Results 1 to 10 of about 17,904 (252)

c-di-GMP Inhibits Early Sporulation in Clostridioides difficile [PDF]

mSphere, 2021
The formation of dormant spores is essential for the anaerobic pathogen Clostridioides difficile to survive outside the host gastrointestinal tract. The regulatory pathways and environmental signals that initiate C.
Adrianne N. Edwards, Caitlin L. Willams, Nivedita Pareek, Shonna M. McBride, Rita Tamayo   +4 more
doaj   +3 more sources

c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR [PDF]

mBio
As a near-ubiquitous bacterial second messenger, cyclic di-GMP (c-di-GMP) regulates a multitude of important biological processes. The regulatory effects of c-di-GMP on bacterial physiological processes are mediated through its interaction with various ...
Lianying Mao, Jialin Li, Xinyi Huo, Wenguang Yang, Heng Zhang, Chongyi Duan, Xihui Shen, Lei Zhang   +7 more
doaj   +2 more sources

Toolbox of FRET-based c-di-GMP biosensors and its FRET-To-Sort application for genome-wide mapping of c-di-GMP regulation [PDF]

Nature Communications
C-di-GMP is a widespread second messenger that coordinates transitions between different lifestyles in bacteria. Levels of c-di-GMP are controlled by complex regulatory networks, and they can vary dynamically over a wide range of concentrations.
Liyun Wang, Gabriele Malengo, Ananda Sanches-Medeiros, Xuanlin Chen, Julian Pietsch, Nataliya Teteneva, Silvia González Sierra, Ming C. Hammond, Victor Sourjik   +8 more
doaj   +2 more sources

Identification and Characterization of c-di-GMP Metabolic Enzymes of Leptospira interrogans and c-di-GMP Fluctuations After Thermal Shift and Infection [PDF]

Frontiers in Microbiology, 2018
Leptospirosis is a widespread zoonotic disease caused by pathogenic Leptospira species. The most common species, Leptospira interrogans, can transfer from contaminated soil or water to the human body.
Guohui Xiao, Liangliang Kong, Liangliang Kong, Rongbo Che, Yusi Yi, Qinchao Zhang, Jie Yan, Jie Yan, Xu'ai Lin, Xu'ai Lin   +9 more
doaj   +3 more sources

Reduced Intracellular c-di-GMP Content Increases Expression of Quorum Sensing-Regulated Genes in Pseudomonas aeruginosa

Frontiers in Cellular and Infection Microbiology, 2017
Cyclic-di-GMP (c-di-GMP) is an intracellular secondary messenger which controls the biofilm life cycle in many bacterial species. High intracellular c-di-GMP content enhances biofilm formation via the reduction of motility and production of biofilm ...
Song Lin Chua, Sylvia Yang Liu, Gurjeet S Kohli   +2 more
exaly   +3 more sources

Low levels of the second messenger c-di-GMP enhance tolerance and resistance to meropenem in Pseudomonas aeruginosa [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundThe carbapenem antibiotic meropenem is often used to treat life-threatening infections caused by Pseudomonas aeruginosa. Previous studies have shown that the susceptibility of P.
Tarcisio Brignoli, Silvia Ferrara, Silvia Ferrara, Edoardo Labrini, Giovanni Bertoni   +4 more
doaj   +2 more sources

A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli [PDF]

Frontiers in Chemistry
Cyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence.
He Li, Shu Quan, Shu Quan, Wei He, Wei He   +4 more
doaj   +2 more sources

Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors [PDF]

Biomolecules
Cyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia, Ge Yun, Bingxin Liu, Xinxin Li, Meiling Jiang, Xinlu Yu, Jing Zhang, Yufei Han, Dan Liu, Junlong Zhao, Yuanyuan Wang, Gukui Chen   +11 more
doaj   +2 more sources

The global regulation of c-di-GMP and cAMP in bacteria. [PDF]

mLife
AbstractNucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria. The best‐studied examples are cyclic AMP (cAMP) and bis‐(3′–5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP), which both act as global regulators.
Liu C, Shi R, Jensen MS, Zhu J, Liu J, Liu X, Sun D, Liu W.   +7 more
europepmc   +4 more sources

Gas and light: triggers of c-di-GMP-mediated regulation

FEMS Microbiology Reviews, 2023
AbstractThe widespread bacterial second messenger c-di-GMP is responsible for regulating many important physiological functions such as biofilm formation, motility, cell differentiation, and virulence. The synthesis and degradation of c-di-GMP in bacterial cells depend, respectively, on diguanylate cyclases and c-di-GMP-specific phosphodiesterases ...
He Yang, Shan-Ho Chou, Michael Y Galperín   +2 more
exaly   +3 more sources