Results 21 to 30 of about 24,065 (296)

Protein Deacetylase CobB Interplays with c-di-GMP [PDF]

SSRN Electronic Journal, 2018
AbstractAs a ubiquitous bacterial secondary messenger, c-di-GMP plays key regulatory roles in processes such as bacterial motility and transcription regulation. CobB is the Sir2 family protein deacetylase that controls energy metabolism, chemotaxis and DNA supercoiling in many bacteria. Using anE.coliproteome microarray, we found that c-di-GMP strongly
Xu, Zhaowei, Zhang, Hainan, Zhang, Xingrun, Liu, Chengxi, Jiang, Hewei, Wu, Fanlin, Qian, Lili, Czajkowsky, Daniel M., Guo, Shujuan, Bi, Lijun, Wang, Shihua, Li, Haitao, Tan, Minjia, Feng, Lei, Hou, Jingli, Tao, Sheng-ce   +15 more
openaire   +1 more source

Identification of Cyclic-di-GMP-Modulating Protein Residues by Bidirectionally Evolving a Social Behavior in Pseudomonas fluorescens

mSystems, 2022
Modulation of the intracellular cyclic di-GMP (c-di-GMP) pool is central to the formation of structured bacterial communities. Genome annotations predict the presence of dozens of conserved c-di-GMP catalytic enzymes in many bacterial species, but the ...
Collin Kessler, Wook Kim
doaj   +1 more source

A Minimal Threshold of c-di-GMP Is Essential for Fruiting Body Formation and Sporulation in Myxococcus xanthus [PDF]

, 2016
Generally, the second messenger bis-(3’-5’)-cyclic dimeric GMP (c-di-GMP) regulates the switch between motile and sessile lifestyles in bacteria. Here, we show that c-di-GMP is an essential regulator of multicellular development in the social bacterium ...
A Duerig, A Konovalova, A Lu, AJ Schmidt, B Julien, BK Bharati, BY Chang, BY Matsuyama, BZ Harris, C Baraquet, C Spangler, CD Boyd, D Amikam, D Kaiser, D Skotnicka, D Srivastava, DA Ryjenkov, DA Ryjenkov, Dorota Skotnicka, E Bordeleau, E Trampari, Eleftheria Trampari, Gregory T. Smaldone, H Lancero, I Bulyha, I Letunic, IS Pultz, J Hodgkin, J Hodgkin, J Sambrook, Jacob G. Malone, Jennifer Liang, JJ Wilksch, Josep Casadesús, JP Massie, JT Pratt, JW Hickman, JW Hickman, KG Roelofs, KH Chin, L Hobley, L Jelsbak, L Søgaard-Andersen, LJ Shimkets, Lotte Søgaard-Andersen, M Christen, M Christen, M Fazli, M Merighi, M Overgaard, M Singer, Mitchell Singer, MR Neunuebel, MV Navarro, N Sudarsan, N Tschowri, NB Caberoy, PD Newell, PV Krasteva, PV Krasteva, R Hengge, R Paul, R Paul, R Tamayo, RP Ryan, RP Ryan, RP Ryan, S Abel, S Steiner, SS Wu, SS Wu, SS Wu, SZ Sultan, T Petters, T Schirmer, TA Ramelot, TM Gronewold, Tobias Petters, U Römling, V Jakovljevic, Volkhard Kaever, W Li, X Fang, Y Li, Y Qi, Z Yang, ZH Chen, ZM Yang   +87 more
core   +6 more sources

Polarity of c-di-GMP synthesis and degradation

microLife, 2023
AbstractThe bacterial cell pole has long been recognized as a defined compartment for enzymatic activities that are important or even vital for the cell. Polarity of diguanylate cyclases and phosphodiesterases, enzymes that synthesize and degrade the second messenger c-di-GMP, has now been demonstrated for several bacterial systems.
Vanessa Kreiling, Kai M Thormann
openaire   +2 more sources

Mutant structure of metabolic switch protein in complex with monomeric c-di-GMP reveals a potential mechanism of protein-mediated ligand dimerization

Scientific Reports, 2023
Bacterial second messengers c-di-GMP and (p)ppGpp have broad functional repertoires ranging from growth and cell cycle control to the regulation of biofilm formation and virulence.
Badri Nath Dubey, Viktoriya Shyp, Geoffrey Fucile, Holger Sondermann, Urs Jenal, Tilman Schirmer   +5 more
doaj   +1 more source

High levels of cyclic di-GMP in Klebsiella pneumoniae attenuate virulence in the lung [PDF]

, 2018
The bacterial second messenger bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) has been shown to influence the expression of virulence factors in certain pathogenic bacteria, but little is known about its activity in the increasingly antibiotic-resistant ...
Hunstad, David A, Rosen, David A, Twentyman, Joy   +2 more
core   +2 more sources

A Filter Binding Assay to Quantify the Association of Cyclic di-GMP to Proteins

Bio-Protocol, 2015
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many processes in bacteria including biofilm formation, motility, and virulence (Hengge, 2009). Analysis of c-di-GMP binding properties of bacterial proteins is an important step to
Disha Srivastava, Christopher Waters
doaj   +1 more source

Heterogeneity in Surface Sensing Suggests a Division of Labor in Pseudomonas aeruginosa Populations [PDF]

, 2019
The second messenger signaling molecule cyclic diguanylate monophosphate (c-di-GMP) drives the transition between planktonic and biofilm growth in many bacterial species.
Armbuster, Catherine R., de Anda, Jaime, Harwood, Caroline S., Hoffman, Lucas R., Jin, Fan, Lee, Calvin K., Murakami, Keiji, Parker-Gilham, Jessica, Parsek, Matthew R., Tseng, Boo Shan, Wong, Gerard CL, Xia, Aiguo, Zhao, Kun   +12 more
core   +2 more sources

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation [PDF]

, 2017
The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Cecéília M. Arraiano, Clémentine Dressaire, Lisete Galego, Ricardo N. Moreira, Susan Gottesman, Susana Barahona, Urs Jenal, Volkhard Kaever   +7 more
core   +5 more sources

Dissecting the molecular dance: c-di-GMP, cAMP-CRP, and VfmH collaboration in pectate lyase regulation for Dickeya dadantii—unveiling the soft rot pathogen’s strategy

Microbiology Spectrum, 2023
Dickeya dadantii is a Gram-negative bacterium that causes soft rot diseases in a variety of plants. This pathogen secretes pectate lyase (Pel) enzymes to degrade the plant cell wall, a process controlled by the bacterial second messenger cyclic ...
Biswarup Banerjee, Xiaochen Yuan, Ching-Hong Yang   +2 more
doaj   +1 more source