Results 1 to 10 of about 18,741 (111)

A dual-threshold system relying on multiple c-di-GMP metabolic enzymes controls cell fate of a cyanobacterium. [PDF]

PLoS Biology
Cyclic-di-GMP (c-di-GMP) is a ubiquitous second messenger in bacteria and regulates a variety of cell activities. Many bacteria contain multiple enzymes involved in c-di-GMP synthesis or degradation; however, how they coordinate with each other to ...
Qing-Xue Sun, Min Huang, Yiling Yang, Xiaoli Zeng, Cheng-Cai Zhang   +4 more
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c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR [PDF]

mBio
As a near-ubiquitous bacterial second messenger, cyclic di-GMP (c-di-GMP) regulates a multitude of important biological processes. The regulatory effects of c-di-GMP on bacterial physiological processes are mediated through its interaction with various ...
Lianying Mao, Jialin Li, Xinyi Huo, Wenguang Yang, Heng Zhang, Chongyi Duan, Xihui Shen, Lei Zhang   +7 more
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Toolbox of FRET-based c-di-GMP biosensors and its FRET-To-Sort application for genome-wide mapping of c-di-GMP regulation [PDF]

Nature Communications
C-di-GMP is a widespread second messenger that coordinates transitions between different lifestyles in bacteria. Levels of c-di-GMP are controlled by complex regulatory networks, and they can vary dynamically over a wide range of concentrations.
Liyun Wang, Gabriele Malengo, Ananda Sanches-Medeiros, Xuanlin Chen, Julian Pietsch, Nataliya Teteneva, Silvia González Sierra, Ming C. Hammond, Victor Sourjik   +8 more
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Low levels of the second messenger c-di-GMP enhance tolerance and resistance to meropenem in Pseudomonas aeruginosa [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundThe carbapenem antibiotic meropenem is often used to treat life-threatening infections caused by Pseudomonas aeruginosa. Previous studies have shown that the susceptibility of P.
Tarcisio Brignoli, Silvia Ferrara, Silvia Ferrara, Edoardo Labrini, Giovanni Bertoni   +4 more
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A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli [PDF]

Frontiers in Chemistry
Cyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence.
He Li, Shu Quan, Shu Quan, Wei He, Wei He   +4 more
doaj   +2 more sources

Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors [PDF]

Biomolecules
Cyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia, Ge Yun, Bingxin Liu, Xinxin Li, Meiling Jiang, Xinlu Yu, Jing Zhang, Yufei Han, Dan Liu, Junlong Zhao, Yuanyuan Wang, Gukui Chen   +11 more
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c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin [PDF]

EMBO Reports
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE.
Siqi Yu, Zheyao Hu, Xiaoting Xu, Xiaoran Liang, Jiayi Shen, Min Liu, Mingxi Lin, Hong Chen, Jordi Marti, Sheng-ce Tao, Zhaowei Xu   +10 more
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AphA-dependent c-di-GMP production in Vibrio parahaemolyticus is mediated by direct regulation of eapA transcription encoding an EAL domain-containing protein [PDF]

Journal of Bacteriology
Vibrio parahaemolyticus, a major seafood-borne pathogen, employs quorum sensing (QS) and c-di-GMP to regulate virulence, motility, and biofilm formation.
Nan Zhang, Wu Xu, Xue Li, Miaomiao Zhang, Xi Luo, Bin Ni, Renfei Lu, Yiquan Zhang   +7 more
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A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP [PDF]

Nature Communications
Cyclic diguanosine monophosphate (c-di-GMP) functions as a crucial bacterial second messenger to control diverse biological functions. Although numerous studies have reported the health effects of Lactiplantibacillus plantarum, the regulatory role of c ...
Quan Guo, Guangqiang Wang, Leijie Zheng, Hui Xue, Ruimin Wang, Yajing Fang, Jiachao Zhang   +6 more
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Bi-modal distribution of the second messenger c-di-GMP controls cell fate and asymmetry during the caulobacter cell cycle. [PDF]

PLoS Genetics, 2013
Many bacteria mediate important life-style decisions by varying levels of the second messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular processes such as motility, surface adherence or the production of virulence ...
Sören Abel, Tabitha Bucher, Micaël Nicollier, Isabelle Hug, Volkhard Kaever, Pia Abel Zur Wiesch, Urs Jenal   +6 more
doaj   +1 more source