Cyclic di-AMP regulation of osmotic homeostasis is essential in Group B Streptococcus. [PDF]
PLoS Genetics, 2018 Cyclic nucleotides are universally used as secondary messengers to control cellular physiology. Among these signalling molecules, cyclic di-adenosine monophosphate (c-di-AMP) is a specific bacterial second messenger recognized by host cells during ...
Laura Devaux +7 more
doaj +2 more sources
Enzyme Characterization of Pro-virulent SntA, a Cell Wall-Anchored Protein of Streptococcus suis, With Phosphodiesterase Activity on cyclic-di-AMP at a Level Suited to Limit the Innate Immune System [PDF]
Frontiers in Microbiology, 2022 Streptococcus suis and Streptococcus agalactiae evade the innate immune system of the infected host by mechanisms mediated by cell wall-anchored proteins: SntA and CdnP, respectively.
Alicia Cabezas +6 more
doaj +2 more sources
Unique Roles for Streptococcus pneumoniae Phosphodiesterase 2 in Cyclic di-AMP Catabolism and Macrophage Responses [PDF]
Frontiers in Immunology, 2020 Cyclic di-AMP (c-di-AMP) is an important signaling molecule for pneumococci, and as a uniquely prokaryotic product it can be recognized by mammalian cells as a danger signal that triggers innate immunity.
Alicia K. Wooten +18 more
doaj +2 more sources
Cyclic di-AMP Acts as an Extracellular Signal That Impacts
mBio, 2018 There is a growing appreciation for the impact that bacteria have on higher organisms. Plant roots often harbor beneficial microbes, such as the Gram-positive rhizobacterium Bacillus subtilis, that influence their growth and susceptibility to disease ...
Loni Townsley +4 more
doaj +2 more sources
Enhanced uptake of potassium or glycine betaine or export of cyclic-di-AMP restores osmoresistance in a high cyclic-di-AMP Lactococcus lactis mutant. [PDF]
PLoS Genetics, 2018 The broadly conserved bacterial signalling molecule cyclic-di-adenosine monophosphate (c-di-AMP) controls osmoresistance via its regulation of potassium (K+) and compatible solute uptake.
Huong Thi Pham +13 more
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Cyclic-di-AMP signalling in lactic acid bacteria. [PDF]
FEMS Microbiol Rev, 2023 Cyclic dimeric adenosine monophosphate (cyclic-di-AMP) is a nucleotide second messenger present in Gram-positive bacteria, Gram-negative bacteria and some Archaea.
Turner MS +4 more
europepmc +2 more sources
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J. +2 more
core +4 more sources
Nucleotides as Bacterial Second Messengers
Molecules, 2023 In addition to comprising monomers of nucleic acids, nucleotides have signaling functions and act as second messengers in both prokaryotic and eukaryotic cells. The most common example is cyclic AMP (cAMP).
Mario E. Cancino-Diaz +3 more
doaj +1 more source
The mucosal adjuvant cyclic di-AMP exerts immune stimulatory effects on dendritic cells and macrophages. [PDF]
PLoS ONE, 2014 The cyclic di-nucleotide bis-(3',5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a candidate mucosal adjuvant with proven efficacy in preclinical models.
Ivana Škrnjug +5 more
doaj +1 more source
Nature Communications, 2021 In several bacteria, cyclic di-AMP mediates potassium (K+) and osmotic homeostasis. Here, the authors show that DarB, a Bacillus subtilis protein previously reported to bind cyclic di-AMP, interacts with the (p)ppGpp synthetase/hydrolase Rel in a K ...
Larissa Krüger +8 more
doaj +1 more source