Results 31 to 40 of about 18,384,661 (291)

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase [PDF]

, 2014
The Vps34 (vacuolar protein sorting 34) class III PI3K (phosphoinositide 3-kinase) phosphorylates PtdIns (phosphatidylinositol) at endosomal membranes to generate PtdIns(3)P that regulates membrane trafficking processes via its ability to recruit a ...
Ward, Richard, Davies, Paul; id_orcid, Bago, Ruzica, Shpiro, Natalia, Cross, Darren, Sommer, Eeva, Malik, Nazma, Ganley, Ian G.; id_orcid, Munson, Michael J., Alessi, Dario R.; id_orcid, Prescott, Alan R.; id_orcid   +10 more
core   +1 more source

PI3K pathway in NSCLC

Frontiers in Oncology, 2012
The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of intracellular lipid kinases that phosphorylate the 3’-hydroxyl group of phosphatidylinositol and phosphoinositides.
Alex eMartínez Martí, Enriqueta eFelip
doaj   +1 more source

Phosphatidylinositol 3-monophosphate is involved in Toxoplasma apicoplast biogenesis [PDF]

, 2011
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Henri J Vial, Dubremetz, J.-F., Payrastre, B., Merezegue, F., Montcourrier, Philippe, Merezegue, Fabrice, Jean-François Dubremetz, Tawk, Lina, Payrastre Bernard, Chicanne Gaëtan, Payrastre, Bernard, Roy Christian, Philippe Montcourrier, Lebrun Maryse, Vial, H.J., Vial Henri J., Véronique Richard, Henri J. Vial, Roy, C., Dubremetz Jean-François, Markus Meissner, Lebrun, M., Chicanne, G., Kai Wengelnik, Wengelnik Kai, Christian Roy, Wengelnik, Kai, Lina Tawk, Chicanne, Gaëtan, Montcourrier Philippe, Lebrun, Maryse, Bernard Payrastre, Vial, Henri, Roy, Christian, Fabrice Merezegue, Richard, V., Meissner, M., Meissner Markus, Richard Véronique, Tawk, L., Meissner, Markus, Gaëtan Chicanne, Maryse Lebrun, Tawk Lina, Merezegue Fabrice, Dubremetz, Jean-François, Wengelnik, K., Montcourrier, P., Richard, Véronique   +48 more
core   +2 more sources

Molecular Docking and Molecular Dynamics Simulation Studies of Quinoline-3-Carboxamide Derivatives with DDR Kinases–Selectivity Studies towards ATM Kinase

Chemistry, 2021
Quinoline-3-carboxamides are an essential class of drug-like small molecules that are known to inhibit the phosphatidylinositol 3-kinase-related kinases (PIKK) family kinases.
Srimadhavi Ravi, Bhanu Priya, Pankaj Dubey, Vijay Thiruvenkatam, Sivapriya Kirubakaran   +4 more
doaj   +1 more source

Exploring the potential of AgNPs in modulating the PI3K/AKT/mTOR pathway via miR-133a regulation in MCF-7 breast cancer cells [PDF]

Nanomedicine Journal
Objective(s): Breast cancer is the most common malignancy in women. MiRNAs modulate the PI3K/AKT/mTOR (PAM) pathway, functioning as either tumor suppressors or oncogenes. This research explores the impact of AgNPs on breast cancer cells while emphasizing
Mohammadjavad Hossein Tehrani, Nasrin Ziamajidi, Roghayeh Abbasalipourkabir, Zeinab Barartabar, Somayeh Aslani   +4 more
doaj   +1 more source

α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

eLife, 2021
The Parkinson’s disease protein α-synuclein (αSyn) promotes membrane fusion and fission by interacting with various negatively charged phospholipids. Despite postulated roles in endocytosis and exocytosis, plasma membrane (PM) interactions of αSyn are ...
Reeba Susan Jacob, Cédric Eichmann, Alessandro Dema, Davide Mercadante, Philipp Selenko   +4 more
doaj   +1 more source

Association of Genetic Variations in The PIK3-AKT-mTOR Pathway with Endometriosis Susceptibility: A Preliminary Case-Control Study [PDF]

International Journal of Fertility and Sterility
Background: Endometriosis is a complex, heterogeneous disease with several genetic and non-genetic pathogenic fac­tors. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway may influence both ...
Rahele Ghasemian Moghadam, Forough Forghani, Danial Jahantigh, Saeedeh Ghazaey Zidanloo, Mahnaz Rezaei, Mohsen Taheri   +5 more
doaj   +1 more source

Inhibition of PI3K/Akt signaling suppresses epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway [PDF]

Clinical and Molecular Hepatology, 2020
Background/Aims Patients with advanced hepatocellular carcinoma (HCC) have a poor prognosis due to the lack of effective systemic therapies. Epithelial-to-mesenchymal transition (EMT) is a pivotal event in tumor progression, during which cancer cells ...
Seulki Lee, Eun Ji Choi, Eun Ju Cho, Yun Bin Lee, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim   +7 more
doaj   +1 more source

Phosphatidylinositol 3-Kinase [PDF]

Circulation Research, 2002
The pathogenesis of essential hypertension is multifactorial. Although the cause of elevated arterial pressure is unknown in most cases, the fundamental hemodynamic abnormality in hypertension is increased peripheral resistance primarily due to changes in vascular structure and function.1 These changes include arterial wall thickening and abnormal ...
Masataka, Sata, Ryozo, Nagai
openaire   +2 more sources

The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics

Scientific Reports, 2023
Phosphatidylinositol (3,4,5) trisphosphate (PIP3) is a plasma membrane-bound signaling phospholipid involved in many cellular signaling pathways that control crucial cellular processes and behaviors, including cytoskeleton remodeling, metabolism ...
Dhanushan Wijayaratna, Kasun Ratnayake, Sithurandi Ubeysinghe, Dinesh Kankanamge, Mithila Tennakoon, Ajith Karunarathne   +5 more
doaj   +1 more source