Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Biomolecules, 2019 The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego +4 more
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Focal adhesion kinase-regulated signaling events in human cancer
Biomolecular Concepts, 2012 Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase that is highly expressed or activated in many human cancers. Under specific scenarios, FAK can regulate cell proliferation, cell survival, cell migration and invasion, and has been ...
Fu Wei +2 more
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The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
Biomolecules, 2019 In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these ...
Hyeyoun Chang +2 more
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adaptive capabilities of the pi3k/akt/mtor pathway in acute myeloid leukemia revealed by the use of selective inhibitors [PDF]
, 2013 Because of its aberrant activation, the PI3K/AKT/mTOR signaling pathway represents a pharmacological target in blast cells from patients with acute myelogenous leukemia (AML).
Bertacchini, Jessika <1980>
core +1 more source
Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]
, 2014 The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Ward, Richard +10 more
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Plinabulin exerts an anti-proliferative effect via the PI3K/AKT/mTOR signaling pathways in glioblastoma [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Plinabulin, a marine-derived anticancer drug targeting microtubules, exhibits anti-cancer effects on glioblastoma cells. However, its therapeutic potential, specifically for glioblastoma treatment, remains underexplored.
Rouxin Wang +7 more
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Vortioxetine exhibits anti-glioblastoma activity via the PI3K-Akt signaling pathway [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Glioblastoma multiforme (GBM) presents a significant challenge in oncology due to its highly aggressive nature and inherent resistance to conventional therapeutic interventions.
Huan-Qi Zhang +6 more
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Targeting potassium channels and autophagy to defeat chemoresistance
Molecular & Cellular Oncology, 2020 Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant ...
Giulia Petroni
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Microglia Mediated Neuroinflammation: Focus on PI3K Modulation
Biomolecules, 2020 Immune activation in the central nervous system involves mostly microglia in response to pathogen invasion or tissue damage, which react, promoting a self-limiting inflammatory response aimed to restore homeostasis.
Antonia Cianciulli +5 more
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Unconventional role of RAC1 in MET-driven anchorage-independent tumor growth
Molecular & Cellular Oncology, 2020 We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET.
Alexia Hervieu, Stéphanie Kermorgant
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