Structural mechanism of SAM-AMP and SAM-AMP2 synthesis by the type III-D2 CRISPR effector complex [PDF]
Nature CommunicationsThe type III-D2 CRISPR-Cas system comprises multiple Cas subunits and a CRISPR RNA, and is likely an evolutionary intermediate between the well-studied type III-A and III-E systems.
Yoshihisa Mitsuda +11 more
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Network-level divergence in cyclic di-GMP signalling drives ecological versatility in Acinetobacter baumannii [PDF]
npj Biofilms and MicrobiomesSecond messenger signalling pathways are known to play a fundamental role in governing bacterial physiology and mediating rapid adaptive responses to stimuli.
Rubén de Dios +12 more
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Extracellular cGAMP in health and disease [PDF]
Molecular BiomedicineThe cGAS-STING signaling pathway is a crucial component of the innate immune system that detects aberrant cytosolic DNA, such as that derived from viruses or damaged cells, to activate downstream immune responses.
Zhongling Dai +5 more
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Second messenger systems in Tourette's syndrome
Journal of the Neurological Sciences, 1995 Abnormalities within second messenger systems have been hypothesized as the underlying pathophysiologic mechanism in a variety of neuropsychiatric disorders. In the Gilles de la Tourette syndrome (TS) prior studies have shown that the concentration of adenosine 3',5'-monophosphate (cAMP) is reduced in cortical and putamen brain regions.
H S Singer
exaly +3 more sources
Second messenger systems and adaptation. [PDF]
Gut, 1987 Adaptive changes represent shifts in the equilibrium state of biologic systems in reponse to long standing alterations in their surrounding environment. Adaptation encompasses a variety of cellular changes ranging from very specific responses, such as variation in the production of a single protein, to broader responses including alterations in the ...
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New Journal of Physics, 2021 We consider a sequential cascade of molecular first-reaction events towards a terminal reaction centre in which each reaction step is controlled by diffusive motion of the particles.
Denis S Grebenkov +2 more
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Pancreatic Beta Cell G-Protein Coupled Receptors and Second Messenger Interactions: A Systems Biology Computational Analysis. [PDF]
PLoS ONE, 2016 Insulin secretory in pancreatic beta-cells responses to nutrient stimuli and hormonal modulators include multiple messengers and signaling pathways with complex interdependencies.
Leonid E Fridlyand, Louis H Philipson
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Bipolar Disorder and Obsessive Compulsive Disorder Comorbidity [PDF]
Psikiyatride Güncel Yaklaşımlar, 2014 The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients.
Necla Keskin, Lut Tamam
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Water-soluble cranberry extract inhibits Vibrio cholerae biofilm formation possibly through modulating the second messenger 3', 5' - Cyclic diguanylate level. [PDF]
PLoS ONE, 2018 Quorum sensing (QS) and nucleotide-based second messengers are vital signaling systems that regulate bacterial physiology in response to changing environments.
Daniel B Pederson +4 more
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Arsenic Trioxide Modulates the Central Snail Neuron Action Potential
Journal of the Formosan Medical Association, 2009 The electropharmacological effect of arsenic trioxide (As2O3) is unknown. The present study investigated the effects of As2O3 on spontaneous neuronal impulse activity. Methods: Intracellular recordings and the two-electrode voltage clamp method were used
Guan-Ling Lu +4 more
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