Results 61 to 70 of about 390,020 (313)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Supplemental Material, Ethical_review - miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway

, 2020
Supplemental Material, Ethical_review for miR-331-3p Inhibits Proliferation and Promotes Apoptosis of Nasopharyngeal Carcinoma Cells by Targeting elf4B-PI3K-AKT Pathway by Zhang Xuefang, Zheng Ruinian, Jiang Liji, Zhang Chun, Zheng Qiaolan, Jia Jun, Chen
Huang Junrong (8366229), Zheng Ruinian (8366214), Zhang Chun (4696399), Jiang Liji (8366217), Chen Yuming (8366226), Jia Jun (8366223), Zhang Xuefang (8366211), Zheng Qiaolan (8366220)   +7 more
core   +1 more source

Additional file 1 of Hyperhomocysteinemia potentiates megakaryocyte differentiation and thrombopoiesis via GH-PI3K-Akt axis

, 2023
Additional file 1: Methods; Supplemetal Figure Legend; Table S1. The association between platelet count and homocysteine; Table S2. Characteristics of the study participants by quartailes of platelet count; Table S3.
Jing Nie (139250), Miaomiao Zhou (91821), Xiaomei Chen (406162), An Xiao (269214), Xianhui Qin (312737), Zhuoliang Liu (2315371), Liping Huang (315281), Zheng Hu (220019), Yiyue Zhang (3463826), Fengxin Zhu (772751), Zhiyuan Su (10021047), Wenjing Lei (772749), Panpan Meng (9112070), Junping Wang (397708), Chun Zhou (125722)   +14 more
core   +1 more source

Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics [PDF]

Exploration of Drug Science
Aim: The PI3K (phosphoinositide 3-kinase)-alpha isoform is found upregulated in 30–40% of breast cancer. Currently, there are limited selective and specific drugs that target PI3K-alpha, and no natural therapeutic option is available.
Navya Aggarwal, Shinjini Sen, Banashree Bondhopadhyay   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Taurine Promotes Milk Synthesis via the GPR87-PI3K-SETD1A Signaling in BMECs

, 2019
Taurine, a β-aminosulfonic acid, exerts many cellular physiological functions. It is still unknown whether taurine can regulate milk synthesis in the mammary gland.
Xuejun Gao (591611), Yang Wang (5921), Yang Yu (4292), Zhe Wang (41178), Yanxu Liu (6310640), Mengmeng Yu (821140)   +5 more
core   +1 more source

Corilagin inhibits angiotensin II-induced atrial fibrosis and fibrillation in mice through the PI3K-Akt pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Corilagin (Cor) is reported as beiing hepatoprotective, anti-inflammatory, antibacterial, and anti-oxidant, while the effect on atrial fibrosis remains unknown.
Xiaogang Zhang, Bei Tian, Xinpeng Cong, Zhongping Ning   +3 more
doaj   +1 more source

Oncogenic pathway driven by p85β: upstream signals to activate p110

Molecular & Cellular Oncology, 2020
The phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK).
Ling Rao, Lydia W. T. Cheung
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Image_2_LncRNA NCAL1 potentiates natural killer cell cytotoxicity through the Gab2-PI3K-AKT pathway.tif

, 2022
Natural killer (NK) cells perform immune surveillance functions in tumors. The antitumor effects of NK cells are closely related to tumor occurrence and development.
Lei Zhou (19808), Min Li (12799), Yongchong Chen (10869756), Xiaoying Zhang (52883), Ji-fan Hu (13872578), Jiuwei Cui (558808), Xin Zhou (54275), Jianting Xu (4262554), Yufeng Wang (274657), Chao Niu (398203), Shan Zhu (211916), Zhaozhi Li (6206048)   +11 more
core   +1 more source