Results 1 to 10 of about 24,065 (296)

c-di-GMP regulates bacterial NAD biosynthesis via targeting the transcriptional repressor NadR [PDF]

mBio
As a near-ubiquitous bacterial second messenger, cyclic di-GMP (c-di-GMP) regulates a multitude of important biological processes. The regulatory effects of c-di-GMP on bacterial physiological processes are mediated through its interaction with various ...
Lianying Mao, Jialin Li, Xinyi Huo, Wenguang Yang, Heng Zhang, Chongyi Duan, Xihui Shen, Lei Zhang   +7 more
doaj   +2 more sources

Cyclic di-GMP: second messenger extraordinaire [PDF]

Nature Reviews Microbiology, 2017
Cyclic dinucleotides (CDNs) are highly versatile signalling molecules that control various important biological processes in bacteria. The best-studied example is cyclic di-GMP (c-di-GMP).
Urs Jenal
exaly   +3 more sources

Toolbox of FRET-based c-di-GMP biosensors and its FRET-To-Sort application for genome-wide mapping of c-di-GMP regulation [PDF]

Nature Communications
C-di-GMP is a widespread second messenger that coordinates transitions between different lifestyles in bacteria. Levels of c-di-GMP are controlled by complex regulatory networks, and they can vary dynamically over a wide range of concentrations.
Liyun Wang, Gabriele Malengo, Ananda Sanches-Medeiros, Xuanlin Chen, Julian Pietsch, Nataliya Teteneva, Silvia González Sierra, Ming C. Hammond, Victor Sourjik   +8 more
doaj   +2 more sources

The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi [PDF]

Frontiers in Cellular and Infection Microbiology, 2014
In nature, the Lyme disease spirochete Borrelia burgdorferi cycles between the unrelated environments of the Ixodes tick vector and mammalian host. In order to survive transmission between hosts, B.
Elizabeth A. Novak, Syed Z. Sultan, Md. A. Motaleb   +2 more
doaj   +4 more sources

Low levels of the second messenger c-di-GMP enhance tolerance and resistance to meropenem in Pseudomonas aeruginosa [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundThe carbapenem antibiotic meropenem is often used to treat life-threatening infections caused by Pseudomonas aeruginosa. Previous studies have shown that the susceptibility of P.
Tarcisio Brignoli, Silvia Ferrara, Silvia Ferrara, Edoardo Labrini, Giovanni Bertoni   +4 more
doaj   +2 more sources

A genetically encoded fluorescent biosensor for sensitive detection of cellular c-di-GMP levels in Escherichia coli [PDF]

Frontiers in Chemistry
Cyclic di-guanosine monophosphate (c-di-GMP) acts as a second messenger regulating bacterial behaviors including cell cycling, biofilm formation, adhesion, and virulence.
He Li, Shu Quan, Shu Quan, Wei He, Wei He   +4 more
doaj   +2 more sources

Dynamic Executors of Bacterial Signals: Functional Versatility and Regulatory Networks of c-di-GMP Effectors [PDF]

Biomolecules
Cyclic di-GMP (c-di-GMP), a universal second messenger in bacteria, orchestrates a wide array of essential life processes. Its intracellular dynamics are meticulously regulated by diguanylate cyclases (DGCs) and phosphodiesterases (PDEs), ensuring ...
Jia Jia, Ge Yun, Bingxin Liu, Xinxin Li, Meiling Jiang, Xinlu Yu, Jing Zhang, Yufei Han, Dan Liu, Junlong Zhao, Yuanyuan Wang, Gukui Chen   +11 more
doaj   +2 more sources

c-di-GMP inhibits rRNA methylation and impairs ribosome assembly in the presence of kanamycin [PDF]

EMBO Reports
Cyclic diguanosine monophosphate (c-di-GMP) is a ubiquitous bacterial secondary messenger with diverse functions. A previous Escherichia coli proteome microarray identified that c-di-GMP binds to the 23S rRNA methyltransferases RlmI and RlmE.
Siqi Yu, Zheyao Hu, Xiaoting Xu, Xiaoran Liang, Jiayi Shen, Min Liu, Mingxi Lin, Hong Chen, Jordi Marti, Sheng-ce Tao, Zhaowei Xu   +10 more
doaj   +2 more sources

AphA-dependent c-di-GMP production in Vibrio parahaemolyticus is mediated by direct regulation of eapA transcription encoding an EAL domain-containing protein [PDF]

Journal of Bacteriology
Vibrio parahaemolyticus, a major seafood-borne pathogen, employs quorum sensing (QS) and c-di-GMP to regulate virulence, motility, and biofilm formation.
Nan Zhang, Wu Xu, Xue Li, Miaomiao Zhang, Xi Luo, Bin Ni, Renfei Lu, Yiquan Zhang   +7 more
doaj   +2 more sources

A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP [PDF]

Nature Communications
Cyclic diguanosine monophosphate (c-di-GMP) functions as a crucial bacterial second messenger to control diverse biological functions. Although numerous studies have reported the health effects of Lactiplantibacillus plantarum, the regulatory role of c ...
Quan Guo, Guangqiang Wang, Leijie Zheng, Hui Xue, Ruimin Wang, Yajing Fang, Jiachao Zhang   +6 more
doaj   +2 more sources