Results 41 to 50 of about 14,640,780 (243)

The c‐di‐AMP signaling system influences stress tolerance and biofilm formation of Streptococcus mitis

MicrobiologyOpen, 2021
Streptococcus mitis is a commensal bacterial species of the oral cavity, with the potential for opportunistic pathogenesis. For successful colonization, S.
Gro Herredsvela Rørvik, Ali‐Oddin Naemi, Per Kristian Thorén Edvardsen, Roger Simm   +3 more
doaj   +1 more source

The role of bacterial cyclic di-adenosine monophosphate in the host immune response

Frontiers in Microbiology, 2022
Cyclic di-adenosine monophosphate (c-di-AMP) is a second messenger which is widely used in signal transduction in bacteria and archaea. c-di-AMP plays an important role in the regulation of bacterial physiological activities, such as the cell cycle, cell
Xingqun Cheng, Jia Ning, Xin Xu, Xuedong Zhou   +3 more
doaj   +1 more source

3',5'-Cyclic Adenosine Monophosphate- and Ca2+-Calmodulin-Dependent Endogenous Protein Phosphorylation Activity in Membranes of the Bovine Chromaffin Secretory Vesicles: Identification of Two Phosphorylated Components as Tyrosine Hydroxylase and Protein Kinase Regulatory Subunit Type II [PDF]

, 1983
: Membranes of the secretory vesicles from bovine adrenal medulla were investigated for the presence of the endogenous protein phosphorylation activity. Seven phosphoprotein bands in the molecular weight range of 250,000 to 30,000 were observed by means ...
Weber, W., Treiman, M., Gratzl, Manfred
core   +1 more source

STING-Dependent Recognition of Cyclic di-AMP Mediates Type I Interferon Responses during Chlamydia trachomatis Infection

mBio, 2013
STING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent type I ...
Jeffrey R. Barker, Benjamin J. Koestler, Victoria K. Carpenter, Dara L. Burdette, Christopher M. Waters, Russell E. Vance, Raphael H. Valdivia   +6 more
doaj   +1 more source

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP

Journal of Oral Microbiology, 2022
Background Constant exposure of human gingival fibroblasts (HGFs) to oral pathogens trigger selective immune responses. Recently, the activation of immune response to cyclic dinucleotides (CDNs) via STING has come to the forefront.
Kenneth I. Onyedibe, Samira Elmanfi, Uma K. Aryal, Eija Könönen, Ulvi Kahraman Gürsoy, Herman O. Sintim   +5 more
doaj   +1 more source

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response. [PDF]

, 2012
The induction of type I interferons by the bacterial secondary messengers cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3.
Ouyang, Songying, Zhiqiang Zhang, Iyer, Shankar S, Schenk, Mirjam, Liu, Zhi-Jie, Zhong, Wenwan, Parvatiyar, Kislay, Mirjam Schenk, Yong-jun Liu, Zaver, Shivam A, Kislay Parvatiyar, Liu, Yong-jun, Genhong Cheng, Jiang, Yan, Zeng, Shang, Modlin, Robert L, Songying Ouyang, Yan Jiang, Wenwan Zhong, Cheng, Genhong, Teles, Rosane M, Robert L Modlin, Zhi-Jie Liu, Shivam A Zaver, Shang Zeng, Rosane M Teles, Zhang, Zhiqiang, Shankar S Iyer   +27 more
core   +2 more sources

Biological and Biochemical Roles of Two Distinct Cyclic Dimeric Adenosine 3′,5′-Monophosphate- Associated Phosphodiesterases in Streptococcus mutans

Frontiers in Microbiology, 2018
Cyclic dimeric adenosine 3′,5′-monophosphate (c-di-AMP), a recently identified secondary messenger in bacteria, plays a role in several bacterial processes, including biofilm formation. It is enzymatically produced by diadenylate cyclase and cleaved by c-
Hiroyasu Konno, Hiroyasu Konno, Yasuo Yoshida, Keiji Nagano, Jun Takebe, Yoshiaki Hasegawa   +5 more
doaj   +1 more source

Intracellular Concentrations of Borrelia burgdorferi Cyclic Di-AMP Are Not Changed by Altered Expression of the CdaA Synthase. [PDF]

PLoS ONE, 2015
The second messenger nucleotide cyclic diadenylate monophosphate (c-di-AMP) has been identified in several species of Gram positive bacteria and Chlamydia trachomatis. This molecule has been associated with bacterial cell division, cell wall biosynthesis
Christina R Savage, William K Arnold, Alexandra Gjevre-Nail, Benjamin J Koestler, Eric L Bruger, Jeffrey R Barker, Christopher M Waters, Brian Stevenson   +7 more
doaj   +1 more source

C-di-AMP levels modulate Staphylococcus aureus cell wall thickness, response to oxidative stress, and antibiotic resistance and tolerance

Microbiology Spectrum, 2023
Beta-lactam antibiotics are widely used to treat infections caused by the important human pathogen Staphylococcus aureus. Resistance to beta-lactams, as found in methicillin-resistant S. aureus, renders effective treatment difficult. The second messenger
Vanina Dengler Haunreiter, Andrea Tarnutzer, Julian Bär, Manuela von Matt, Sanne Hertegonne, Federica Andreoni, Clément Vulin, Lisa Künzi, Carmen Menzi, Patrick Kiefer, Philipp Christen, Julia A. Vorholt, Annelies S. Zinkernagel   +12 more
doaj   +1 more source

The regulation of alginate biosynthesis via cyclic di-GMP signaling

, 2020
Bacterial alginates are anionic exopolysaccharides, which are produced by Pseudomonas and Azotobacter species. Bacterial cells embedded in extracellular polymeric substances such as alginates have a survival advantage as they are protected against ...
Rehm, BHA, Moradali, MF
core   +1 more source