Results 41 to 50 of about 18,384,661 (291)

Targeting PI3K in cancer: any good news?

Frontiers in Oncology, 2013
The phosphatidylinositol 3-kinase (PI3K) signaling pathway regulates several cellular processes and it’s one of the most frequently deregulated pathway in human tumors.
Miriam eMartini, Elisa eCiraolo, Federico eGulluni, Emilio eHirsch   +3 more
doaj   +1 more source

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
I. Mavrommati, Piñeiro R, Chiozzotto, D, Tania Maffucci, G. Tibolla, Pineiro, R, Wheeler Ann P., Giuseppe Danilo Norata (104795), Wheeler, A., Ioanna Mavrommati, Maffucci Tania, Norata, G., Chiozzotto Daniela, Ioanna Mavrommati (104788), Tibolla Gianpaolo, Mavrommati, I, Maffucci, T, D. Chiozzotto, Falasca, M, Mavrommati Ioanna, Alberico Luigi Catapano, Roberto Piñeiro (104782), Mavrommati, I., Daniela Chiozzotto, Ann P Wheeler, R. Piñeiro, Gianpaolo Tibolla (104779), Norata GD, G.D. Norata, Norata Giuseppe Danilo, M. Falasca, Giuseppe Danilo Norata, Daniela Chiozzotto (104784), T. Maffucci, Catapano AL, Ann P. Wheeler (104791), Falasca Marco, Piñeiro Roberto, A.L. Catapano, Marco Falasca (104805), Chiozzotto D, Alberico Luigi Catapano (104799), Falasca, Marco, Wheeler AP, Falasca M, Maffucci T, Catapano, A., Mavrommati I, Norata, GD, Tibolla G, Piñeiro, R., Chiozzotto, D., Marco Falasca, Maffucci, T., Tibolla, G., Tibolla, G, Wheeler, AP, Roberto Piñeiro, Catapano Alberico Luigi, A. P. Wheeler, Gianpaolo Tibolla, Catapano, AL, Tania Maffucci (104802)   +62 more
core   +1 more source

Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy

Acta Pharmaceutica Sinica B, 2017
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers. Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,
Wennan Zhao, Yuling Qiu, Dexin Kong
doaj   +1 more source

Regulation of T cell alloimmunity by PI3Kγ and PI3Kδ

Nature Communications, 2017
Phosphatidylinositol-3-kinases (PI3K) γ and δ are key regulators of T cell signaling. Here the author show, using mouse heart allograft transplantation models, that PI3Kγ or PI3Kδ deficiency prolongs graft survival, but selective inhibition of PI3Kγ or ...
Mayuko Uehara, Martina M. McGrath, Shunsuke Ohori, Zhabiz Solhjou, Naima Banouni, Sujit Routray, Catherine Evans, Jonathan P. DiNitto, Abdallah Elkhal, Laurence A. Turka, Terry B. Strom, Stefan G. Tullius, David G. Winkler, Jamil Azzi, Reza Abdi   +14 more
doaj   +1 more source

Calmodulin Activates Phosphatidylinositol 3-Kinase [PDF]

Journal of Biological Chemistry, 1997
Calmodulin and phosphatidylinositol 3-kinase are vital components of a number of common intracellular events. Calmodulin, a ubiquitous Ca2+-dependent effector protein, regulates multiple processes in eukaryotic cells, including cytoskeletal organization, vesicular trafficking, and mitogenesis.
J L, Joyal, D J, Burks, S, Pons, W F, Matter, C J, Vlahos, M F, White, D B, Sacks   +6 more
openaire   +2 more sources

The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila [PDF]

, 2008
Degradation of cytoplasmic components by autophagy requires the class III phosphatidylinositol 3 (PI(3)) – kinase Vps34, but the mechanisms by which this kinase and its lipid product PI(3) phosphate (PI(3)P) promote autophagy are unclear.
Backer, J. M., Baehrecke, EH, Miklós Sass, Hill, JH, Ying Yan, Hill, J. H., Sass, Miklós, Jahda H. Hill, Backer, JM, Gábor Juhász, Thomas P. Neufeld, Jonathan M. Backer, Baehrecke, E. H., Yan, Y, Neufeld, TP, Juhász, Gábor, Yan, Y., Neufeld, T. P., Eric H. Baehrecke   +18 more
core   +1 more source

The impact of PIK3CA mutations and PTEN expression on the effect of neoadjuvant therapy for postmenopausal luminal breast cancer patients

BMC Cancer, 2023
Background There is pressing needs to find the biomarker in the selection of neoadjuvant therapy in postmenopausal luminal breast cancer patients. We examined the hypothesis that PIK3CA mutations and low phosphatase and tensin homolog (PTEN) expression ...
Shouko Hayama, Rikiya Nakamura, Takayuki Ishige, Takafumi Sangai, Masahiro Sakakibara, Hiroshi Fujimoto, Emi Ishigami, Takahito Masuda, Ayako Nakagawa, Ryotaro Teranaka, Satoshi Ota, Sakae Itoga, Naohito Yamamoto, Takeshi Nagashima, Masayuki Otsuka   +14 more
doaj   +1 more source

Is wortmannin-induced reorganization of the trans-Golgi network the key to explain charasome formation?

Frontiers in Plant Science, 2016
Wortmannin, a fungal metabolite and an inhibitor of phosphatidylinositol-3 (PI3) and phosphatidylinositol-4 (PI4) kinases, is widely used for the investigation and dissection of vacuolar trafficking routes and for the identification of proteins located ...
Ilse eFoissner, Aniela eSommer, Margit eHoeftberger, Marion Christine Hoepflinger, Marketa eAbsolonova   +4 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Establishment of a structure-activity relationship of the 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness [PDF]

, 2014
The compound NVP-BEZ235 (1) is a potent inhibitor of human phospoinositide-3-kinases (PI3Ks) and mammalian target of rapamycin (mTOR) that also showed high inhibitory potency against T. brucei cultures. With an eye towards using 1 as a starting point for
Pollastri, Michael P, Smith, Terry K, Berlanga, Manuela, Luengo-Arratta, Sandra A, Rojas-Barros, Domingo I, Saldivia, Manuel, Diaz, Rosario, Gonzalez, Silvia, Seixas, João D, Manzano, Pilar, Navarro, Miguel   +10 more
core   +1 more source