Subcellular second messenger networks drive distinct repellent-induced axon behaviors [PDF]
Nature Communications, 2023 Second messengers, including cAMP, cGMP and Ca2+ are often placed in an integrating position to combine the extracellular cues that orient growing axons in the developing brain.
Sarah Baudet +10 more
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C-di-AMP Is a Second Messenger in Corynebacterium glutamicum That Regulates Expression of a Cell Wall-Related Peptidase via a Riboswitch [PDF]
Microorganisms, 2023 Cyclic di-adenosine monophosphate (c-di-AMP) is a bacterial second messenger discovered in Bacillus subtilis and involved in potassium homeostasis, cell wall maintenance and/or DNA stress response.
Sebastian J. Reich +5 more
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Algorithm for biological second messenger analysis with dynamic regions of interest. [PDF]
PLoS ONE, 2023 Physiological function is regulated through cellular communication that is facilitated by multiple signaling molecules such as second messengers.
Jennifer M Knighten +8 more
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Allosteric regulation of glycogen breakdown by the second messenger cyclic di-GMP [PDF]
Nature Communications, 2022 c-di-GMP has emerged as the signal controlling development in antibiotic producing Streptomyces. Here the authors describe another developmental role of c-di-GMP, in energy metabolism, by activating the glycogen-debranchingenzyme, GlgX.
Maria A. Schumacher +9 more
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Aortic Valve Embryology, Mechanobiology, and Second Messenger Pathways: Implications for Clinical Practice [PDF]
Journal of Cardiovascular Development and DiseaseDuring the Renaissance, Leonardo Da Vinci was the first person to successfully detail the anatomy of the aortic root and its adjacent structures. Ever since, novel insights into morphology, function, and their interplay have accumulated, resulting in ...
Maximiliaan L. Notenboom +5 more
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Membrane-embedded CdaA is required for efficient synthesis of second messenger cyclic di-AMP [PDF]
Communications BiologyCyclic di-adenylate monophosphate (cyclic di-AMP) is an important second messenger in microorganisms. Cyclic di-AMP regulates bacterial cell volume and turgor via control of potassium and compatible solute transport but is also involved in many other ...
Alexander J. Foster +6 more
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S‐adenosyl methionine‐AMP opens another skylight of CRISPR system: discovering novel second messenger for bacterial antiviral immunity [PDF]
MedCommYongye Huang, Sihui Zhang, Min Wu
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Cold Spring Harbor Perspectives in Biology, 2016 Second messengers are small molecules and ions that relay signals received by cell-surface receptors to effector proteins. They include a wide variety of chemical species and have diverse properties that allow them to signal within membranes (e.g., hydrophobic molecules such as lipids and lipid derivatives), within the cytosol (e.g., polar molecules ...
Newton, Alexandra C. +2 more
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Regulation of α‐cell glucagon secretion: The role of second messengers
Chronic Diseases and Translational Medicine, 2022 Glucagon is a potent glucose‐elevating hormone that is secreted by pancreatic α‐cells. While well‐controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is increasingly apparent ...
Samuel Acreman, Quan Zhang
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Cancer—A Major Cardiac Comorbidity With Implications on Cardiovascular Metabolism
Frontiers in Physiology, 2021 Cardiovascular diseases have multifactorial causes. Classical cardiovascular risk factors, such as arterial hypertension, smoking, hyperlipidemia, and diabetes associate with the development of vascular stenoses and coronary heart disease.
Daniel Finke +11 more
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