Results 11 to 20 of about 128,438 (257)
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: The goal of this proposal is to develop a technology that combines calcium imaging via confocal microscopy, and force measurement via monolayer stress microscopy to perform simultaneous quantitative measurements of agonist-induced Ca2 ...
Santina Johnson +9 more
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Artificial Signal Transduction
ChemistryOpen, 2020 Communication between and inside cells as well as their response to external stimuli relies on elaborated systems of signal transduction. They all require a directional transmission across membranes, often realized by primary messenger docking onto ...
Robert Bekus, Prof. Thomas Schrader
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Biological Research, 2004 Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems.
EDUARDO NUNES CHINI
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The Multiple Regulatory Relationship Between RNA-Chaperone Hfq and the Second Messenger c-di-GMP
Frontiers in Microbiology, 2021 RNA chaperone protein Hfq is an important post-transcriptional regulator in bacteria, while c-di-GMP is a second messenger signaling molecule widely distributed in bacteria.
Yang Fu +9 more
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Second Messenger Systems in Human Gliomas
Archives of Pathology & Laboratory Medicine, 2007 Abstract Context. —Patients with glioblastoma (astrocytoma, World Health Organization grade IV) exhibit 2-year survival rates of less than 20% despite significant advances in therapeutic options available to patients.
Roger E, McLendon +3 more
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Nuclear expression of diacylglycerol kinases: possible involvement in DNA replication
European Journal of Histochemistry, 2009 The existence of intranuclear lipid-dependent signal transduction systems has been demonstrated by several independent groups. Remarkably, intranuclear lipid-dependent signal transduction pathways are regulated independently from their membrane/cytosolic
C Evangelisti +5 more
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Frontiers in Physiology, 2013 Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signalling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the ...
Verónica Celeste De Giusti +5 more
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Reactive oxygen species in disease: Rebuttal of a conventional concept
Journal of Controversies in Biomedical Research, 2015 The production of intracellular reactive oxygen species and reactive nitrogen species has long been proposed as leading to the random deleterious modification of macromolecules (i.e., nucleic acids, proteins) with an associated progressive development of
Luis Vitetta +2 more
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Cellular Tolerance Induced by Chronic Opioids in the Central Nervous System
Frontiers in Systems Neuroscience, 2022 Opioids are powerful analgesics that elicit acute antinociceptive effects through their action the mu opioid receptor (MOR). However opioids are ineffective for chronic pain management, in part because continuous activation of MORs induces adaptive ...
Sweta Adhikary, John T. Williams
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Information Content in Stochastic Pulse Sequences of Intracellular Messengers
Frontiers in Physics, 2018 Many cell signaling pathways rely on oscillatory messenger concentrations even to transduce aperiodic environmental changes. The universal second messenger calcium, Ca2+ often exhibits pulsatile behavior in the presence of constant concentrations of ...
Alan Givré +3 more
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