Results 1 to 10 of about 2,212 (248)
Reactive oxygen species in disease: Rebuttal of a conventional concept
Journal of Controversies in Biomedical Research, 2015 The production of intracellular reactive oxygen species and reactive nitrogen species has long been proposed as leading to the random deleterious modification of macromolecules (i.e., nucleic acids, proteins) with an associated progressive development of
Luis Vitetta +2 more
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Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System
Frontiers in Systems Neuroscience, 2022 Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
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Information Content in Stochastic Pulse Sequences of Intracellular Messengers
Frontiers in Physics, 2018 Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of ...
Alan Givré +3 more
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Physiological Sensing of Carbon Dioxide/Bicarbonate/pH via Cyclic Nucleotide Signaling
Sensors, 2011 Carbon dioxide (CO2) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO2 is unequivocally linked with bicarbonate (HCO3−) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are
Lonny R. Levin, Jochen Buck
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Brazilian Journal of Psychiatry, 2004 OBJETIVOS: Estudos pós-mortem, farmacológicos, de neuroimagem e em modelos animais têm demonstrado uma possível associação de mecanismos de sinalização intracelular na fisiopatologia do transtorno afetivo bipolar (TAB).
Benício Noronha Frey +4 more
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Regulation of poly-GlcNAc expression and fimbriation in uropathogenic "E. coli" [PDF]
, 2013 The transition of planktonic to sessile lifestyles in bacteria rests upon a tightly controlled program that gets triggered by the environmental composition and whose implementation requires multiple feedback controls. Uropathogenic E.
Hosch, Lucie
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Luciferase complementation based-detection of G-protein-coupled receptor activity
BioTechniques, 2018 Protein complementation assays (PCA) are used as pharmacological tools, enabling a wide array of applications, ranging from studies of protein–protein interactions to second messenger effects.
Hideaki Yano +3 more
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Ecotoxicology and Environmental Safety, 2021 Studies about radiation damage in vivo are very significant for healthy risk assessment as well as cancer radiotherapy. Ceramide as a second messenger has been found to be related to radiation-induced apoptosis. However, the detailed mechanisms in living
Yaning Yang +6 more
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The period circadian clock 2 gene responds to glucocorticoids and regulates osteogenic capacity
Regenerative Therapy, 2019 Introduction: The central regulatory system that generates biological rhythms is regulated by circadian clock genes expressed by cells in the suprachiasmatic nucleus.
Takahiro Abe +3 more
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LytTR Regulatory Systems: A potential new class of prokaryotic sensory system. [PDF]
PLoS Genetics, 2018 The most commonly studied prokaryotic sensory signal transduction systems include the one-component systems, phosphosignaling systems, extracytoplasmic function (ECF) sigma factor systems, and the various types of second messenger systems.
Zhengzhong Zou +8 more
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