Results 41 to 50 of about 27,020 (299)

Phosphoinositide-signaling is one component of a robust plant defense response.

Frontiers in Plant Science, 2014
The phosphoinositide pathway and inositol-1,4,5-triphosphate (InsP3) have been implicated in plant responses to many abiotic stresses; however, their role in response to biotic stress is not well characterized.
Imara Yasmin Perera, Chiu-Yueh eHung, Peter eAspesi Jr, Melissa R Hunter, Aaron eLomax   +4 more
doaj   +1 more source

So far, yet so close: α-Catenin dimers help migrating cells get together [PDF]

, 2017
Epithelial cells in tissues use their actin cytoskeletons to stick together, whereas unattached cells make active plasma membrane protrusions to migrate. In this issue, Wood et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201612006) show that the
Benjamin, Braga, Chinthalapudi, Drees, Edwards, Hansen, Klezovitch, Laura Machesky, Lien, Shewan, Vania M.M. Braga, Vasioukhin, Wood   +12 more
core   +2 more sources

Taurine Attenuates Streptococcus uberis-Induced Bovine Mammary Epithelial Cells Inflammation via Phosphoinositides/Ca2+ Signaling

Frontiers in Immunology, 2019
Taurine may alleviate the inflammatory injury induced by Streptococcus uberis (S. uberis) infection by regulating intracellular Ca2+ levels. However, the underlying mechanisms remain unclear. Infection leads to subversion of phosphoinositides (PIs) which
Ming Li, Panpan Xi, Yuanyuan Xu, Zhenglei Wang, Xiangan Han, Wenkai Ren, Vanhnaseng Phouthapane, Jinfeng Miao   +7 more
doaj   +1 more source

Structure of the full-length TRPV2 channel by cryo-EM. [PDF]

, 2016
Transient receptor potential (TRP) proteins form a superfamily Ca(2+)-permeable cation channels regulated by a range of chemical and physical stimuli. Structural analysis of a 'minimal' TRP vanilloid subtype 1 (TRPV1) elucidated a mechanism of channel ...
Cohen, Matthew R, Huynh, Kevin W, Jiang, Jiansen, Lodowski, David T, Moiseenkova-Bell, Vera Y, Samanta, Amrita, Zhou, Z Hong   +6 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids [PDF]

, 2016
Inward rectifier potassium (Kir) channel activity is controlled by plasma membrane lipids. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) binding to a primary site is required for opening of classic inward rectifier Kir2.1 and Kir2.2 channels, but ...
Anna Stary-Weinzinger, Aryal, Berendsen, Berger, Braun, Chen, Cheng, Colin G. Nichols, Cordomí, Darden, D’Avanzo, D’Avanzo, D’Avanzo, Emsley, Enkvetchakul, Eva-Maria Zangerl-Plessl, Feifei Ren, Hansen, Hess, Hess, Hibino, Hilgemann, Ho, Hoover, Hornak, Ingólfsson, Jiang, Joung, Killian, Koster, Lee, Linder, Lopes, Mase, McCusker, Murshudov, Nichols, Nosé, Parrinello, Peng Yuan, Pratt, Proks, Rohács, Sarah Heyman, Sun-Joo Lee, Tao, Vagin, van Meer, Wallin, Whorton, Whorton, Wimley, Winn, Wolf, Yau, Yokogawa   +55 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

How PI3K-derived lipids control cell division

Frontiers in Cell and Developmental Biology, 2015
To succeed in cell division, intense cytoskeletal and membrane remodeling are required to allow accurate chromosome segregation and cytoplasm partitioning.
Carlo Cosimo Campa, Miriam eMartini, Maria Chiara eDe Santis, Emilio eHirsch   +3 more
doaj   +1 more source

Changes in membrane lipids drive increased endocytosis following Fas ligation [PDF]

, 2017
Once activated, some surface receptors promote membrane movements that open new portals of endocytosis, in part to facilitate the internalization of their activated complexes.
Degli Esposti, Mauro, Garofalo, Tina, Khosravi Far, Roya, Longo, Agostina, Malorni, Walter, Matarrese, Paola, Misasi, Roberta, Recalchi, Serena, Sorice, Maurizio, Tinari, Antonella   +9 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source