Results 31 to 40 of about 2,212 (248)

Nuclear expression of diacylglycerol kinases: possible involvement in DNA replication

European Journal of Histochemistry, 2009
The existence of intranuclear lipid-dependent signal transduction systems has been demonstrated by several independent groups. Remarkably, intranuclear lipid-dependent signal transduction pathways are regulated independently from their membrane/cytosolic
C Evangelisti, R Bortul, G Tabellini, V Papa, L Cocco, AM Martelli   +5 more
doaj   +1 more source

MITOCHONDRIAL REACTIVE OXYGEN SPECIES (ROS) AS SIGNALLING MOLECULES OF INTRACELLULAR PATHWAYS TRIGGERED BY THE CARDIAC RENIN-ANGIOTENSIN II-ALDOSTERONE SYSTEM (RAAS).

Frontiers in Physiology, 2013
Mitochondria represent major sources of basal reactive oxygen species (ROS) production of the cardiomyocyte. The role of ROS as signalling molecules that mediate different intracellular pathways has gained increasing interest among physiologists in the ...
Verónica Celeste De Giusti, Claudia Irma Caldiz, Irene Lucía Ennis, Néstor Gustavo Pérez, Horacio Eugenio Cingolani, Ernesto Alejandro Aiello   +5 more
doaj   +1 more source

Novel cyclic di-GMP effectors of the YajQ protein family control bacterial virulence [PDF]

, 2014
Bis-(3',5') cyclic di-guanylate (cyclic di-GMP) is a key bacterial second messenger that is implicated in the regulation of many critical processes that include motility, biofilm formation and virulence. Cyclic di-GMP influences diverse functions through
Caly, Delphine L., Joseph Ward (645977), Yvonne McCarthy (109070), Melanie Febrer (185470), Murdoch, Sarah L., Dow, J. Maxwell, Joseph Ward, Robert P. Ryan (108478), Ryan, Robert P., An, Shi Qi, An Shi-qi, Ryan Robert P., Shi-qi An, Robert P Ryan, J. Maxwell Dow (269095), J Maxwell Dow, McCarthy Yvonne, Caly Delphine L., Dow J. Maxwell, An, Shi-qi, Ward Joseph, Delphine L Caly, Yvonne McCarthy, McCarthy, Yvonne, Sarah L Murdoch, Melanie Febrer, Sarah L. Murdoch (645976), Ward, Joseph, Shi-qi An (5661025), Febrer Melanie, Febrer, Melanie, Delphine L. Caly (146386), Murdoch Sarah L.   +32 more
core   +1 more source

Molecular Imaging Studies of Second Messenger Pathways: Looking Deeper than the Membrane

, 2012
The most successful applications of molecular imaging by PET include studies of energy metabolism, dopamine synthesis, transporters, and membrane-bound receptors.
Paul Cumming, Vasdev, Neil, Neil Vasdev, Cumming, Paul   +3 more
core   +1 more source

Multiple Second-Messenger System Modulation of Voltage-Activated Calcium Currents in Teleost Retinal Horizontal Cells

, 1998
Pfeiffer-Linn, Cindy L. and Eric M. Lasater. Multiple second-messenger system modulation of voltage-activated calcium currents in teleost retinal horizontal cells. J. Neurophysiol. 80: 377–388, 1998.
Eric M. Lasater, Cindy L. Pfeiffer-Linn
core   +1 more source

Roles of Nicotinamide Adenine Dinucleotide (NAD+) in Biological Systems

Challenges, 2018
NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organism homeostasis. NAD+ is a coenzyme in redox reactions, a donor of adenosine diphosphate-ribose (ADPr) moieties in ADP-
Palmiro Poltronieri, Nataša Čerekovic
doaj   +1 more source

Emerging Concepts on the Role of ADP-Ribosylation

Challenges, 2020
NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Differential actions of second messenger systems in the corpus luteum [PDF]

Bioscientifica Proceedings, 2019
Our current working hypothesis for the intracellular mechanism of action for LH and PGF-2 alpha is shown in Fig. 8. Luteinizing hormone appears to act primarily on the small luteal cell through the cAMP/protein kinase A effector system and thereby stimulates secretion of progesterone. Activation of the protein kinase C effector pathway is inhibitory to
M C, Wiltbank, M G, Diskin, G D, Niswender   +2 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source