Results 11 to 20 of about 34,752 (95)

The Leptospira interrogans CdaA protein is a functional diadenylate cyclase

Infection and Immunity
Leptospirosis is a zoonotic disease that affects humans, companion animals, livestock, and wildlife. There are over 60 species that are established pathogens.
Edward J. A. Schuler, Dhara T. Patel, Aidan D. Moylan, Daniel P. Miller, Richard T. Marconi   +4 more
doaj   +2 more sources

Bioinformatics Analysis of Diadenylate Cyclase Regulation on Cyclic Diadenosine Monophosphate Biosynthesis in Exopolysaccharide Production by Leuconostoc mesenteroides DRP105

Fermentation
Lactic acid bacteria exopolysaccharides (EPS) have a variety of excellent biological functions and are widely used in the food and pharmaceutical industries.
Wenna Yu, Liansheng Yu, Tengxin Li, Ziwen Wang, Renpeng Du, Wenxiang Ping   +5 more
doaj   +2 more sources

Mutation in the C-di-AMP cyclase dacA affects fitness and resistance of methicillin resistant Staphylococcus aureus. [PDF]

PLoS ONE, 2013
Faster growing and more virulent strains of methicillin resistant Staphylococcus aureus (MRSA) are increasingly displacing highly resistant MRSA. Elevated fitness in these MRSA is often accompanied by decreased and heterogeneous levels of methicillin ...
Vanina Dengler, Nadine McCallum, Patrick Kiefer, Philipp Christen, Andrea Patrignani, Julia A Vorholt, Brigitte Berger-Bächi, Maria M Senn   +7 more
doaj   +3 more sources

Treponema denticola synthesizes c-di-AMP and encodes the CdaA-type diadenylate cyclase CdaA [PDF]

, 2023
Periodontitis is a form of oral disease characterized by dysbiosis of the oral microbiome, leading to inflammation, bone resorption, and in severe cases, entire tooth loss, affecting 42% of adults in the US.
O\u27Brien, Claire R
core   +1 more source

Study of NIT domain‐containing chemoreceptors from two global phytopathogens and identification of NIT domains in eukaryotes

Molecular Microbiology, Volume 119, Issue 6, Page 739-751, June 2023., 2023
NIT sensor domains were found in 19 eukaryotic and 30 bacterial phyla and formed part of 7 receptor families that generate a variety of different responses, such as chemotaxis, transcriptional regulation or homeostasis of second messenger levels.
Elizabet Monteagudo‐Cascales, Álvaro Ortega, Félix Velando, Bertrand Morel, Miguel A. Matilla, Tino Krell   +5 more
wiley   +1 more source

Two cyanobacterial response regulators with diguanylate cyclase activity, Rre2 and Rre8, participate in biofilm formation

Molecular Microbiology, Volume 119, Issue 5, Page 599-611, May 2023., 2023
The model cyanobacterium, Synechocystis sp. PCC 6803, switches between a planktonic and a biofilm lifestyle in response to fluctuating environmental conditions. The two‐component regulatory systems, Hik12‐Rre2 and Hik14‐Rre8, function in biofilm formation during high salt stress.
Ayumu Kobayashi, Masamune Nakamura, Masaru Tsujii, Kohei Makino, Tatsuya Nagayama, Kensuke Nakamura, Kei Nanatani, Kera Kota, Yuki Furuuchi, Shunsuke Kayamori, Tadaomi Furuta, Iwane Suzuki, Yoshihiro Hayakawa, Ellen Tanudjaja, Yasuhiro Ishimaru, Nobuyuki Uozumi   +15 more
wiley   +1 more source

Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway

Research, 2023
The stimulator of interferon genes (STING) protein is an important and promising innate immune target for tumor therapy. However, the instability of the agonists of STING and their tendency to cause systemic immune activation is a hurdle.
Yu Jiang, Xiyuan Li, Fenghui Qian, Bingbing Sun, Xiyuan Wang, Yan Zhang, Deqiang Zhang, Meiyu Geng, Zuoquan Xie, Sheng Yang   +9 more
doaj   +1 more source

Is biofilm formation intrinsic to the origin of life?

Environmental Microbiology, Volume 25, Issue 1, Page 26-39, January 2023., 2023
Abstract Biofilms are multicellular, often surface‐associated, communities of autonomous cells. Their formation is the natural mode of growth of up to 80% of microorganisms living on this planet. Biofilms refractory towards antimicrobial agents and the actions of the immune system due to their tolerance against multiple environmental stresses.
Ute Römling
wiley   +1 more source

Adaptation of Listeria monocytogenes to perturbation of c‐di‐AMP metabolism underpins its role in osmoadaptation and identifies a fosfomycin uptake system

Environmental Microbiology, Volume 24, Issue 9, Page 4466-4488, September 2022., 2022
Summary The human pathogen Listeria monocytogenes synthesizes and degrades c‐di‐AMP using the diadenylate cyclase CdaA and the phosphodiesterases PdeA and PgpH respectively. c‐di‐AMP is essential because it prevents the uncontrolled uptake of osmolytes.
Mengyi Wang, Sabrina Wamp, Johannes Gibhardt, Gudrun Holland, Inge Schwedt, Kai‐Uwe Schmidtke, Katrin Scheibner, Sven Halbedel, Fabian M. Commichau   +8 more
wiley   +1 more source

CRISPR-mediated rapid arming of poxvirus vectors enables facile generation of the novel immunotherapeutic STINGPOX

Frontiers in Immunology, 2023
Poxvirus vectors represent versatile modalities for engineering novel vaccines and cancer immunotherapies. In addition to their oncolytic capacity and immunogenic influence, they can be readily engineered to express multiple large transgenes.
Jack T. Whelan, Jack T. Whelan, Ragunath Singaravelu, Ragunath Singaravelu, Ragunath Singaravelu, Fuan Wang, Fuan Wang, Adrian Pelin, Adrian Pelin, Levi A. Tamming, Levi A. Tamming, Giuseppe Pugliese, Nikolas T. Martin, Nikolas T. Martin, Mathieu J. F. Crupi, Mathieu J. F. Crupi, Julia Petryk, Bradley Austin, Xiaohong He, Ricardo Marius, Ricardo Marius, Jessie Duong, Jessie Duong, Carter Jones, Emily E. F. Fekete, Emily E. F. Fekete, Nouf Alluqmani, Nouf Alluqmani, Andrew Chen, Stephen Boulton, Stephen Boulton, Michael S. Huh, Matt Y. Tang, Zaid Taha, Zaid Taha, Elena Scut, Elena Scut, Jean-Simon Diallo, Jean-Simon Diallo, Taha Azad, Taha Azad, Brian D. Lichty, Brian D. Lichty, Carolina S. Ilkow, Carolina S. Ilkow, John C. Bell, John C. Bell   +46 more
doaj   +1 more source