, Hansjörg Schild, Krishnaraj Rajalingam   +4 more
openaire   +2 more sources

Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload

Drug Design, Development and Therapy
Xi-Xi Hou,1,2,* Shuang Wang,1,3,* Xiao-Xia Ma,1,2,* Ying Wen,1,3,* Zhi-Jun Li,4 Xu-Yun Liu,5 Xing Zhang,3 Yang Zhang,6 Xiang-Yang Qin2 1College of Life Sciences, Northwest University, Xi’an, People’s Republic of China; 2Department of ...
Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY   +8 more
doaj  

ARID1B Gene Deletion Promotes the Proliferation, Migration and Invasion 
of NSCLC Cells

Chinese Journal of Lung Cancer
Background and objective Abnormalities of the switch/sucrose nonfermentable (SWI/SNF) chromatin-remodeling complex are closely related to various cancers, and ARID1B (AT-rich interaction domain 1B) is one of the core subunits of the SWI/SNF complex ...
Linlin ZHU, Xuchao ZHANG
doaj   +1 more source

ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions

Microbiology and Molecular Biology Reviews, 2004
Philippe P Roux, J. Blenis
semanticscholar   +1 more source

Ligustroside derived from Ligustrum japonicum inhibits melanogenesis via blocking the MAPK and PKA/CREB signaling pathways

Asian Pacific Journal of Tropical Biomedicine
Objective: To investigate the anti-melanogenic potential of ligustroside isolated from Ligustrum japonicum. Methods: The cytotoxicity of ligustroside was tested via MTT assay.
Xian-Rong Zhou, Fatih Karadeniz, Jung Hwan Oh, Youngwan Seo, Chang-Suk Kong   +4 more
doaj   +1 more source

Pathological roles of MAPK signaling pathways in human diseases.

Biochimica et Biophysica Acta, 2010
E. K. Kim, E. Choi
semanticscholar   +1 more source

PI3K Regulates Wild-type RAS Signaling to Confer Resistance to KRAS Inhibition. [PDF]

Cancer Res
Ge X, Singh J, Li W, Markham CS, Ruiz CF, Stites EC, Bhattacharyya M, Liu Y, Muzumdar MD.   +8 more
europepmc   +1 more source

MEK/MAPK Inhibitors [PDF]

Journal of Thoracic Oncology, 2010
openaire   +2 more sources

Effects of P38 MAPK Pathway Inhibition on the Metabolism of Periodontal Ligament Fibroblasts During Inflammation. [PDF]

J Cell Mol Med
Qian C, Gu Y, Gao F, Xu Z, Li J, Liu S, He R, Zhong L, Wang J.   +8 more
europepmc   +1 more source

The dual axis of tumorigenesis: MAPK and PI3K/AKT pathways in papillary thyroid carcinoma. [PDF]

Oncoscience
Rathod G, Parmar P.
europepmc   +1 more source