Results 1 to 10 of about 69 (62)
MicrobiologyOpen, 2021 Streptococcus mitis is a commensal bacterial species of the oral cavity, with the potential for opportunistic pathogenesis. For successful colonization, S.
Gro Herredsvela Rørvik +3 more
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Mycobacterium tuberculosis Rv3586 (DacA) Is a Diadenylate Cyclase That Converts ATP or ADP into c-di-AMP [PDF]
PLoS ONE, 2012 Cyclic diguanosine monophosphate (c-di-GMP) and cyclic diadenosine monophosphate (c-di-AMP) are recently identified signaling molecules. c-di-GMP has been shown to play important roles in bacterial pathogenesis, whereas information about c-di-AMP remains
Yinlan Bai, Guangchun Bai
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Bio-protocol, 2021 All living cells use cyclic nucleotides as second messengers for signal sensing and transduction. Cyclic di-3′,5′-adenosine monophosphate (c-di-AMP) is primarily involved in the control of bacterial and euryarcheal osmoadaptation and is produced by ...
Natalia Tschowri, Gregor Witte
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MicrobiologyOpen, 2019 The role of cyclic nucleotides as second messengers for intracellular signal transduction has been well described in bacteria. One recently discovered bacterial second messenger is cyclic di‐adenylate monophosphate (c‐di‐AMP), which has been demonstrated
Frank Braun +6 more
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Functional analysis of the sporulation-specific diadenylate cyclase CdaS in Bacillus thuringiensis
Frontiers in Microbiology, 2015 Cyclic di-AMP (c-di-AMP) is a recently discovered bacterial secondary messenger molecule, which is associated with various physiological functions. In Bacillus, the intracellular level and turnover of c-di-AMP is mainly regulated by three diadenylate ...
Jin He, Yuqun Xie, Xun Wang
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Altered abundance in cancer patients gut of diadenylate cyclase-encoding bacteria
Scientific Reportsc-di-AMP is a bacterial second messenger recognized by host immune sensors such as the STING pathway, linking gut microbiota activity to tumor immunity.
Maddalena Rossi +2 more
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Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase
MSystemsIn many gram-positive bacteria, the diadenylate cyclase DacA synthesizes the essential second messenger c-di-AMP. While regulators like GlmM and CdaR are known, the broader DacA interactome and its functional relevance remain poorly defined.
Rong Mu
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IPA-3: An Inhibitor of Diadenylate Cyclase of Streptococcus suis with Potent Antimicrobial Activity
Antibiotics, 2022 Antimicrobial resistance (AMR) poses a huge threat to public health. The development of novel antibiotics is an effective strategy to tackle AMR. Cyclic diadenylate monophosphate (c-di-AMP) has recently been identified as an essential signal molecule for
Haotian Li +10 more
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Two-step synthesis and hydrolysis of cyclic di-AMP in Mycobacterium tuberculosis. [PDF]
PLoS ONE, 2014 Cyclic di-AMP is a recently discovered signaling molecule which regulates various aspects of bacterial physiology and virulence. Here we report the characterization of c-di-AMP synthesizing and hydrolyzing proteins from Mycobacterium tuberculosis ...
Kasi Manikandan +5 more
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High-throughput interaction screens illuminate the role of c-di-AMP in cyanobacterial nighttime survival. [PDF]
PLoS Genetics, 2018 The broadly conserved signaling nucleotide cyclic di-adenosine monophosphate (c-di-AMP) is essential for viability in most bacteria where it has been studied. However, characterization of the cellular functions and metabolism of c-di-AMP has largely been
Benjamin E Rubin +11 more
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