Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis [PDF]
mBio, 2021 The bacterial second messenger cyclic di-AMP (c-di-AMP) is a global regulator of potassium homeostasis and compatible solute uptake in many Gram-positive bacteria, making it essential for osmoregulation.
Huong Thi Pham +10 more
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The second messenger signaling molecule cyclic di-AMP drives developmental cycle progression in Chlamydia trachomatis [PDF]
eLifeThe obligate intracellular bacterium Chlamydia alternates between two functional forms during its developmental cycle: elementary body (EB) and reticulate body (RB).
Junghoon Lee, Scot P Ouellette
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Atypical cyclic di-AMP signaling is essential for Porphyromonas gingivalis growth and regulation of cell envelope homeostasis and virulence [PDF]
npj Biofilms and Microbiomes, 2022 Microbial pathogens employ signaling systems through cyclic (di-) nucleotide monophosphates serving as second messengers to increase fitness during pathogenesis.
M. Fata Moradali +5 more
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Membrane-embedded CdaA is required for efficient synthesis of second messenger cyclic di-AMP [PDF]
Communications BiologyCyclic di-adenylate monophosphate (cyclic di-AMP) is an important second messenger in microorganisms. Cyclic di-AMP regulates bacterial cell volume and turgor via control of potassium and compatible solute transport but is also involved in many other ...
Alexander J. Foster +6 more
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Sustained Control of Pyruvate Carboxylase by the Essential Second Messenger Cyclic di-AMP in Bacillus subtilis [PDF]
mBio, 2022 In Bacillus subtilis and other Gram-positive bacteria, cyclic di-AMP is an essential second messenger that signals potassium availability by binding to a variety of proteins.
Larissa Krüger +8 more
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Cyclic di-AMP signaling and regulation in Staphylococcus aureus [PDF]
mSphereCyclic di-AMP (c-di-AMP) is an essential bacterial second messenger that coordinates multiple cellular processes and is closely linked to central physiology in many bacteria. In Staphylococcus aureus, both depletion and excessive accumulation of c-di-AMP
Seonmin Lee +3 more
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Cyclic di-AMP traps proton-coupled K+ transporters of the KUP family in an inward-occluded conformation [PDF]
Nature Communications, 2023 Cyclic di-AMP is the only known essential second messenger in bacteria and archaea, regulating different proteins indispensable for numerous physiological processes.
Michael F. Fuss +8 more
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Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae [PDF]
Frontiers in Microbiology, 2017 Bacteria often use cyclic dinucleotides as second messengers for signal transduction. While the classical molecule c-di-GMP is involved in lifestyle selection, the functions of the more recently discovered signaling nucleotide cyclic di-AMP are less ...
Cedric Blötz +5 more
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Cyclic nucleotides in archaea: Cyclic di‐AMP in the archaeon Haloferax volcanii and its putative role [PDF]
MicrobiologyOpen, 2019 The role of cyclic nucleotides as second messengers for intracellular signal transduction has been well described in bacteria. One recently discovered bacterial second messenger is cyclic di‐adenylate monophosphate (c‐di‐AMP), which has been demonstrated
Frank Braun +6 more
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Homeostasis of Second Messenger Cyclic-di-AMP Is Critical for Cyanobacterial Fitness and Acclimation to Abiotic Stress [PDF]
Frontiers in Microbiology, 2018 Second messengers are intracellular molecules regulated by external stimuli known as first messengers that are used for rapid organismal responses to dynamic environmental changes.
Marco Agostoni +12 more
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