Results 71 to 80 of about 495,928 (201)

Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Assesmen Program Pelaksanaan Otonomi Pendidikan Karakter di MAPK (Madrasah Aliyah Pr0gram Khusus) Syaikh Zainuddin NW Anjani Lombok Timur NTB

Palapa: Jurnal Studi Keislaman dan Ilmu Pendidikan, 2014
Penelitian ini bertujuan untuk mengungkapkan proses pengambilan keputusan, pengelolaan kelembagaan, pengelolaan program, proses belajar mengajar, proses Assesmen, hubungan kerjasama dan partisipasi, sikap kemandirian, keterbukaan, keberlanjutan program ...
Ittihad Ittihad
doaj   +1 more source

Protective Effect of the Total Alkaloid Extract from Bulbus Fritillariae pallidiflorae in a Mouse Model of Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease

International Journal of COPD
Xiaoyu Wang,1 Er-Bu AGA,2 Wai Ming Tse,3 Kathy Wai Gaun Tse,3 Bengui Ye1,2 1Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug ...
Wang X, AGA EB, Tse WM, Tse KWG, Ye B
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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

eLife, 2017
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD+ biosynthetic enzyme NMNAT2 that inhibits ...
Lauren J Walker, Daniel W. Summers, Y. Sasaki, E. Brace, J. Milbrandt, A. Diantonio   +5 more
semanticscholar   +1 more source

She-Chuang-Si-Wu-Tang Alleviates Inflammation and Itching Symptoms in a Psoriasis Mouse Model by Regulating the Th17/IL-17 Axis via the STAT3/MAPK Pathways

Journal of Inflammation Research
Weixiong Chen,1,2,* Jianqiang Liang,3,* Shuang He,1,4,5 Qingsong Liang,1,4,5 Wenting Tian,6 Aobo Lu,1 Demin Li,1 Zhicheng Huang,1 Guanyi Wu1,4,5 1College of Basic Medicine, Guangxi University of Chinese Medicine, Nanning, Guangxi, 530299, People ...
Chen W, Liang J, He S, Liang Q, Tian W, Lu A, Li D, Huang Z, Wu G   +8 more
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Cisplatin Suppresses Proliferation of Ovarian Cancer Cells through Inhibition Akt and Modulation MAPK Pathways

Korean Journal of Clinical Laboratory Science, 2020
Cisplatin (CDDP) is a chemotherapy agent used for patients with ovarian cancers. CDDP activates multiple signaling pathways, which causes various cellular reactions according to the type of cancer cells. Therefore, it is difficult to clearly conclude its
Jae-Sun Choi
doaj   +1 more source

Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth

Molecules and Cells, 2015
Summary Ras is mutated in up to 30% of cancers, including 90% of pancreatic ductal adenocarcinomas, causing it to be constitutively GTP-bound, and leading to activation of downstream effectors that promote a tumorigenic phenotype.
Jennifer A. Kashatus, Aldo Nascimento, Lindsey J. Myers, A. Sher, F. Byrne, Kyle L. Hoehn, C. Counter, David F. Kashatus   +7 more
semanticscholar   +1 more source

The MAPK pathway across different malignancies: A new perspective

Cancer, 2014
The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway is activated by upstream genomic events and/or activation of multiple signaling events in which information coalesces at this important nodal pathway point.
Mauricio Burotto, Victoria L. Chiou, Jung-Min Lee, E. C. Kohn   +3 more
semanticscholar   +1 more source

The frequency of NRAS mutation in stool samples of Iranian colorectal cancers compared to Finnish patients

Journal of Research in Medical Sciences
Background: Stools from colorectal cancer patients are noninvasive samples that could be used to compare the frequency of hotspot mutations between two different ethnic cohorts.
Farideh Saberi, Omar Youssef, Arto Kokkola, Mahsa Khodadoostan, Pauli Puolakkainen, Rasoul Salehi, Sakari Knuutila   +6 more
doaj   +1 more source

Linarin Protects Against CCl4-Induced Acute Liver Injury via Activating Autophagy and Inhibiting the Inflammatory Response: Involving the TLR4/MAPK/Nrf2 Pathway

Drug Design, Development and Therapy, 2023
Lulu Li,1,2 Yan Lan,3 Fuqian Wang,1,2 Tiexiang Gao1 1Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, People’s Republic of China; 2Department of Pharmacy, Wuhan NO.1 Hospital, Wuhan, Hubei, People’s Republic of China; 3Department ...
Li L, Lan Y, Wang F, Gao T
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