Results 21 to 30 of about 495,928 (201)
Functional Roles of JNK and p38 MAPK Signaling in Nasopharyngeal Carcinoma
International Journal of Molecular Sciences, 2022 c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) family members integrate signals that affect proliferation, differentiation, survival, and migration in a cell context- and cell type-specific way.
Lesley Jia Wei Pua +6 more
semanticscholar +1 more source
Effect and mechanism of H. pylori in regulation of REDD1 expression in gastric mucosa
Di-san junyi daxue xuebao, 2022 Objective Regulated in development and DNA damage responses-1 (REDD1) is a conserved and ubiquitous protein, and is induced in response to multiple stimuli. However, its regulation, function and clinical relevance in Helicobacter pylori (H.
YAN Zongbao +4 more
doaj +1 more source
Frontiers in Bioscience-Landmark, 2022 Backgrounds: Dental avulsion due to trauma, especially in young patients, is a worldwide problem, requiring tooth replacement. Delayed replantation could cause tooth loss when the cementum is severely damaged.
Jiawen Yong +7 more
doaj +1 more source
Protein kinases as potential anticandidal drug targets
Frontiers in Bioscience-Landmark, 2020 Candidal infections are increasing at an alarming rate due to hospital acquired infections causing high mortality rates worldwide. Moreover, the emergence of drug resistant Candida strains is the major impediment against effective therapeutics.
Shweta Singh +3 more
doaj +1 more source
Animal Cells and Systems, 2021 Endometrial cancer is the most common gynecological cancer in the developed countries. Type II transmembrane serine proteases 4 (TMPRSS4) is a newly discovered transmembrane protein, which may be related to the invasion, metastasis of the tumor and the ...
Huan Xiao +4 more
doaj +1 more source
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Journal of Hematology & Oncology, 2020 Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40%
Jimin Yuan +3 more
semanticscholar +1 more source
Jolkinolide B induces reactive oxygen species accumulation and endoplasmic reticulum stress and inhibits MAPK and AKT signaling activation in renal cancer cells [PDF]
Journal of Men's HealthTo investigate the impact of Jolkinolide B (JB) on renal cell carcinoma (RCC), we treated RCC cell lines with various concentrations of JB (0, 5, 25, 50 and 100 μM) for 24 hours and assessed cell viability using the cell counting kit-8 (CCK-8 ...
Xuan Wu +6 more
doaj +1 more source
MAPK and β-Catenin signaling: implication and interplay in orthodontic tooth movement
Frontiers in Bioscience-Landmark, 2022 Orthodontic tooth movement (OTM) requires the orthodontic forces (compressive and tensile strain) to subject to the periodontal ligament and mechanosensory cells in the periodontium and to achieve mechanotransduction by mechanoreceptors.
Jiawen Yong +3 more
doaj +1 more source
Quercetin induces cell death by caspase-dependent and p38 MAPK pathway in EGFR mutant lung cancer cells [PDF]
Kosin Medical Journal, 2016 Objectives The aim of this study was whether quercetin induces cell death by caspase and MAPK signaling pathway in EGFR mutant lung cancer cells Methods PC-9 cells, EGFR mutant lung cancer cells, were treated various times and concentrations of quercetin
Eun Jin Lim, Jeunghoon Heo, Young-Ho Kim
doaj +1 more source
The roles of MAPKs in disease [PDF]
Cell Research, 2008 MAP kinases transduce signals that are involved in a multitude of cellular pathways and functions in response to a variety of ligands and cell stimuli. Aberrant or inappropriate functions of MAPKs have now been identified in diseases ranging from cancer to inflammatory disease to obesity and diabetes.
Michael C, Lawrence +11 more
openaire +2 more sources