Results 51 to 60 of about 388,210 (312)

Supplemental Material, Ethical_review - miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway

, 2020
Supplemental Material, Ethical_review for miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway by Zhang Xuefang, Zheng Ruinian, Jiang Liji, Zhang Chun, Zheng Qiaolan, Jia Jun, Chen
Huang Junrong (8366229), Zheng Ruinian (8366214), Zhang Chun (4696399), Jiang Liji (8366217), Chen Yuming (8366226), Jia Jun (8366223), Zhang Xuefang (8366211), Zheng Qiaolan (8366220)   +7 more
core   +1 more source

Additional file 1 of Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis

, 2023
Additional file 1: Methods; Supplemetal Figure Legend; Table S1. The association between platelet count and homocysteine; Table S2. Characteristics of the study participants by quartailes of platelet count; Table S3.
Jing Nie (139250), Miaomiao Zhou (91821), Xiaomei Chen (406162), An Xiao (269214), Xianhui Qin (312737), Zhuoliang Liu (2315371), Liping Huang (315281), Zheng Hu (220019), Yiyue Zhang (3463826), Fengxin Zhu (772751), Zhiyuan Su (10021047), Wenjing Lei (772749), Panpan Meng (9112070), Junping Wang (397708), Chun Zhou (125722)   +14 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics [PDF]

Exploration of Drug Science
Aim: The PI3K (phosphoinositide 3-kinase)-alpha isoform is found upregulated in 30–40% of breast cancer. Currently, there are limited selective and specific drugs that target PI3K-alpha, and no natural therapeutic option is available.
Navya Aggarwal, Shinjini Sen, Banashree Bondhopadhyay   +2 more
doaj   +1 more source

Taurine Promotes Milk Synthesis via the GPR87-PI3K-SETD1A Signaling in BMECs

, 2019
Taurine, a β-aminosulfonic acid, exerts many cellular physiological functions. It is still unknown whether taurine can regulate milk synthesis in the mammary gland.
Xuejun Gao (591611), Yang Wang (5921), Yang Yu (4292), Zhe Wang (41178), Yanxu Liu (6310640), Mengmeng Yu (821140)   +5 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Corilagin inhibits angiotensin II-induced atrial fibrosis and fibrillation in mice through the PI3K-Akt pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Corilagin (Cor) is reported as beiing hepatoprotective, anti-inflammatory, antibacterial, and anti-oxidant, while the effect on atrial fibrosis remains unknown.
Xiaogang Zhang, Bei Tian, Xinpeng Cong, Zhongping Ning   +3 more
doaj   +1 more source

Oncogenic pathway driven by p85β: upstream signals to activate p110

Molecular & Cellular Oncology, 2020
The phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK).
Ling Rao, Lydia W. T. Cheung
doaj   +1 more source

Image_2_LncRNA NCAL1 potentiates natural killer cell cytotoxicity through the Gab2-PI3K-AKT pathway.tif

, 2022
Natural killer (NK) cells perform immune surveillance functions in tumors. The antitumor effects of NK cells are closely related to tumor occurrence and development.
Lei Zhou (19808), Min Li (12799), Yongchong Chen (10869756), Xiaoying Zhang (52883), Ji-fan Hu (13872578), Jiuwei Cui (558808), Xin Zhou (54275), Jianting Xu (4262554), Yufeng Wang (274657), Chao Niu (398203), Shan Zhu (211916), Zhaozhi Li (6206048)   +11 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source